Navigation Links
Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib
Date:3/30/2009

- Afinitor more than doubled time without tumor growth and reduced the risk of disease progression or death by 67% compared with placebo

- Only once-daily oral cancer treatment to directly target mTOR, a protein inside the cell that controls tumor cell division and blood vessel growth

- Phase III trials underway to explore potential of Afinitor in multiple additional cancers

EAST HANOVER, N.J., March 30 /PRNewswire/ -- Novartis announced today that Afinitor(R) (everolimus) tablets has been approved by the US Food and Drug Administration (FDA) for patients with advanced renal cell carcinoma (RCC) after failure of treatment with Sutent(R) (sunitinib)* or Nexavar(R) (sorafenib)**.

To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/novartis/36142

Prior to Afinitor, no other therapy has been studied in a Phase III trial in this patient population where there is an important unmet medical need(1). Sutent and Nexavar are commonly used as initial treatments for advanced RCC(2).

The approval is based on data that showed Afinitor, when compared with placebo, more than doubled the time without tumor growth or death in patients with advanced kidney cancer (4.9 vs. 1.9 months) and reduced the risk of disease progression or death by 67% (hazard ratio=0.33 with 95% confidence interval 0.25 to 0.43; P<0.0001)(3). Furthermore, additional data show that after 10 months of treatment with Afinitor, approximately 25% of patients still had no tumor growth(1) ***.

"This approval provides a new and useful tool for treating advanced renal cell cancer, representing an important step forward in managing this disease," said Robert J. Motzer, MD, attending physician, Memorial Sloan-Kettering Cancer Center, New York and principal investigator of the RECORD-1 trial, the bas
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
3. Video: The Arizona Heart Institute Announces the Largest Worldwide Experience with Endoluminal Grafting to Treat Thoracic Aortic Aneurysms and Related Pathologies
4. Video: Actress and New Mom Keri Russell Joins PKIDs to Launch Silence the Sounds of Pertussis Campaign
5. Video: Quest Diagnostics Health Trends(TM) Report Shows Significant Gap in Care for Patients With Chronic Kidney Disease
6. Video: New Results From One of the Worlds Largest Breast Cancer Trials Herald Hope for Thousands of Women
7. VIDEO: Femara(R) helps protect against return of breast cancer even when treatment starts several years after completing tamoxifen therapy
8. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
9. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
10. Video: Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, and Blood Pressure in Patients with Type 2 Diabetes
11. Video: Sanford Healths Journey to Cure Type 1 Diabetes Receives Major Boost
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... , May 21, 2015 ... ) has announced the addition of the ... Type (Ankle Replacement, Digit Replacement, Elbow Replacement, ... Forecast to 2019" report to their ... for knee replacement was valued at $4,470.9 ...
(Date:5/21/2015)... DUBLIN , May 21, 2015 /PRNewswire/ ... http://www.researchandmarkets.com/research/5x7nlz/arthroscopy ) has announced the addition of ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... to analyze and size the world market ... players and identifies trends impacting the market ...
(Date:5/21/2015)... 2015 The Pharmaceutical Care Management Association ... Part D offsets included in the Energy & ... "If the 21st Century Cures initiative can only be ... program – Medicare – then its costs outweigh ... road. "Leveraging payments to Part D ...
Breaking Medicine Technology:North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
... Non-infringing -- SCHENEFELD, Germany, Aug. 13 ... ... var shortURL = ""; BitlyCB.alertResponse = ... to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
... Aug. 13 Mylan Inc. (Nasdaq: www.mylan.com . ... This press release includes statements that constitute "forward-looking statements." ... provisions of the Private Securities Litigation Reform Act of ... actual future results may differ materially from those expressed ...
Cached Medicine Technology:German District Court Finds RENASYS™ GO NPWT System Non-infringing 2German District Court Finds RENASYS™ GO NPWT System Non-infringing 3German District Court Finds RENASYS™ GO NPWT System Non-infringing 4German District Court Finds RENASYS™ GO NPWT System Non-infringing 5German District Court Finds RENASYS™ GO NPWT System Non-infringing 6German District Court Finds RENASYS™ GO NPWT System Non-infringing 7German District Court Finds RENASYS™ GO NPWT System Non-infringing 8
(Date:5/25/2015)... Decora Preset 60 Minute Countdown Timer , a product ... City.’ The product helps in automatically switching off any electronic ... related electronic device is automatically turned off after the set ... “We are glad that this amazing product is now available ... Switch in just a few clicks. The product has been ...
(Date:5/24/2015)... TX (PRWEB) May 24, 2015 For ... Global and Chinese Enterokinase Industry, 2009-2019 Market Research Report ... it is an exhaustive study on the present market ... special insight into the growing Chinese market of this ... and the overall status of the manufacturers in this ...
(Date:5/24/2015)... York (PRWEB) May 24, 2015 ... lawsuits ( http://www.testosteronelawsuithub.com/ ) has scheduled its next ... of the multidistrict litigation. According to court documents ... of Illinois, the Conference will be convened on ... Testosterone Replacement Therapy Product Liability Litigation - MDL ...
(Date:5/24/2015)... Lake Geneva, WI (PRWEB) May 24, ... Bea Mercy Health System CEO ... their principal and honored at the ... event held April 15 at Geneva ... include (by school): ,     -Badger High ...
(Date:5/23/2015)... Dr. David Benvenuti, an experienced plastic surgeon ... new article to his website that takes an ... explained in the fascinating blog, he has recently had ... , Known as “gauging,” the technique involves placing larger and ... said will eventually stretch the holes out to incredible sizes. ...
Breaking Medicine News(10 mins):Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 2Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 3Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 4Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 3Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Dr. Benvenuti, a Plastic Surgeon in Newport Beach, CA, Posts New Article about Repairing Ear Gauges 2
... IBM (NYSE: IBM ... part of a network of global centers addressing the ... staff improve decision-making and provide higher quality care. , (Logo: ... hosted in the IBM Global Solution Center in Dallas and will ...
... Nov. 3 Democratic Senators Tom Harkin and Mary ... small business owner from Des Moines, Iowa; Gwendolyn Barnes, ... Brantley, a small business owner from Richmond, Virginia; and ... a press conference this morning to discuss how health ...
... received $3.9 million in Challenge grant funds as part ... NIH has designated at least $200 million in 2009 ... Grants in Health and Science Research. More than 800 ... program supports research on "Challenge Topics" which address specific ...
... 65 and over cast ballots for John McCain in 2008, ... presidential elections, according to an article in the latest issue ... 5). Author Robert Binstock, PhD, a renowned authority on ... Day exit poll conducted by Edison Media Research and Mitofsky ...
... growing number of C. difficile infections among ... potentially deadly stomach infection is on the rise outside ... , The germ that causes the condition, known as ... diarrhea and an inflammation of the colon, that can ...
... ... of Radiologic Technologists, National Radiologic Technology Week and All Year Long , ... Albuquerque, NM (Vocus) November 3, ... conditions, but how safe are they? Radiologic technologists, the skilled professionals who perform imaging ...
Cached Medicine News:Health News:IBM Launches Health Analytics Center 2Health News:IBM Launches Health Analytics Center 3Health News:IBM Launches Health Analytics Center 4Health News:Democratic Senators, Congresswoman, Small Business Owners Discuss Impact of Health Insurance Reform on Small Businesses 2Health News:Democratic Senators, Congresswoman, Small Business Owners Discuss Impact of Health Insurance Reform on Small Businesses 3Health News:Jefferson researchers receive $3.9 million in Challenge grants 2Health News:Jefferson researchers receive $3.9 million in Challenge grants 3Health News:Expert predicts possible shift in senior voting bloc 2Health News:Deadly Stomach Bug Making Inroads Outside Hospitals 2Health News:ASRT Offers Eight Tips for Great X-Ray Exams 2Health News:ASRT Offers Eight Tips for Great X-Ray Exams 3
... The Stellate Harmonie workstation is a ... processing loads, high quality video capability, and ... recording and review functions A framework that ... and archiving of data A centralized database ...
... the capability to acquire images in near-real ... Brightness and Contrast levels, Auto-windowing, Image Manipulation, ... Rhodium spectrum which is best adapted to ... Revolution flat panel digital detector, which is ...
... The P3000 heralds a new concept in ... binocular infrared optical system developed for the P2000. ... standard in which we have paid particular attention ... Our new system is extremely flexible, allowing ...
... Foramen ovale electrodes typically are ... and are positioned on the ... lobe. The ultra-thin 1.0 mm ... firm enough to allow guidance ...
Medicine Products: