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Video: MADIT-CRT Trial Results Provide Clinical Evidence That Cardiac Resynchronization Therapy Significantly Slows Heart Failure Progression
Date:9/1/2009

r a further list and description of these and other important risks and uncertainties that may affect our future operations, see Part I, Item 1A - Risk Factors in our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, which we may update in Part II, Item 1A - Risk Factors in Quarterly Reports on Form 10-Q we have filed or will file thereafter. We disclaim any intention or obligation to publicly update or revise any forward-looking statements to reflect any change in our expectations or in events, conditions, or circumstances on which those expectations may be based, or that may affect the likelihood that actual results will differ from those contained in the forward-looking statements. This cautionary statement is applicable to all forward-looking statements contained in this document.

(1) MADIT-CRT patients are high risk (asymptomatic or mildly symptomatic, New York Heart Association Class I and II). High-risk is defined as QRS width greater than or equal to 130 milliseconds and Left Ventricular Ejection Fraction less than or equal to 30%. The New York Heart Association clinical classifications of heart failure patients rank patients as Class I-II-III-IV, according to the degree of symptoms or functional limits, from asymptomatic to bed ridden.

(2) Left Ventricular Ejection Fraction (LVEF) is a measurement of how well the heart is pumping. People with healthy hearts usually have an LVEF of greater than or equal to 50%. Patients who were candidates for the MADIT-CRT study had an LVEF of less than or equal to 30%.

(3) Ischemic patients suffer from Coronary Artery Disease (CAD).

(4) Trials include MADIT, MADIT-II, CONTAK-CD, and COMPANION.

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