Navigation Links
Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
Date:7/30/2008

mployed (CR, resveratrol, or nutriceutical matrix), the limited calorie diet affected about 187 genes (7%), resveratrol about 224 genes (8%), while the nutriceutical matrix influenced 1711 genes (61%), over a 9-fold difference.

Recent studies that have captured the public's attention have focused on molecules that can slow aging and have been narrowly focused on the sirtuin family of genes and their activation by resveratrol, known as a red wine molecule. Recently researchers have reported that entire gene networks rather than single genes are involved in metabolic disorders, such as elevated blood sugar and cancer. Researchers report that gene array testing can detect genes affected by an unhealthy diet before there is change shown in the blood sample. [Nature March 16, 2008]

The nutriceutical matrix of natural molecules (Longevinex(R)) exhibited a much broader impact upon gene expression and more strikingly affected key genes, like Pdk4 and Pgc1 alpha, involved in mitochondrial energy metabolism.

Only the nutriceutical matrix, and not resveratrol or a long-term calorie restricted diet, upregulated the Foxo1 gene which enters the cell nucleus and promotes the expression of key longevity genes.

These effects were accomplished with a relatively low human equivalent dose of resveratrol. At about 1/15th the dose employed in a prior widely acclaimed mouse study (Nature Magazine Nov. 1, 2006) the nutriceutical matrix was able to exert more demonstrable genomic effects.

Prior animal studies employed the human equivalent of 1565, 360 and 343 milligrams of resveratrol to produce longevity effects. The nutriceutical matrix exerted 9-fold greater effect over the mouse genome at the equivalent daily human dose of resveratrol of 100 milligrams per day. According to this study, if data from mice is applicable to humans, some widely promoted mega-dose resveratrol pills, providing 500 to 1000 milligrams of resveratrol, would not exert as broad an
'/>"/>

SOURCE Longevinex(R)
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Video: Sanford Healths Journey to Cure Type 1 Diabetes Receives Major Boost
2. Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
3. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
4. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
5. VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy
6. Video: New Results From One of the Worlds Largest Breast Cancer Trials Herald Hope for Thousands of Women
7. Video: Quest Diagnostics Health Trends(TM) Report Shows Significant Gap in Care for Patients With Chronic Kidney Disease
8. Video: Actress and New Mom Keri Russell Joins PKIDs to Launch Silence the Sounds of Pertussis Campaign
9. Video: The Arizona Heart Institute Announces the Largest Worldwide Experience with Endoluminal Grafting to Treat Thoracic Aortic Aneurysms and Related Pathologies
10. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
11. Video: New Research Discovers Independent Brain Networks Control Human Walking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 30, 2014   NxStage® Kidney Care, Inc ., a ... is proud to host the grand opening ceremony of its ... W. 16 th Street on November 20, 2014 from ... trained medical staff who are committed to providing patients with ... benefits made possible through more flexible dialysis treatment options.   ...
(Date:10/30/2014)... 2014   ViaDerma, Inc. (OTCQB: VDRM), ... products to market, has recently released a revolutionary ... a topical liquid tetracycline-based antibiotic that uses a ... oral medication active ingredients into topical drugs. The ... antibiotic to help prevent skin infection in minor ...
(Date:10/30/2014)... Oct. 30, 2014 China Biologic Products, Inc. ... fully integrated plasma-based biopharmaceutical company in China ... release third quarter 2014 financial results on Wednesday, November ... The Company,s management will hold a conference call at ... which is 8:30 p.m., Beijing Time on November 6, ...
Breaking Medicine Technology:Grand Opening of NxStage Kidney Care Oak Brook IL Center 2Grand Opening of NxStage Kidney Care Oak Brook IL Center 3ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3China Biologic to Report Third Quarter 2014 Financial Results 2
... Reportlinker.com announces that a new market research ... European Markets for Dental Bone Graft Substitutes, ... http://www.reportlinker.com/p0339837/European-Markets-for-Dental-Bone-Graft-Substitutes-Dental-Membranes-and-Tissue-Engineering-2011.html In ... graft substitutes and other biomaterials grew by 4.4% ...
... (Nasdaq: VRNM ), a pioneer in the ... today announced key 2010 accomplishments and 2011 Company ... a significant year of transition for Verenium as we ... building the next leading industrial enzymes company," said Carlos ...
Cached Medicine Technology:Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 2Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 3Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 4Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 5Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 6Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 7Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 8Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 9Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 10Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 11Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 12Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 13Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 14Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 15Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 16Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 17Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 18Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 19Reportlinker Adds European Markets for Dental Bone Graft Substitutes, Dental Membranes and Tissue Engineering 2011 20Verenium Announces 2010 Business Update and Outlook for 2011 2Verenium Announces 2010 Business Update and Outlook for 2011 3Verenium Announces 2010 Business Update and Outlook for 2011 4Verenium Announces 2010 Business Update and Outlook for 2011 5
(Date:10/30/2014)... Five months after their expansion, the AV ... branding and a website to accompany their recent change ... promotion to name partner earlier this year, Hodgkinson Street ... name and better reflect their combined litigation expertise. As ... to implement new branding reflects Hodgkinson Street Mepham’s collaborative ...
(Date:10/30/2014)... 2014 Radio listeners who indicate use ... the impact of traditional radio commercials and have overwhelmingly ... to influence a purchasing decision. , Those are some ... conducted by radio marketing company CRN International. The research ... results of respondents who indicated they have purchased or ...
(Date:10/30/2014)... Dennis Thompson HealthDay ... The Ebola outbreak in Liberia -- one of three West ... World Health Organization officials said Wednesday. Dr. Bruce Aylward, ... the number of burials in Liberia and no increase in ... global push to tame the epidemic may be making some ...
(Date:10/30/2014)... Horse Sense & Sensitivity ... special needs individuals in the Jacksonville area, will be ... from 10-2:00 p.m. at Bailey's Farm (2202 Bishop Estates ... public and is designed to raise awareness and funds ... HSS Round-Up is free. Ticket purchases will be required ...
(Date:10/30/2014)... California (PRWEB) October 30, 2014 REV'D ... bars are now available through a unique service called, ... site designed to empower the everyday athlete. The Feed ... best athletes and created a system to pass that ... to see REV’D® is now available on The Feed!” ...
Breaking Medicine News(10 mins):Health News:Hodgkinson Street Mepham Rebrands 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3Health News:Horse Sense & Sensitivity, Jacksonville Non-profit, To Hold 2nd Annual Round-Up 2Health News:Nutrition Experts at TheFeed.com Get REV'D 2Health News:Nutrition Experts at TheFeed.com Get REV'D 3
... dysfunctions- painful intercourse, sexual dissatisfaction and a multitude ... the patients and their doctors communicated better, most ... all women, as they go through menopause, will ... known as genital atrophy. ,This results in ...
... back with a vengeance. The killer disease of the past is ... partner in its destructive mission. Full-blown cases of AIDS coupled with ... in Africa alone. What is alarming is that the death rate ... no signs of the destruction slowing down. ,Health experts argue ...
... deaths due to asthma can be prevented if the ... disease. According to WHO, around 150 million people suffer ... due to the disease every year. Asthma is a ... characterized by sudden recurring attacks of labored breathing, chest ...
... that wound healing in depressed people is four times slower ... a place in the latest issue of the journal, “Psychosomatic ... on the rate of wound healing, according to the researchers. ... the immune system, which may keep a wound from healing ...
... injure the donor, it is now established without doubt that a ... person needing it. And the good news is that the donor ... his/her liver. ,Donation of a piece of the liver's right ... It is increasingly being performed in the West where the demand ...
... for the treatment of cancer has nearly,doubled during ... survey of pharmaceutical,companies.,Currently, 170 pharmaceutical and biotechnology firms ... treatment of various,cancers, up from 215 in 1995. ... and chemotherapy. For lung cancer, the leading cause ...
Cached Medicine News:
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: