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Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
Date:6/10/2008

42.8 27.8

Previous diet-treated

patients 62.0 58.3 30.8

Body Weight (kg) (Mean)

Baseline 92.6 92.1 93.3

Change from baseline -2.45 -2.05 1.12

Safety and Tolerability of Liraglutide

There were no major hypoglycemic episodes reported during the study. The rate of minor hypoglycemia was statistically significantly lower in both liraglutide dose groups compared with the glimepiride-treated group. The most common adverse events were nausea, diarrhea, and vomiting, and most were short-term and mild or moderate in severity.

About Liraglutide

Liraglutide is a once-daily analog of the naturally occurring hormone human Glucagon-Like Peptide-1 (GLP-1). Liraglutide works by stimulating the release of insulin only when glucose levels become too high and by inhibiting appetite. On 23 May 2008, Novo Nordisk submitted a New Drug Application to the Food and Drug Administration (FDA) in the US as well as a marketing authorization application to the European Medicines Agency (EMEA) in Europe, for the approval of liraglutide for the treatment of patients with type 2 diabetes.

About LEAD(TM) (Liraglutide Effect and Action in Diabetes)

The LEAD(TM) Program consists of five (four 26-week and one 52-week) randomized, controlled, double-blinded studies, involving more than 4000 patients with type 2 diabetes in 40 countries.

Novo Nordisk is a healthcare company and a world leader in diabetes care. In addition, Novo Nordisk has a leading position within areas such as haemostasis management, growth hormone therapy and hormone replacement therapy. Novo Nordisk manufactures and markets pharmaceutical products and services that make a significant difference to patients, the medical profession and society. With headquarters in Denmark, Novo Nordisk employs approximately 26,300 employees in 80 countrie
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SOURCE Novo Nordisk
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