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Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
Date:6/10/2008

gram for liraglutide.

The double-blinded, double-dummy, randomized, parallel group, actively-controlled, multicenter, multinational 52-week trial compared the efficacy and safety of two doses of liraglutide (1.2 and 1.8 mg once daily) to glimepiride (8 mg once daily) in patients with type 2 diabetes treated with diet/exercise or not more than half the maximum dose of one OAD for greater than or equal to two months. Patients treated with diet and exercise had HbA1c between 7.0% and 11.0%. Patients previously treated with oral monotherapy had an HbA1c between 7.0% and 10.0%.

The data showed that at both doses tested, liraglutide provided substantial improvement in glucose control from baseline and statistically significantly better glucose control than glimepiride. Patients previously treated with diet and exercise had greater decreases in HbA1c, as compared to subjects switched from an OAD to liraglutide.

In addition, there was significant weight loss, as compared to weight gain with glimepiride, and significantly greater reduction in systolic blood pressure with both liraglutide groups compared to glimepiride.

Results of a 52-week trial of liraglutide monotherapy in patients with inadequate glucose control from previous diet and exercise or treatment with one OAD:

Monotherapy

Liraglutide Liraglutide Glimepiride

1.8 mg 1.2 mg

N 246 251 248

HbA1c (%) (Mean)

Baseline 8.2 8.2 8.2

Change from baseline -1.14 -0.84 -0.51

Previous diet/exercise-

treated patients -1.60 -1.19 -0.88

Previous OAD-treated

patients -0.71 -0.47 -0.17

Patients (%)

achieving HbA1C <7%

All patients 50.9
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SOURCE Novo Nordisk
Copyright©2008 PR Newswire.
All rights reserved

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