Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Pri...( Nutriceutical Shown To Affect 9-Fold...),Health

Nutriceutical Shown To Affect 9-Fold More Longevity Genes Than Resveratrol

Or A Limited-Calorie Diet Alone

- Independent Laboratory Animal Study

SAN DIMAS, Calif., July 30 /PRNewswire/ -- Researchers report that a proprietary nutriceutical matrix (Longevinex(R)) exhibits striking effects upon genes controlling energy metabolism, nine times broader than research-grade resveratrol and calorie restriction (mouse study -- Experimental Gerontology, early online edition, July 2008, for August hard-bound edition) at doses of resveratrol 17-320 fold lower than used in previous animal studies.

To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/resveratrolpartners/33656/

In a breakthrough study using laboratory mice, the matrix of nutraceuticals was found to produce more striking changes in gene expression, and influence more genes, in comparison to mice placed on research-grade resveratrol or a calorie restricted (CR) diet. The nutriceutical matrix favorably affected more biological pathways (by 3-4 fold) compared to CR. The study utilized microrrays which provide data on the expression level of over 20,000 genes. The study was conducted in mouse heart tissue.

The results of the mouse study were unexpected and surprising, pointing to a synergistic action when multiple natural molecules are employed. The nutriceutical matrix provided red wine molecules resveratrol and quercetin and the rice bran factor known as IP6. All three are mineral-chelating (key-lay-ting) molecules.

The short-term study not only showed the nutriceutical matrix exerted broader effects upon gene expression than CR or resveratrol, but molecularly mimicked gene patterns typically seen with long-term calorie restriction.

Of the 2829 genes significantly affected by any of the three dietary interventions e
'/>"/>