Navigation Links
Ventana Medical Systems, Inc. develops first-ever fully automated dual-stain technique for miRNA and protein detection in cancer

TUCSON, Ariz., Sept. 6, 2012 /PRNewswire/ -- Ventana Medical Systems, Inc. (Ventana), a member of the Roche Group, is introducing a first-of-its-kind fully-automated staining technique that will allow researchers to examine miRNAs and proteins related to cancer in the same section of tumor tissue. Detecting miRNAs and proteins together, in the context of the tumor microenvironment, allows researchers to visualize the association of oncogenic protein expression to those miRNAs involved in the regulation of the mRNA species responsible for protein production. This is exciting news for researchers who have been studying how this relationship plays a role in driving tumor cell growth in many tumor types including breast, lung, prostate and colorectal cancers.

Dr. Thomas Grogan, M.D., pioneering pathologist and founder of Ventana Medical Systems, Inc., is highly optimistic about the promise of this technique. "With this exciting technical breakthrough, we can now judge with a standard light microscope the link between miRNA and associated proteins in full cellular context. It will now reveal matters like message/protein dysfunction and heterogeneity. This then will add greatly to our understanding of the mechanisms of cancer biology and help direct new better informed targeted therapies."

James W. Welsh, M.D., assistant professor in the Department of Radiology at The University of Texas MD Anderson Cancer Center, believes this new technology could eventually work as a companion diagnostic tool for future miRNA pathway targeting drugs. "For the first time, using this technique, researchers will be able to observe the relationships between specific miRNAs and their known oncogenic protein targets," says Dr. Welsh. "In lung cancer, we've begun to identify pairs of miRNAs and proteins that we believe play a role in treatment resistance and metastasis; utilizing this new protocol will hopefully allow us to better understand the correlation between the two." In the future, Dr. Welsh adds, miRNAs could be utilized as biomarkers or therapeutics for lung cancer as well as other solid tumors.

Watch the video of Dr. Welsh's full comments.

Unlike traditional enzymatic retrieval, which is the current industry standard for miRNA in situ hybridization (ISH), the new technique from Ventana uses non-enzymatic pre-treatments, enabling the detection of both targets while preserving tissue morphology. Developed for use on the DISCOVERY ULTRA instrument, the application is fully automated, allowing for greater reproducibility of target detection.

The DISCOVERY ULTRA immunohistochemistry (IHC) and in situ hybridization (ISH) systems from Ventana offer full automation, along with unsurpassed freedom and flexibility. For scientists and research professionals who require more than conventional IHC and ISH research methods can offer, the DISCOVERY ULTRA system provides exceptional, reproducible results to help scientific inventions become medical innovations.

1The Ventana miRNA and protein dual-stain technique and the DISCOVERY ULTRA System are for Research Use Only.  Not for use in diagnostic procedures.

About Ventana Medical Systems, Inc.
Ventana Medical Systems, Inc. ("VMSI") (SIX: RO, ROG; OTCQX: RHHBY), a member of the Roche Group, innovates and manufactures instruments and reagents that automate tissue processing and slide staining for cancer diagnostics. VENTANA solutions are used in clinical histology and drug development research laboratories worldwide. The company's intuitive, integrated staining, workflow management platforms, and digital pathology solutions optimize laboratory efficiencies to reduce errors, support diagnosis and inform treatment decisions for anatomic pathology professionals. Together with Roche, VMSI is driving Personalized Healthcare through accelerated drug discovery and the development of "companion diagnostics" to identify the patients most likely to respond favorably to specific therapies.

Visit to learn more.

VENTANA, the VENTANA logo, and DISCOVERY are trademarks of Roche.

Ventana Medical Systems, Inc.
Empowering | Innovation

VMSI Media Relations
Jacqueline Bucher
Senior Director, Corporate Communications
Phone: 520-877-7288

Request High Resolution Files

© 2012 Ventana Medical Systems, Inc.
VENTANA and the VENTANA Logo are trademarks of Roche.
All other trademarks are the property of their respective owners.

Related Links:
Dr. Welsh's testimonial 
Request High Resolution Files
Follow us on Twitter
Join our Network on LinkedIn

SOURCE Ventana Medical Systems, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Ventana Supports World Patient Safety Day, July 25
2. Ventana licenses Gen-Probe IP for measuring ERG protein in prostate cancer patients
3. Ventana Receives FDA Clearance for p53 (DO-7) Image Analysis and Digital Read Applications
4. Medical Alarm Retires Last of Convertible Preferred Stock
5. Concord Medical Responds to Unusual Market Activity in its Stock
6. International Spine Products Manufacturer Featured in Upcoming US Business Executive Publication -
7. Medical Alarm Provides Investor Update -- Company Surpassing Previous Record Order Levels as Consumer Interest Accelerates
8. Launches New Medical Education Management Solutions That Meet ACGME NAS Accreditation Requirements
9. Fall Alert Announces Its New Medical Alert Systems Website
10. Surefire Medicals Infusion System For Embolization Procedures Receives CE Mark Approval
11. Magnalight Releases Handheld Infrared Light for Medical Applications
Post Your Comments:
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Italian therapeutic drug monitoring market, ...
Breaking Medicine Technology:
(Date:11/26/2015)... Viejo, CA (PRWEB) , ... November 26, 2015 ... ... users a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This ... style options. These classically-influenced trailer titles work with any font, giving users limitless ...
(Date:11/26/2015)... ... November 26, 2015 , ... Indosoft Inc., developer and distributor ... application server to improve system efficiency and reliability. , The new Q-Suite 6 platform ... standards, the system avoids locking itself into a specific piece of software for many ...
(Date:11/25/2015)... ... 2015 , ... As part of a global movement to ... together who want to combine talents and resources to help create sustainable communities ... The non-profit launched its first major fundraiser on November 6, 2015 at Bent ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in the traditional and ... of traditional and far-infrared saunas. , For traditional saunas, Finnleo is offering ... Finnish sauna wood, and Finnleo uses only European Grade A Nordic White Spruce from ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc , ... accessories. , Sauna accessories help improve the bather experience in the sauna, and ... styles for the purist looking for simplicity in design to accessories that encourage ...
Breaking Medicine News(10 mins):