Navigation Links
VeriStrat® Test Identifies Lung Cancer Patients Benefiting from Combination Therapy
Date:11/19/2010

BROOMFIELD, Colo., Nov. 19, 2010 /PRNewswire/ -- Results from the VeriStrat analysis of a phase II trial of first line erlotinib in combination with sorafenib in patients with advanced non-small cell lung cancer (NSCLC) were presented today at the 22nd EORTC-NCI-AACR Symposium on Molecular Targets in Cancer Therapeutics being held in Berlin, Germany by Egbert Smit, MD, PhD of the VU Medical Center, Amsterdam, The Netherlands.  The intention of the biomarker analysis was to evaluate the ability of the blood-based test, VeriStrat, to predict patient outcomes with the erlotinib plus sorafenib combination regimen.

Forty-nine of 50 patients from the study had pretreatment serum samples available for analysis.  VeriStrat analysis classified 33 (67%) as likely to have "good" outcomes and 15 (31%) as likely to have "poor" outcomes.  Only one sample was classified as indeterminate.  VeriStrat Good patients had a significant improvement in overall survival compared with VeriStrat Poor patients (Hazard ratio= 0.30; CI: 0.12-0.74).  The median overall survival for VeriStrat Good patients was 13.7 months compared to 5.6 months for VeriStrat Poor patients. 

Researchers concluded that the proteomic test, VeriStrat, may identify a subset of patients that derive significant clinical benefit from first- line treatment of advanced NSCLC with dual targeted therapies.  Prospective studies are planned.

"This is the first study to demonstrate that a biomarker can identify patients who are likely to benefit from the erlotinib plus sorafenib combination," stated Egbert Smit, MD, PhD.  "This is exciting for lung cancer patients as the all-oral combination may be more tolerable than traditional platinum-based regimens, with similar efficacy.  More research is needed to fully define the role of this biomarker and identify the specific groups of patients that this combination may benefit."

About NSCLC:  As reporte
'/>"/>

SOURCE Biodesix
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. St. Jude Identifies the Specific Cell That Causes Eye Cancer, Disproving Long-Held Theory
2. New Analysis from 14 Countries Identifies Drug Access Priorities to Achieve 2010 AIDS Treatment Target
3. Research Identifies Need for Improved Understanding of Sickle Cell Disease in Adulthood
4. Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus
5. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
6. JACC Identifies DEFER with 5-year Outcomes as Landmark Trial
7. Mayo Clinic Study Identifies Potential Causes of Young-Onset Dementia
8. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
9. Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594
10. Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer
11. Rosetta Genomics Identifies Potential microRNA Biomarkers in Blood Serum
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2014)...  Actavis plc (NYSE: ACT ), a leading ... , CEO and President of Actavis, will provide an overview ... Global Healthcare Conference 2014 in New York, NY ... The presentation will take place on Tuesday, September 9, ... New York, 109 East 42 nd Street, ...
(Date:8/26/2014)... Aug. 26, 2014 Global design and architecture firm NBBJ announced ... China . Principal Rudy Widjaja will lead planning ... he will draw on his experience with healthcare clients in ... the United States , as well as the firm,s global network ... China healthcare practice comes at a time when the scope ...
(Date:8/26/2014)... 2014 Equashield ( www.equashield.com ), ... for hazardous drugs, announced today it has appointed a ... around the United States . The ... nurses, awareness of issues around occupational exposure to hazardous ... systems for hazardous drug transfer. "As a ...
Breaking Medicine Technology:Actavis to Present at Morgan Stanley Global Healthcare Conference 2014 2Leading Architectural Design Firm NBBJ Launches Healthcare Practice in China 2Leading Architectural Design Firm NBBJ Launches Healthcare Practice in China 3Leading Architectural Design Firm NBBJ Launches Healthcare Practice in China 4Leading Architectural Design Firm NBBJ Launches Healthcare Practice in China 5Equashield Appoints Nurse Advisory Council 2Equashield Appoints Nurse Advisory Council 3Equashield Appoints Nurse Advisory Council 4
... ... International, an independent nonprofit research and development institute, has received two ... the National Institutes of Health (NIH), to develop a stationary X-ray ... is intended to improve three-dimensional imaging technology, which will make it ...
... Ad, " This is Medicare and America at ... WASHINGTON, Dec. 9 The SCOOTER Store today launched a ... and cost savings associated with Medicare,s Power Mobility Benefit, which ... to receive power wheelchairs. , With budget cuts likely in ...
Cached Medicine Technology:SRI International Receives National Institutes of Health Grants to Develop Improved Tomographic Imaging Technology 2SRI International Receives National Institutes of Health Grants to Develop Improved Tomographic Imaging Technology 3The SCOOTER Store Launches New Advertising Highlighting the Value and Cost Savings From Medicare's Power Mobility Benefit 2
(Date:8/27/2014)... Top10BestSEOHosting.com compares many popular hosting ... the most recommended suppliers for webmasters who want ... “GreenGeeks and GoDaddy provide stellar hosting products and ... have managed to provide a wide range of ... of use that helps diminish the inherent complexity ...
(Date:8/27/2014)... "It can be quite difficult to wipe one’s ... inventor from Lehigh Acres, Fla.," so I designed an ... task." He then created a prototype of his idea. ... to wipe and clean the behind thoroughly after going ... well as prevents direct contact with waste or anal ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 ... governance, and compliance software solutions for next-generation social ... Inc. magazine’s Inc. 500|5000, an exclusive ranking of ... consecutive year. AvePoint joins brands such as Alex ... 2014 edition. , This underscores continued growth ...
(Date:8/27/2014)... ALS Insights is a dedicated website created by ... a series of compelling interviews with people who have ... in searing honesty, about issues such as acceptance vs. ... happened in the final days and how the families ... dramatic increase in public awareness and financial support for ...
(Date:8/27/2014)... York, NY (PRWEB) August 27, 2014 Overcoming ... failure, he finally found his niche. The Women’s Radio Network, ... Armstrong for his continued support and dedication to the WRNW1 ... be able to have such a positive atmosphere.” After KC ... on Sirius XM of the Howard Stern show, “Howard 100 ...
Breaking Medicine News(10 mins):Health News:Excellent Hosting Suppliers Recommended By Top10BestSEOHosting.com 2Health News:InventHelp Client's Device Helps a User Wipe Thoroughly After Going to the Bathroom (HLW-1300) 2Health News:Inc. Magazine Names AvePoint to the Inc. 500|5000 List of Fastest Growing American Companies for the Fifth Consecutive Year 2Health News:Inc. Magazine Names AvePoint to the Inc. 500|5000 List of Fastest Growing American Companies for the Fifth Consecutive Year 3Health News:ALS Insights Launched as Web Resource of Interviews and Information 2Health News:The Women's Radio Network, WRNW1, Signs KC Armstrong to a Multi-Million Dollar Contract 2
... in New York, New Jersey, , THURSDAY, Feb. 11 (HealthDay ... eastern United States, even some of those who were vaccinated ... A study released Thursday by the U.S. Centers for Disease ... confined to an orthodox Hasidic Jewish group. The outbreak started ...
... ... FAB-HOMES ™, a green home design studio based in Vancouver, Canada, ... American market. Fab-homes™ showcases a selection of modern, European dwellings planned along ... to 90% less energy for heating, cooling and building operation than a ...
... ... a mouse , ... Fl (Vocus) February 11, 2010 -- Everyone knows February is heart month. From frilly Valentine ... of women’s heart disease, clearly this month is dedicated to hearts. Not so obvious are ...
... The Autism ... and other stakeholders to support attendance at the International Meeting for Autism Research (IMFAR), to ... ... not-for-profit organization dedicated to supporting and funding autism research, announced tody that is offering a ...
... , The American Red Cross ... PHILADELPHIA , Feb. 11 Wednesday,s blizzard-like conditions ... Penn-Jersey Region.  The American Red Cross expected to see 1,300 ... drives were cancelled. , (Logo:   http://www.newscom.com/cgi-bin/prnh/20081216/DC52619LOGO  ) ...
... , Partnership Encourages Americans to Get Educated During National ... , Feb. 11 According to a ... initiative, close to half of Americans (44 percent) are "WannabeWELLs"—that is, ... they may not know where to start. , In honor ...
Cached Medicine News:Health News:Vaccine Not Fail-Safe in Ongoing Mumps Outbreak 2Health News:Vaccine Not Fail-Safe in Ongoing Mumps Outbreak 3Health News:FAB-HOMES™ Presents First Passive House Collection 2Health News:FAB-HOMES™ Presents First Passive House Collection 3Health News:PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February 2Health News:Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders 2Health News:Autism Science Foundation Offers IMFAR Grants to Autism Stakeholders 3Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 2Health News:Local Blood Supply Impacted by Wednesday's Severe Snow Storm 3Health News:Helping Turn "WannabeWELLS" into Wise Consumers 2Health News:Helping Turn "WannabeWELLS" into Wise Consumers 3Health News:Helping Turn "WannabeWELLS" into Wise Consumers 4Health News:Helping Turn "WannabeWELLS" into Wise Consumers 5Health News:Helping Turn "WannabeWELLS" into Wise Consumers 6
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: