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Vicus Therapeutics Announces Initiation of Phase 2 Trial to Evaluate VT-122 in Patients with Liver Cancer Receiving Nexavar
Date:12/27/2010

rapy, VT-122, is a combination of etodolac and propranolol.  VT-122 showed positive results in a Phase 2 clinical trial of lung cancer patients and is currently being evaluated in a Phase 2 clinical trial of liver cancer patients receiving Nexavar (sorafenib). For additional information about Vicus, please visit the company's website at www.vicustherapeutics.com.

(1) N. MacDonald. Cancer cachexia and targeting chronic inflammation: a unified approach to cancer treatment and palliative/supportive care.  J.Support.Oncol. 2007 Apr;5(4):157-62.

(2) D.C. McMillan. Systemic inflammation, nutritional status and survival in patients with cancer.  Curr Opin Clin Nutr Metab Care. 2009 May;12(3):223-6.

(3) G.S. Bhattacharyya et al.  Phase II study evaluating safety and efficacy of coadministering propranolol and etodolac for treating cancer cachexia.  J Clin Oncol. 28, 2010 (suppl; abstr e18059).

(4) M.J.  Muller. Hypermetabolism in clinically stable patients with liver cirrhosis. Am J Clin Nutr.  69: 1194– 1201, 1999.

(5) A. Gambardella et al. Intralipid infusion combined with propranolol administration has favorable metabolic effects in elderly malnourished cancer patients. Metabolism. 1999 Mar; 48(3):291-7.

(6) D.C. McMillan et al. A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. Br J Cancer. 1999. 79(3-4): p. 495-500.

(7) A. Glasner et al. Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. J Immunol. 2010. 184(5): p. 2449-57.


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