Navigation Links
Vical Expands Applications of Vaxfectin(R) Adjuvant for Infectious Disease and Cancer Vaccines; 80% to 100% of High-Dose Responders in H5N1 Clinical Trials Still Responding at 6 Months
Date:10/8/2008

fluenza vaccine generated broader, more balanced antibody responses than unformulated vaccine, and also generated influenza-specific T-cell responses. Adjusting the ratio of Vaxfectin(R) to vaccine drove substantial increases in either antibody or T-cell responses, without reducing the other type of response, compared with unformulated vaccine. The ability to favor primarily antibody or T-cell responses could provide important advantages in developing vaccines for specific applications.

H5N1 Pandemic Influenza Vaccine Phase 1 Trial Update

Vical reported in July that the company's Vaxfectin(R)-formulated H5N1 pandemic influenza DNA vaccines achieved potentially protective levels of antibody responses (H5 hemagglutination inhibition, or HI, titers of at least 40 and at least a four-fold increase from baseline) in at least 50% and up to 67% of evaluable subjects in the higher dose cohorts in a 100-subject Phase 1 trial.

Following injections at Days 0 and 21, responses peaked by Day 56, and more than 90% of the responders had sustained responses through the last measurement (Day 84) at the time of the preliminary analysis. Expanded data presented today shows that in the two cohorts receiving the highest H5 DNA dose (1 mg), 80% to 100% of the responders had sustained responses through Day 182. Similar results for a vaccine deployed during the early stages of a pandemic outbreak could provide substantial protection to the at-risk population and potentially alter the course of the pandemic.

These results support further development of Vaxfectin(R)-formulated DNA vaccines, and could position them as potential alternatives to conventional vaccines. DNA vaccines are fundamentally different from conventional vaccines because they do not contain any part of the virus itself, and may offer compelling advantages in response to a pandemic outbreak because of significantly reduced development and manufacturing times. Vical is currently seeking funding to
'/>"/>

SOURCE Vical Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
2. Multiple NIH Phase 2 HIV Vaccine Trials Using Vicals Technology Produce Encouraging Results
3. Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza
4. Spine Institute of Louisiana Offers Cervical Spine Motion Preservation as an Alternative to Fusion Surgery
5. Vical Licensee Sanofi-aventis Initiates Phase 3 Trial to Reduce Amputations
6. The First Annual Cervical Cancer/HPV Conference Tackles Controversial Vaccine Issues and Encourages Advocacy
7. Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant
8. New Study Shows Listeria Vaccine for Cervical Cancer Found Safe
9. Interim Safety Data Favorable for Vicals Phase 2 Trial of DNA Vaccine Against CMV
10. Vical Receives Payment from AnGes MG for Allovectin-7(R) Phase 3 Pivotal Trial
11. Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Alere Inc. ... rapid diagnostics, issued the following statement today in support ... Antibiotic-Resistant Bacteria. "As the global leader in ... for establishing a national strategy to address the serious ... to work with the Administration on initiatives to promote ...
(Date:9/19/2014)... -- Aufgrund der enormen Nachfrage seines ... aktualisiert, der jetzt auch die Jahre 2014 - ... pharmaserialisation.com , zeigt die Serialisierungsanforderungen weltweit und den ... Für international tätige Unternehmen geht es ... sondern darum, "wann" sie die neu in Kraft ...
(Date:9/19/2014)... 2014 Reductions in kidney failure ... in people with diabetes type 2 "Intensive ... for the kidneys." Australian researchers have discovered ... diabetes leads to persistent reductions in kidney failure many ... global study has found that, five and a half ...
Breaking Medicine Technology:Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3
... , BETHESDA, Md. , ... CHDX ), a leading independent American provider of Western,healthcare products and ... the Company plans to release third quarter fiscal year 2010,financial results ... will host a conference call at 8:00 am ET ...
... , RICHMOND, Calif. , ... announced that the company will release its fourth quarter and full year ... market closes. The press release will be followed by a conference call ... public via telephone and webcast. During the conference call, the company will ...
Cached Medicine Technology:Chindex International to Report Third Quarter Fiscal Year 2010 Financial Results 2Chindex International to Report Third Quarter Fiscal Year 2010 Financial Results 3Sangamo BioSciences Announces Fourth Quarter and Full Year 2009 Conference Call and Webcast 2
(Date:9/20/2014)... Recently, Best Cheap Hosting USA (best-cheap-hosting-usa.com), a ... website. The new site provides the latest reviews ... customers. Here, people can find a lot of ... it has recommended some excellent web hosting suppliers ... great web hosting suppliers, InMotion ( http://www.best-cheap-hosting-usa.com/go/InMotion/ ), ...
(Date:9/20/2014)... dentists have advised their patients against drinking coffee and wine. ... that advice and changing his stance after considering two recent ... oral health. “There’s good news and great news,” says Dr. ... protecting against gum disease, and red wine can help fight ... the September 2014 issue of Boston University School of ...
(Date:9/20/2014)... September 20, 2014 Recently, UWDress.com, an ... and women’s special occasion outfits, has launched a special ... company’s prom outfits are popular among worldwide clients. Now, ... wholesale prom dresses on its website. , ... customers from around the world. Great custom made items ...
(Date:9/20/2014)... New York, NY (PRWEB) September 20, 2014 ... million of their customers may have had their credit card ... late last year, spawning a slew of headline articles ... but those weren’t the only eye opening numbers. , ... numbers were stolen, almost like it’s a way to score ...
(Date:9/20/2014)... RBSEO Services, which has occupied a ... announced it provides an affordable website SEO (Search Engine ... announcement would benefit those new and old businesses struggling ... afford to pay a big amount for their website ... websites in top search results for their business keywords ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Launches Its New Website And Recommends InMotion To Worldwide People 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3Health News:Discounted 2014 Prom Dresses Provided By Innovative Company UWDress.com 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:RBSEO Services Announces Affordable Website SEO Service at Only $175 2
... ... ... 2009 -- The Texas Hospital Association (THA) has joined HEALTHeCAREERS Network,s ... hundreds of career Web sites., , , , ,"HEALTHeCAREERS is proud to welcome the ...
... HealthCare ... office in Glendora, bringing more healthcare options to the residents of eastern San Gabriel Valley. ... needs. , ... July 1, 2009-- HealthCare Partners recently opened a new Urgent Care Center (UCC) at the ...
... ... and Plays Multi-media Content Specific to Users Location. , ... Plano, TX (PRWEB) July 7, 2009 -- Symon ... of its InView Mobile iPhone application following a two week inaugural deployment ...
... ... deep endometriosis and accurately locate lesions prior to surgery, according to a new study published ... ... radiologists may be able to diagnose deep endometriosis and accurately locate lesions prior to surgery, ...
... Recent ... information to patients leads to reduced costs, improved practice workflow and increased patient satisfaction. ... Berkeley, CA ... education service, providing medical practices with time and cost savings and an easy-to-implement means ...
... LONDON, July 7 , ... and Media Doctor,and GP, Dr Rob Hicks, Call on Men to ... With the first innings of the Ashes commencing this ... Tufnell is calling,on British blokes to think about their health as ...
Cached Medicine News:Health News:Texas Hospital Association Endorses HEALTHeCAREERS Network 2Health News:HealthCare Partners Opens Glendora Urgent Care Center 2Health News:HealthCare Partners Opens Glendora Urgent Care Center 3Health News:Symon Announces Revolutionary New Application InView Mobile™ 2Health News:Symon Announces Revolutionary New Application InView Mobile™ 3Health News:MRI Accurately Depicts Deep Endometriosis 2Health News:MRI Accurately Depicts Deep Endometriosis 3Health News:Vivacare Patient Education Service Enhancements Save Medical Practices Time and Money and Improve Patient Satisfaction 2Health News:Vivacare Patient Education Service Enhancements Save Medical Practices Time and Money and Improve Patient Satisfaction 3Health News:Multimedia Release: British Men Think Talking About Impotence is "Just Not Cricket" 2Health News:Multimedia Release: British Men Think Talking About Impotence is "Just Not Cricket" 3Health News:Multimedia Release: British Men Think Talking About Impotence is "Just Not Cricket" 4Health News:Multimedia Release: British Men Think Talking About Impotence is "Just Not Cricket" 5
Straight shafts with polished finish. Teeth: 0.12 mm. Tying platform: 5.0 mm. Wide Serrated....
Angled 45 degree shafts with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Straight shafts with 1 x 2 teeth and 6 mm tying platform. Wide serrated handle with polished finish....
Straight shafts with 1 x 2 teeth and serrated handle with polished finish....
Medicine Products: