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Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test
Date:5/1/2008

Interleukin 1B genetic patterns predict life-long tendency to inflammation

and related cardiovascular event risk profile

WALTHAM, Mass., May 1 /PRNewswire-FirstCall/ -- Interleukin Genetics, Inc. (Amex: ILI), today announced publication of the results of clinical studies that support the company's Heart Health Genetic Test to assess cardiovascular risk. The article, titled, "IL1B Gene Promoter Haplotype Pairs Predict Clinical Levels of Interleukin-1beta and C-reactive Protein," was published in the journal Human Genetics (123:387-398; May 2008) and further confirms prior studies associating variations in the Interleukin 1B (IL1B) gene with the inflammatory response.

To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/ilgenetics/32863/

Sir Gordon W. Duff, M.D., Ph.D., one of the pioneers in the genetics of inflammatory diseases, was the senior author of the paper. Dr. Duff, former Director of the Division of Genomic Medicine, University of Sheffield, UK, commented, "It is now well recognized that inflammation is an underlying factor in many diseases including cardiovascular disease. Interleukin-1beta (IL-1beta) is a major regulator of inflammation. This paper from a collaborative team of international researchers, demonstrates that people with specific variation patterns in the IL1B gene had higher levels of IL-1beta and C-reactive protein (CRP). Studies from our group and others have found that these same IL1B gene variations were associated with an increased risk for cardiovascular disease and an increased risk for myocardial infarction at a younger age, that is, an early first heart attack."

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SOURCE Interleukin Genetics, Inc.
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