Navigation Links
Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week
Date:10/2/2007

Variety of new applications spans paleogenomics, paired-end mapping, and

gene expression analysis

BRANFORD, Conn., Oct. 2 /PRNewswire/ -- 454 Life Sciences, a Roche company, is the subject of three ground-breaking studies published last week in Science, all of which employed the company's Genome Sequencer(TM) system. The studies, entitled "Paired-End Mapping Reveals Extensive Genomic Structural Variation in Humans", "Wasp Brain Gene Expression Supports an Evolutionary Link between Maternal Behavior and Eusociality", and "Whole-Genome Shotgun Sequencing of Mitochondria from Ancient Hair Shafts" appear online (ahead of print) in Science Express.

The three publications span a number of research fields and sequencing applications. The diversity of the publications illustrate the flexibility of 454 Sequencing and its ability to deliver scientifically relevant results in any research field employing DNA sequencing. The studies relied on long, highly accurate reads, including paired reads, characteristic of 454 Sequencing.

Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism (SNP), variations that involve just one nucleotide. However, the study, "Paired-End Mapping Reveals Extensive Genomic Structural Variation in Humans," published today suggests that structural variation is responsible for a larger number of differences between the genomes of two individuals than SNPs. Furthermore, structural variation may have notable physical effects on an individual. The role that SV plays in human variability has not been well understood because of imprecise technology used in previous research. The novel approach described today in Science, called Paired End Mapping (PEM), used 454 Sequencing to comprehensively study SV at an unmatched level of resolution, detecting most of the structural variation in the human genome.

The presence of worker wasps that forgo reproduction
'/>"/>

SOURCE 454 Life Sciences
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Study Shows Ixabepilone Demonstrated Clear Activity in Patients with Metastatic Breast Cancer Resistant to Anthracycline, Taxane, and Capecitabine
2. Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic Control in Subjects with Type 2 Diabetes Compared to Metformin Alone
3. Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic Control in Subjects with Type 2 Diabetes Compared to Metformin Alone
4. Investigational Study Demonstrated a Re-Establishment of Clinical Improvement with Orencia (Abatacept) in Children with Juvenile Idiopathic Arthritis upon Re-Introduction of Therapy
5. Study Demonstrated Rozerem (ramelteon) Does Not Affect Middle-of-the-Night Balance in Older Adults with Insomnia
6. Repros Reports That Proellex Has Demonstrated Superior Efficacy and Safety in Endometriosis When Compared to Standard of Drug Care
7. Organons Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial as Compared to Neostigmine
8. Organons Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial Compared to Neostigmine
9. Trexima (Sumatriptan/Naproxen Sodium) Demonstrated Migraine-Free Response Across Multiple Attacks
10. Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
11. Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... Aug. 27, 2015  BioElectronics Corporation (OTC Pink: BIEL), the ... three abstracts featuring the use of ActiPatch®, its novel ... th Congress of the European Pain Federation EFIC®, ... September 2015. The Company will also be exhibiting at ... Gianluca Bagnato , department clinical and experimental rheumatology from ...
(Date:8/27/2015)... Aug. 27, 2015   Americord Registry , a ... and placenta tissue banking company, announced today ... e-commerce website. This new website makes the expecting parent,s ... interactive shopping cart and checkout process. Logo ... blood banking websites make this service difficult to purchase ...
(Date:8/27/2015)... 27, 2015  Zimmer Biomet Holdings, Inc. (NYSE and ... that it will be participating in the Goldman Sachs ... Sachs offices in London on ... Founded in 1927 and headquartered in Warsaw, ... in musculoskeletal healthcare.  We design, manufacture and market orthopaedic ...
Breaking Medicine Technology:BioElectronics Selected to Present its Pain Research and Devices at the European Pain Federation Conference 2Cord Blood Bank Revolutionizes Process of Online Cord Blood Banking 2
... Symmetry Medical Inc. (NYSE: SMA ), a leading ... and other medical markets, announced today that it has entered ... November 3, 2010.  The credit facility includes an "accordion feature" ... million. The credit facility has a term of five years. ...
... Nov. 3, 2010 Aethlon Medical, Inc. (OTC ... in developing therapeutic filtration devices to address infectious ... present tomorrow at the at the Singular Research ... Los Angeles. (Photo:   http://photos.prnewswire.com/prnh/20090325/LA88762LOGO-b ) ...
Cached Medicine Technology:Symmetry Medical Closes $200 Million Credit Facility 2Symmetry Medical Closes $200 Million Credit Facility 3Aethlon Medical to Present at the Singular Research Fifth Annual 'Best of the Uncovereds Conference' 2Aethlon Medical to Present at the Singular Research Fifth Annual 'Best of the Uncovereds Conference' 3Aethlon Medical to Present at the Singular Research Fifth Annual 'Best of the Uncovereds Conference' 4
(Date:8/27/2015)... ... ... About 10 percent of mothers experienced chronic, persistent depressive ... than 1,800 people, displacing hundreds of thousands and causing widespread damage estimated at ... most people don’t develop persistent depression after a major disaster like that, a ...
(Date:8/27/2015)... ... ... The Naderi Center is proud to announce that its own Dr. Jessica ... fat. The first and only Food and Drug Administration (FDA) approved treatment for ... only Board Certified surgeon in the D.C., Maryland, Virginia area to offer this innovative, ...
(Date:8/27/2015)... ... August 27, 2015 , ... ... its Krames Patient Education content is ICD-10 ready and available to all clients. ... new ICD-10 code sets, which are more targeted and return a more comprehensive ...
(Date:8/27/2015)... ... 2015 , ... Zensah®, the premium athletic compression company, is ... in the Women’s Tennis Association (WTA). Glushko competes in tennis tournaments around the ... a focus on technology and comfort, Zensah® has developed compression gear to help ...
(Date:8/27/2015)... ... ... In addition to its existing Doctor of Philosophy in Leadership and Doctor ... main campus in Reading: Doctor of Nursing Practice. , Alvernia’s Doctor of Nursing ... for the highest level of clinical nursing practice. , “Our vision is to ...
Breaking Medicine News(10 mins):Health News:About 10 Percent of Mothers Experienced Depression Two Years After Hurricane Katrina, New Study Shows 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 2Health News:Noninvasive Double Chin Elimination Now Available in Herndon and Chevy Chase 3Health News:StayWell announces all health content is ICD-10 ready 2Health News:StayWell announces all health content is ICD-10 ready 3Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 2Health News:Zensah® Compression Announces Partnership with WTA Tennis Professional Athlete, Julia Glushko 3Health News:Alvernia University Now Offering Three Doctoral Degree Programs 2
... under the Revised National TB Control Programme (RNTCP) aims ... treatment and diagnostic services to all tuberculosis patients. It ... HIV-positive people are more prone to contracting tuberculosis. Hence ... plan to tackle this issue and multi-drug resistant cases. ...
... and minds of various people world over. But now it ... detox products are to be investigated by the British government. ... attention to some of their medical claims. , ,The ... based on investigations by Real Story's Doctors on a Detox ...
... attempting of suicide is high among the children of men ... the University of British Columbia and several other institutions in ... working or had worked at sawmills in British Columbia - ... ,They collected data on the men's history of employment, their ...
... for calming the nervous, can act otherwise leading ... ,Substances like diphenhydramine, which can be ... says Ursula Sellerberg, spokeswoman for the Federal Organization ... ,Diazepam, the main ingredient in valium, can ...
... new studies, researchers claim that more people could be ... cow disease than previously thought after new evidence emerged ... developing. // According to the scientists from Edinburgh a ... to pass through blood transfusions and surgical instruments, can ...
... market in Norwich is a non-referral drop-in-center aimed at people, ... after its fallen apart. // Founded in 1994, the centre ... mental health charity Rethink. The centre will be launching an ... and shallowness, that follows mental illness. ,The place is ...
Cached Medicine News:Health News:India to Implement National Action Plan against TB-HIV 2Health News:Mad Cow Disease – Worst Is Yet To com 2Health News:Bridging People’s lives, Post Upheava 2
... the first polypropylene mesh specifically designed ... directly addresses the critical issues associated ... delivers maximum visibility, enhanced maneuverability and ... through the trocar.,Visilex mesh is the ...
... technique, recommended for the treatment of ... direct inguinal hernias, provides significant advantages ... less overall dissection and is utilized ... The result is increased patient comfort, ...
... longest available wavelength with a unique flat ... efficacy. The unique flat beam profile consistently ... all targeted structures. The Lyra-I uniquely avoids ... Lyra-I patients are protected by patented continuous ...
... nonabsorbable knitted product for use in ... a highly flexible and compliant material ... surgical adaptability, along with maximal porosity ... Mesh is constructed from polyethylene terephthalate, ...
Medicine Products: