Navigation Links
Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies
Date:7/30/2008

Nutriceutical Shown To Affect 9-Fold More Longevity Genes Than Resveratrol

Or A Limited-Calorie Diet Alone

- Independent Laboratory Animal Study

SAN DIMAS, Calif., July 30 /PRNewswire/ -- Researchers report that a proprietary nutriceutical matrix (Longevinex(R)) exhibits striking effects upon genes controlling energy metabolism, nine times broader than research-grade resveratrol and calorie restriction (mouse study -- Experimental Gerontology, early online edition, July 2008, for August hard-bound edition) at doses of resveratrol 17-320 fold lower than used in previous animal studies.

To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/resveratrolpartners/33656/

In a breakthrough study using laboratory mice, the matrix of nutraceuticals was found to produce more striking changes in gene expression, and influence more genes, in comparison to mice placed on research-grade resveratrol or a calorie restricted (CR) diet. The nutriceutical matrix favorably affected more biological pathways (by 3-4 fold) compared to CR. The study utilized microrrays which provide data on the expression level of over 20,000 genes. The study was conducted in mouse heart tissue.

The results of the mouse study were unexpected and surprising, pointing to a synergistic action when multiple natural molecules are employed. The nutriceutical matrix provided red wine molecules resveratrol and quercetin and the rice bran factor known as IP6. All three are mineral-chelating (key-lay-ting) molecules.

The short-term study not only showed the nutriceutical matrix exerted broader effects upon gene expression than CR or resveratrol, but molecularly mimicked gene patterns typically seen with long-term calorie restriction.

Of the 2829 genes significantly affected by any of the three dietary interventions employed (CR, resveratrol, or nutriceutical matrix), the limited calorie diet affected about 187 genes (7%), resveratrol about 224 genes (8%), while the nutriceutical matrix influenced 1711 genes (61%), over a 9-fold difference.

Recent studies that have captured the public's attention have focused on molecules that can slow aging and have been narrowly focused on the sirtuin family of genes and their activation by resveratrol, known as a red wine molecule. Recently researchers have reported that entire gene networks rather than single genes are involved in metabolic disorders, such as elevated blood sugar and cancer. Researchers report that gene array testing can detect genes affected by an unhealthy diet before there is change shown in the blood sample. [Nature March 16, 2008]

The nutriceutical matrix of natural molecules (Longevinex(R)) exhibited a much broader impact upon gene expression and more strikingly affected key genes, like Pdk4 and Pgc1 alpha, involved in mitochondrial energy metabolism.

Only the nutriceutical matrix, and not resveratrol or a long-term calorie restricted diet, upregulated the Foxo1 gene which enters the cell nucleus and promotes the expression of key longevity genes.

These effects were accomplished with a relatively low human equivalent dose of resveratrol. At about 1/15th the dose employed in a prior widely acclaimed mouse study (Nature Magazine Nov. 1, 2006) the nutriceutical matrix was able to exert more demonstrable genomic effects.

Prior animal studies employed the human equivalent of 1565, 360 and 343 milligrams of resveratrol to produce longevity effects. The nutriceutical matrix exerted 9-fold greater effect over the mouse genome at the equivalent daily human dose of resveratrol of 100 milligrams per day. According to this study, if data from mice is applicable to humans, some widely promoted mega-dose resveratrol pills, providing 500 to 1000 milligrams of resveratrol, would not exert as broad an effect over the human genome as the lower-dose resveratrol when provided in a matrix of other mineral-chelating natural molecules.

The discovery was made utilizing laser scanning technology to measure levels of messenger-RNA from thousands of genes in tissues obtained from test animals. Researchers used a commercially available GeneChip(R) (Affymetrix), which is about the size of a credit card.

Mice and humans share about 99% of their 30,000 genes. Most gene expression changes caused by aging are partially or completely prevented by CR. This discovery is suggestive of a day when humans could molecularly avert the effects of over-eating as well as slow or even reverse the aging process without having to deprive themselves of food.

A life-long CR diet is anticipated to influence more than the 200 genes shown in this short-term study, but the nutriceutical matrix exerted influence much sooner, raising the possibility that adherence long-term CR may not be required to obtain the same benefits.

The study was sponsored by Resveratrol Partners LLC, maker of Longevinex(R), a patent-applied-for nutriceutical (http://www.longevinex.com).

Resveratrol Partners LLC is a privately held Nevada limited liability company that markets its unique nutriceutical dietary supplement solely under the LONGEVINEX(R) trade name. Google has chosen to affix the stock symbol of another unrelated company to their GOOGLE NEWS listing for this press release, but Resveratrol Partners LLC, dba LONGEVINEX(R) has no affiliation with that or any other company.


'/>"/>
SOURCE Longevinex(R)
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Video: Sanford Healths Journey to Cure Type 1 Diabetes Receives Major Boost
2. Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
3. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
4. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
5. VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy
6. Video: New Results From One of the Worlds Largest Breast Cancer Trials Herald Hope for Thousands of Women
7. Video: Quest Diagnostics Health Trends(TM) Report Shows Significant Gap in Care for Patients With Chronic Kidney Disease
8. Video: Actress and New Mom Keri Russell Joins PKIDs to Launch Silence the Sounds of Pertussis Campaign
9. Video: The Arizona Heart Institute Announces the Largest Worldwide Experience with Endoluminal Grafting to Treat Thoracic Aortic Aneurysms and Related Pathologies
10. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
11. Video: New Research Discovers Independent Brain Networks Control Human Walking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... Bracket , a leading clinical trial technology ... outcomes platform, Bracket eCOA (SM) 6.0, at the 52 ... 30, 2016 in Philadelphia , Pennsylvania.  A ... product of its kind to fully integrate with RTSM, will ... 6.0 is a flexible platform for electronic clinical outcomes assessments ...
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... Pro X users can now reveal the media of their split screens with ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... Lewisville, TX (PRWEB) , ... June 25, 2016 , ... ... in the United States, named Dr. Sesan Ogunleye, as the Medical Director of its ... be the facility Medical Director of our new Mesquite location,” said Dr. James M. ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
Breaking Medicine News(10 mins):