Navigation Links
Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia
Date:12/8/2008

mmended starting dose and increased as tolerated. Doses greater than 600 mg are not recommended in patients with mild renal impairment (CrCL = 40-59 mL/min). For patients with moderate renal impairment doses greater than 400 mg are not recommended. Gleevec should be used with caution in patients with severe renal impairment.

Patients should be weighed and monitored regularly for signs and symptoms of edema, which can be serious or life-threatening. There have also been reports, including fatalities, of cardiac tamponade, cerebral edema, acute respiratory failure, and GI perforation.

Bullous dermatologic reactions (e.g., erythema multiforme and Stevens-Johnson syndrome) have also been reported. In some cases, the reaction recurred upon re-challenge. Several post marketing reports describe patients able to tolerate the reintroduction of Gleevec at a lower dose with or without concomitant corticosteroids or antihistamines following resolution or improvement of the bullous reaction.

Consider potential toxicities-specifically liver, kidney, and cardiac toxicity, and immunosuppression from long-term use.

Gleevec is metabolized by the CYP3A4 isoenzyme and is an inhibitor of CYP3A4, CYP2D6, and CYP2C9. Dosage of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, warfarin, erythromycin, and phenytoin. (Please see full Prescribing Information for other potential drug interactions.)

For daily dosing of 800 mg and above, dosing should be accomplished using the 400 mg tablet to reduce exposure to iron.

Common side effects of Gleevec tablets

The majority of adult Ph+ CML patients who re
'/>"/>

SOURCE Novartis
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
3. Video: The Arizona Heart Institute Announces the Largest Worldwide Experience with Endoluminal Grafting to Treat Thoracic Aortic Aneurysms and Related Pathologies
4. Video: Actress and New Mom Keri Russell Joins PKIDs to Launch Silence the Sounds of Pertussis Campaign
5. Video: Quest Diagnostics Health Trends(TM) Report Shows Significant Gap in Care for Patients With Chronic Kidney Disease
6. Video: New Results From One of the Worlds Largest Breast Cancer Trials Herald Hope for Thousands of Women
7. VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy
8. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
9. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
10. Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
11. Video: Sanford Healths Journey to Cure Type 1 Diabetes Receives Major Boost
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... , Sept. 18, 2014   3D Systems   ... the Simbionix RobotiX Mentor™ , a new robotic surgery ... the first time at the ERUS exhibition in ... (booth #7). Robotic-assisted minimally invasive surgery represents a ... means the needs for training for robotic surgery has increased, ...
(Date:9/18/2014)... After 6 months of careful research ... - the new programme for the next Cool Chain & ... global Cool Chain series, has just been released! ... As the lines between supply chain, logistics, QA and purchasing ... is broad and yet specific, focused and yet accessible, inclusive ...
(Date:9/18/2014)... new expert panel report, Improving Medicines for Children ... by the Council of Canadian Academies, addresses the importance ... year about half of Canada,s ... Much of this prescribing is done off-label (i.e. the ... risks. Children have historically been excluded in ...
Breaking Medicine Technology:3D Systems Introduces New Simbionix Robotics Training Platform 23D Systems Introduces New Simbionix Robotics Training Platform 3Europe's Biggest and Longest-Running Gathering of Life Sciences Logistics, Supply Chain & QA Professionals 2Studying medicines in children is always possible and is in their best interest, finds Expert Panel 2Studying medicines in children is always possible and is in their best interest, finds Expert Panel 3
... Sept. 10 National Jewish Health and,Roche ... to pursue,opportunities in the growing field of ... expertise in clinical testing,and care for patients ... technology to bring new diagnostic solutions to,the ...
... September 10 Circassia Ltd, a,specialty biopharmaceutical ... announced positive results from a phase II ... the field of cat allergy.,The trial showed ... to the allergen that causes most cat ...
Cached Medicine Technology:National Jewish Health and Roche Diagnostics Corporation Reach Agreement to Pursue Environmental Molecular Diagnostics Opportunities 2Circassia Achieves Successful Phase II Clinical Results With Toleromune(R) Anti-Allergy Technology 2Circassia Achieves Successful Phase II Clinical Results With Toleromune(R) Anti-Allergy Technology 3
(Date:9/18/2014)... Park City, Utah (PRWEB) September 19, 2014 ... Solution, published new information on why to switch employees ... Benefits, though many employees may be more familiar with ... individual health insurance that makes employees happier. , ... employees are happier with individual health insurance rather than ...
(Date:9/18/2014)... Mary Ann Thompson and Mathieu Nikel decided it was time to ... their son, Isaac, said there was only one choice for them ... 2001 when Thompson was an undergraduate student and needed a French ... time, was French and so she asked him. , ... when she was 7 years old. Nikel is originally from ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Active Aging ... and older as fully participating members of society and ... To celebrate, The Stafford – a boutique retirement community ... – will host two screenings of Cyber-Seniors - a ... for our residents to watch this great film,” says ...
(Date:9/18/2014)... world have issued a plea to researchers, academics, drug ... research and clinical trials for advanced breast cancer, a ... there are many unanswered questions. , In the latest ... cancer, published simultaneously in the leading cancer journals ... [1] today (Friday), the experts say that further research ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Memorial ... made history this week by performing the first ever, ... UNOS (United Network for Organ Sharing) approval to launch ... one of only two programs in South Florida. ... Dr. Enrique Gongora, Medical Director of the ...
Breaking Medicine News(10 mins):Health News:Zane Benefits Publishes New Information on Why Employees Are Happier with Individual Health Insurance 2Health News:For The First Time in Over a Decade Mercy College Alumni Marry at College 2Health News:In Support of Active Aging Week, a Lake Oswego Retirement Community Will Get a Sneak Peek at an Inter-Generational Documentary – Cyber-Seniors 2Health News:Experts issue plea for better research and education for advanced breast cancer 2Health News:Experts issue plea for better research and education for advanced breast cancer 3Health News:Experts issue plea for better research and education for advanced breast cancer 4Health News:Experts issue plea for better research and education for advanced breast cancer 5Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 2Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 3Health News:Memorial Cardiac & Vascular Institute Performs First Adult Heart Transplant in Broward County 4
... Reporter , MONDAY, Dec. 5 (HealthDay News) -- Eating ... salmon, may significantly lower a young woman,s risk of ... that women of childbearing age who never ate fish had ... often, and a 90 percent higher risk than women who ...
... has seen a dramatic increase in the presence of ... the stigmatized stereotype of gays into a new, socially ... marketing strategy affects the way gays understand themselves and ... explains Wan-Hsiu Sunny Tsai, assistant professor of advertising at ...
... By Jenifer Goodwin HealthDay Reporter , MONDAY, ... epilepsy drug valproate have a nearly three times higher ... finds. Researchers in Denmark used national birth data ... between 1996 and 2006 to 428,000 women. Using a ...
... , MONDAY, Dec. 5 (HealthDay News) -- A ... in the teenage brain. The research found that teens who,ve ... contains brain cells -- in some areas of the brain ... involved in the study had a history of abuse or neglect. ...
... Ky. -- University of Kentucky researchers recently received a ... in Appalachia. The grant gives the team $225,000 ... additional years that could total $675,000. It is funded ... the UK-based Rural Cancer Prevention Center. Published studies ...
... Respirology reveals that dust storms have an adverse ... known as chronic obstructive pulmonary disease (COPD). Dust storms ... dust that travels long distances from North China. The concentrations ... 10 micrometerscan reach very high levels. Researchers led by ...
Cached Medicine News:Health News:Fish May Cut Threat of Heart Disease in Young Women 2Health News:Fish May Cut Threat of Heart Disease in Young Women 3Health News:How advertising shapes the image of gayness in America 2Health News:Fetal Exposure to Epilepsy Drug Might Raise Autism Risk: Study 2Health News:Fetal Exposure to Epilepsy Drug Might Raise Autism Risk: Study 3Health News:Abuse in Childhood May Alter Teen Brain 2Health News:University of Kentucky researchers awarded CDC grant to study cancer survival in Appalachia 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: