Navigation Links
Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial
Date:11/12/2008

SAN DIEGO, Nov. 12 /PRNewswire-FirstCall/ -- Vical Incorporated (Nasdaq: VICL) announced today that the company has completed enrollment of subjects in a Phase 2 trial of its therapeutic DNA vaccine designed to prevent cytomegalovirus (CMV) reactivation and disease in immunosuppressed stem cell transplant recipients. An interim analysis of immunogenicity data for the first 33 transplant recipients in the recipient-only arm of the study showed significant (p<0.05) post-transplant enhancement of CMV-specific T-cell responses in subjects receiving vaccine compared with subjects receiving placebo.

"These patients are highly immunosuppressed after transplant and, due to pre-existing infection, are at risk of CMV reactivation and the associated disease," said Ronald B. Moss, M.D., Vical's Vice President of Clinical Development. "The inducement of CMV-specific T-cell responses after transplant is encouraging, as others have noted that T-cell responses may be predictive of better control of CMV reactivation and disease. These encouraging immunogenicity data should translate into clinical benefit, and should be confirmed by clinical efficacy results in the second quarter of 2009."

The company conducted an interim immunogenicity analysis on post-transplant sera from the first 47 stem cell transplant recipients (33 in the recipient-only arm and 14 in the donor-recipient arm). The resulting data were analyzed by treatment group, but clinical sites and trial participants remain blinded to individual treatment codes. The results indicated significant enhancement of CMV-specific immunity in the recipient-only arm as measured by T-cell responses to the two CMV antigens targeted by the vaccine: pp65 (p<0.05) and gB (p<0.05). Results for the
'/>"/>

SOURCE Vical Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vicals Vaxfectin(R) Adjuvant
2. Vical Expands Applications of Vaxfectin(R) Adjuvant for Infectious Disease and Cancer Vaccines; 80% to 100% of High-Dose Responders in H5N1 Clinical Trials Still Responding at 6 Months
3. First Published Study of New HPV Test for Developing Countries Shows High Accuracy in Predicting Cervical Disease
4. Karolinska Institutet to Test Vicals Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
5. Karolinska Institute to Test Vicals Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
6. Vical Announces Breakthrough for Pandemic Influenza DNA Vaccines With Preliminary Human Data
7. Vical Advances RapidResponse(TM) DNA Vaccine Platform Under $6 Million Grant from NIH
8. Vical Receives $6.3 Million Payment for Continued Funding of Allovectin-7(R) Phase 3 Trial
9. Ending Cervical Cancer Featured at Summit; QIAGEN CEO Issues a Call to Global Women Leaders
10. Promise of Vicals CMV Vaccine Noted by Independent Experts
11. Study Finds QIAGENs HPV Test Offers Greater Long-term Protection From Cervical Disease Than the Pap
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ), ... sale of patented biopharmaceutical medicine, modernized traditional Chinese medicine ... announced the business and development progress at its Jiangchuan ... the September 2014 JCM application (No. 51268) for the ...
(Date:1/22/2015)... WOODBRIDGE, ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics ... company with a focus on Omega-3 therapies for cardiovascular disease ... summary of the Company,s accomplishments in 2014 and its outlook ... Dear Fellow Shareholders, We would like ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ) has ... Market by Product, Application, Technology, End User - Global ... The infectious disease diagnostics market is expected ... million by 2019 from $12,422.8 million in 2014. Increase ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3
... 13, 2011 A consortium comprised of funds advised by ... Plan Investment Board ("CPPIB") and the Public Sector Pension Investment ... a definitive agreement to acquire Kinetic Concepts, Inc. (NYSE: ... KCI is a U.S.-based medical device company focused ...
... New Technology Expands Treatment,Options ... to Liver,Cirrhosis . ... President of Market Access and,Reimbursement.   Sequana ... of its ALFApump™ System. Over,the coming months, the company will launch the product in ...
Cached Medicine Technology:Apax Partners, CPPIB and PSP Investments to Acquire Kinetic Concepts, Inc. for $68.50 per Share 2Apax Partners, CPPIB and PSP Investments to Acquire Kinetic Concepts, Inc. for $68.50 per Share 3Apax Partners, CPPIB and PSP Investments to Acquire Kinetic Concepts, Inc. for $68.50 per Share 4Sequana Medical Receives CE Mark Approval for the ALFApump™ System and Adds Key Executive to Team 2Sequana Medical Receives CE Mark Approval for the ALFApump™ System and Adds Key Executive to Team 3
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently ... View website of AngelWeddingDress.com to find more details. ... online for a bridal party. AngelWeddingDress offers a variety ... Its maternity wedding dresses are specially designed for 2015. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
(Date:1/22/2015)... EBSCO Information Services (EBSCO) and the ... in an effort to further promote visibility and adoption of ... long made AMA journals available via its subscription services, EBSCO ... Network. , Long known as both a subscription ...
(Date:1/22/2015)... VA (PRWEB) January 22, 2015 Step ... power at the Science Museum of Virginia. Wicked Plants, ... , Wicked Plants unearths 75 poisonous, carnivorous and diabolical ... through each room to uncover the biochemical, physical and ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... of Texas M. D. Anderson Cancer Center ... Knife (R) Perfexion(TM), an advanced radiosurgery ... lesions in the head in a single session, ... )"Leksell Gamma Knife Perfexion suits our clinical needs," ...
... CUREXO Technology Corporation, pioneer in medical robotics ... orthopaedic applications, which is focused on marketing its ... a premarket notification 510(k) application to the U.S. ... in the U.S. for use of its ROBODOC(R) ...
... Ill., Feb. 25 Abbott today announced the successful ... subsidiary Rainforest Acquisition Inc. to purchase all of the ... (AMO). The tender offer expired at midnight Eastern ... extended.The depositary for the tender offer has advised Abbott ...
... Maine, Feb. 25 Millions of Americans live without ... services provided by non-profit dental clinics become increasingly important. ... of Maine Dental Health for AllTM program is helping ... with an estimated 134,000 additional patient visits since its ...
... Feb. 25 The patent expiry of ... companies confronting intense competition from generics. CEOs ... alternative approaches to maintain the growth of ... )A focus on the market for niche ...
... Solutions, Adds Accomplished Financial Executive to its Senior Management Team ... ... Inc. (ATI) announced that Michael A. Brodeur has joined the company ... development and application of video-based telehealth solutions to advance patient care. ...
Cached Medicine News:Health News:M. D. Anderson Cancer Center Acquires Leksell Gamma Knife Perfexion for Targeted Brain Lesion Treatments 2Health News:M. D. Anderson Cancer Center Acquires Leksell Gamma Knife Perfexion for Targeted Brain Lesion Treatments 3Health News:CUREXO Technology Corporation Announces 510(k) Submission to FDA for Total Knee Arthroplasty Application 2Health News:Abbott Successfully Completes Tender Offer for Shares of Advanced Medical Optics 2Health News:Tom's of Maine Dental Health for All(TM) Program Works With Customers and Retailers to Provide Access to Oral Health Care 2Health News:Tom's of Maine Dental Health for All(TM) Program Works With Customers and Retailers to Provide Access to Oral Health Care 3Health News:Market for Niche Blockbusters Promises an Attractive Future for Large Pharmaceutical Companies, Indicates Frost & Sullivan 2Health News:Market for Niche Blockbusters Promises an Attractive Future for Large Pharmaceutical Companies, Indicates Frost & Sullivan 3Health News:Market for Niche Blockbusters Promises an Attractive Future for Large Pharmaceutical Companies, Indicates Frost & Sullivan 4Health News:American TeleCare, Inc. (ATI) Appoints Michael A. Brodeur as Chief Financial Officer 2Health News:American TeleCare, Inc. (ATI) Appoints Michael A. Brodeur as Chief Financial Officer 3
... system is the lowest profile plate clinically ... integrated lock mechanism, which is designed to ... appreciate the narrow width, which decreases the ... system also offers easy to use instrumentation ...
... supplies, and all patient follow-ups. This allows your ... patient up in your office (analogous to putting ... component, for interpreting the reports PDSHEART provides you. ... full access to your reports 24 hours per ...
... leading provider of Telemedicine monitoring and ... outstanding service commitment to patients and ... transtelephonic testing devices that provide enhanced ... using standard telephone lines. TransMedEx's product ...
... Raytel Cardiac Services is a ... uniquely qualified people, combined with state-of-the-art ... clinical information that supports healthcare professionals ... Cardiac Services uses telecommunications and ECG ...
Medicine Products: