Navigation Links
Ventana Medical Systems, Inc. develops first-ever fully automated dual-stain technique for miRNA and protein detection in cancer

TUCSON, Ariz., Sept. 6, 2012 /PRNewswire/ -- Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, is introducing a first-of-its-kind fully-automated staining technique that will allow researchers to examine miRNAs and proteins related to cancer in the same section of tumor tissue. Detecting miRNAs and proteins together, in the context of the tumor microenvironment, allows researchers to visualize the association of oncogenic protein expression to those miRNAs involved in the regulation of the mRNA species responsible for protein production. This is exciting news for researchers who have been studying how this relationship plays a role in driving tumor cell growth in many tumor types including breast, lung, prostate and colorectal cancers.

Dr. Thomas Grogan, M.D., pioneering pathologist and founder of Ventana Medical Systems, Inc., is highly optimistic about the promise of this technique. "With this exciting technical breakthrough, we can now judge with a standard light microscope the link between miRNA and associated proteins in full cellular context. It will now reveal matters like message/protein dysfunction and heterogeneity. This then will add greatly to our understanding of the mechanisms of cancer biology and help direct new better informed targeted therapies."

James W. Welsh, M.D., assistant professor in the Department of Radiology at The University of Texas MD Anderson Cancer Center, believes this new technology could eventually work as a companion diagnostic tool for future miRNA pathway targeting drugs. "For the first time, using this technique, researchers will be able to observe the relationships between specific miRNAs and their known oncogenic protein targets," says Dr. Welsh. "In lung cancer, we've begun to identify pairs of miRNAs and proteins that we believe play a role in treatment resistance and metastasis; utilizing this new protocol will hopefully allow us to better understand the correlation between the two." In the future, Dr. Welsh adds, miRNAs could be utilized as biomarkers or therapeutics for lung cancer as well as other solid tumors.

Watch the video of Dr. Welsh's full comments.

Unlike traditional enzymatic retrieval, which is the current industry standard for miRNA in situ hybridization (ISH), the new technique from Ventana uses non-enzymatic pre-treatments, enabling the detection of both targets while preserving tissue morphology. Developed for use on the DISCOVERY ULTRA instrument, the application is fully automated, allowing for greater reproducibility of target detection.

The DISCOVERY ULTRA immunohistochemistry (IHC) and in situ hybridization (ISH) systems from Ventana offer full automation, along with unsurpassed freedom and flexibility. For scientists and research professionals who require more than conventional IHC and ISH research methods can offer, the DISCOVERY ULTRA system provides exceptional, reproducible results to help scientific inventions become medical innovations.

1The Ventana miRNA and protein dual-stain technique and the DISCOVERY ULTRA System are for Research Use Only.  Not for use in diagnostic procedures.

About Ventana Medical Systems, Inc.
Ventana Medical Systems, Inc. ("VMSI") (SIX: RO, ROG; OTCQX: RHHBY), a member of the Roche Group, innovates and manufactures instruments and reagents that automate tissue processing and slide staining for cancer diagnostics. VENTANA solutions are used in clinical histology and drug development research laboratories worldwide. The company's intuitive, integrated staining, workflow management platforms, and digital pathology solutions optimize laboratory efficiencies to reduce errors, support diagnosis and inform treatment decisions for anatomic pathology professionals. Together with Roche, VMSI is driving Personalized Healthcare through accelerated drug discovery and the development of "companion diagnostics" to identify the patients most likely to respond favorably to specific therapies.

Visit to learn more.

VENTANA, the VENTANA logo, and DISCOVERY are trademarks of Roche.

Ventana Medical Systems, Inc.
Empowering | Innovation

VMSI Media Relations
Jacqueline Bucher
Senior Director, Corporate Communications
Phone: 520-877-7288

Request High Resolution Files

© 2012 Ventana Medical Systems, Inc.
VENTANA and the VENTANA Logo are trademarks of Roche.
All other trademarks are the property of their respective owners.

Related Links:
Dr. Welsh's testimonial 
Request High Resolution Files
Follow us on Twitter
Join our Network on LinkedIn

SOURCE Ventana Medical Systems, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Ventana Supports World Patient Safety Day, July 25
2. Ventana licenses Gen-Probe IP for measuring ERG protein in prostate cancer patients
3. Ventana Receives FDA Clearance for p53 (DO-7) Image Analysis and Digital Read Applications
4. Medical Alarm Retires Last of Convertible Preferred Stock
5. Concord Medical Responds to Unusual Market Activity in its Stock
6. International Spine Products Manufacturer Featured in Upcoming US Business Executive Publication -
7. Medical Alarm Provides Investor Update -- Company Surpassing Previous Record Order Levels as Consumer Interest Accelerates
8. Launches New Medical Education Management Solutions That Meet ACGME NAS Accreditation Requirements
9. Fall Alert Announces Its New Medical Alert Systems Website
10. Surefire Medicals Infusion System For Embolization Procedures Receives CE Mark Approval
11. Magnalight Releases Handheld Infrared Light for Medical Applications
Post Your Comments:
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. ... big data solutions, today announced that its MyDario product is expected to ... TV listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, ... ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) will ... during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual ... F. Collen, a pioneer in the field of medical informatics, this prestigious award is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
Breaking Medicine News(10 mins):