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Video: MADIT-CRT Trial Results Provide Clinical Evidence That Cardiac Resynchronization Therapy Significantly Slows Heart Failure Progression
Date:9/1/2009

therapy group would be dominated by a reduction in heart failure events and the data overwhelmingly confirm that," said Dr. Moss. "Furthermore, CRT-D therapy showed an equal benefit in both ischemic and non-ischemic(3) patients. The MADIT-CRT data are compelling and help bridge a clinical gap in our understanding of heart failure in Class I and II patients."

"The publication of the manuscript by the New England Journal of Medicine and the presentation of MADIT-CRT data at ESC highlight the importance of this study, which clearly demonstrates that CRT-D therapy slows the progression of heart failure, further delaying the onset of more severe and life-limiting conditions," said Fred Colen, President, Boston Scientific Cardiac Rhythm Management. "We look forward to working with the FDA as we seek approval for an expanded indication for our CRT-D devices, based on these strong results."

MADIT-CRT is the world's largest randomized study of NYHA Class I and II patients, with more than 1,800 patients enrolled at 110 centers in 14 countries. Currently, heart failure patients must be defined as NYHA Class III or IV to be indicated for CRT-D therapy. However, approximately 70 percent of all heart failure patients in the U.S. fall into Class I or II. Nearly 22 million people worldwide, including more than 5.5 million Americans, suffer from some form of heart failure.

MADIT-CRT is an important continuation of Boston Scientific's exclusive sponsorship of landmark clinical trials that have broken new ground and helped improve outcomes for high-risk cardiac patients worldwide. More than 80 percent of U.S. patients who receive an ICD or CRT-D were first indicated for this life-saving therapy through clinical research(4) sponsored by Boston Scientific.

Boston Scientific is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a broad range of interventional med
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SOURCE Boston Scientific Corporation
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