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Video: Large, Multi-Center Trial Demonstrates Comparable Accuracy for Virtual Colonoscopy and Standard Colonoscopy
Date:9/17/2008

th in men and women in the United States. Although screening recommendations vary somewhat, many recommend that adults aged 50 and older in the general population receive a colonoscopy every 10 years or more frequently, depending on known risk factors. Yet, despite the known benefits of screening, studies indicate that the majority of Americans age 50 and older are not being screened for the disease.

"Imaging advances such as virtual colonoscopy are an important step forward that could potentially increase the number of people who would agree to be screened. We hope, through continued imaging research and the development of molecular diagnostic techniques, that we will continue to improve our screening options in the years ahead and, as a result, continue to see a decline in the incidence of colorectal cancer," said NCI Director John E. Niederhuber, M.D.

"Previous single-site studies had indicated that CT colonography held promise in screening for colorectal cancer due to its accuracy, safety, cost-effectiveness, and patient acceptability. However, validation of the technique across multiple centers and radiologists was needed to provide more evidence of the exam's viability. The ACRIN trial has now validated that CT colonography could serve as an initial screening exam for the population in which screening is indicated," said Mei-Hsiu Chen, Ph.D., trial statistician, ACRIN Biostatistics and Data Management Center, Brown University, Providence, R.I.

In the ACRIN trial, the CT colonography findings were evaluated using standard colonoscopy as the reference standard. CT colonography was found to be highly accurate for the detection of intermediate and large polyps. Ninety percent of the polyps 1 centimeter or larger were detected by CT colonography. Even polyps as small as one half centimeter were detected by CT colonography with a high degree of accuracy. Since most colon cancers develop from polyps, and screening to find and remove these polyps
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SOURCE American College of Radiology Imaging Network (ACRIN)
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