Navigation Links
Vectibix(R) Significantly Improved Progression-Free Survival in Second-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer
Date:8/17/2009

THOUSAND OAKS, Calif., Aug. 17 /PRNewswire-FirstCall/ -- Amgen (Nasdaq: AMGN) today announced positive top-line results from a Phase 3 trial evaluating Vectibix((R) )(panitumumab) in combination with FOLFIRI (an irinotecan-based chemotherapy) as a second-line treatment in 1,186 patients with metastatic colorectal cancer (mCRC). The co-primary endpoints, tested independently, were progression-free and overall survival.

Vectibix significantly improved progression-free survival in combination with FOLFIRI, compared to FOLFIRI alone, in patients with KRAS wild-type mCRC. Although numerically greater, the improvement in median overall survival did not achieve statistical significance in the Vectibix arm.

The addition of Vectibix had no positive or negative effect on progression-free or overall survival in patients with tumors harboring activating KRAS mutations.

"With these data, Vectibix has now demonstrated improved progression-free survival in Phase 3 trials in patients with KRAS wild-type tumors in both first- and second-line treatment of metastatic colorectal cancer," said Roger M. Perlmutter, M.D., Ph.D. executive vice president of Research and Development at Amgen. "These results add to the growing body of evidence confirming the utility of KRAS as a predictive biomarker."

Overall, the adverse event profile was as anticipated for an anti-EGFR antibody in combination with irinotecan-based chemotherapy, including known events such as skin toxicity, diarrhea and hypomagnesemia.

Originally designed to compare the treatment effect in the overall population, the study was amended to analyze outcomes with respect to the presence or absence of activating mutations in KRAS<
'/>"/>

SOURCE Amgen
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer
2. Rigels R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial
3. Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia
4. Published Study Shows VNUS ClosureFAST(TM) System Significantly Superior to Laser for Varicose Vein Treatment
5. Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients
6. Two New Clinical Studies Show That Limited Exposure to Blood Transfusion Significantly Increases Morbidity and Mortality After Surgery
7. Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival
8. Horizon Therapeutics HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain
9. New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure
10. Arcion Therapeutics Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy
11. Prostate Cancer Immunotherapy Significantly Prolongs Survival in Men With Advanced Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... , July 25, 2014  Arena Pharmaceuticals, Inc. ... provide a corporate update and report second quarter 2014 ... on Friday, August 1, 2014. That same day, Arena ... a.m. Eastern Time (5:30 a.m. Pacific Time). ... 877.643.7155 for domestic callers and 914.495.8552 for international callers. ...
(Date:7/24/2014)... Kan. , July 24, 2014  Parnell ... two compounds that will be added to Parnell,s ... Australian-based CIMTECH Pty Ltd, a biotechnology company. The ... 122 have shown promise in bone regeneration and ... to develop the compounds for the veterinary market ...
(Date:7/24/2014)... , Deutschland, und MARSEILLE ... -- , Weltweite ... ermöglicht QIAGEN die Entwicklung von Tests ... für Blutkrebs  Neuer Test weist ... mit Knochenmarkserkrankungen (myelodysplastischen Syndromen) einen günstigen Krankheitsverlauf ...
Breaking Medicine Technology:Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 3Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 2QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 3QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 4QIAGEN erweitert Pipeline für die personalisierte Medizin um vielversprechende genomische Biomarker zur Prognosebestimmung bei Blutkrebsbehandlungen 5
... Reportlinker.com announces that a new market research ... Levosimendan - Comprehensive patent search ... unnecessary risk with the industry benchmark in comprehensive ... regularly updated, professional patent search performed by our ...
... 20, 2011 Sagent Pharmaceuticals (Nasdaq: SGNT ) ...  The size of the offering has been increased from the ... of common stock at a price to the public of ... on The NASDAQ Global Market on April 20, 2011 under ...
Cached Medicine Technology:Reportlinker Adds Levosimendan - Comprehensive patent search 2Reportlinker Adds Levosimendan - Comprehensive patent search 3Reportlinker Adds Levosimendan - Comprehensive patent search 4Sagent Pharmaceuticals Upsizes and Prices Initial Public Offering 2
(Date:7/28/2014)... Building a sense of neighborhood and outdoor ... personal outdoor space is not possible, building a park ... exercise outside is important. That’s why Old Buckingham ... playground equipment from APCPLAY. , Old Buckingham Station is ... is an historic tourist location of one of the ...
(Date:7/28/2014)... In The Tainted Burger ... to a disadvantaged consumer base, be it ... often offensive, ethnically-slanted advertisements to bombard the ... Burger." Amazon: http://www.amazon.com/s/ref=nb_sb_noss?url=search-alias%3Daps&field-keywords=tainted%20burger .) , ... and activist who says, "So what I ...
(Date:7/27/2014)... 2014 Manufacturers of natural ingredient beauty ... to achieve a younger appearance. The Cherry News company ... help men and women explore the availabilities from U.S. ... are presented in the posted guide on the Cherry ... consumers. On drawback to some natural ingredient formulas is ...
(Date:7/27/2014)... CA (PRWEB) July 27, 2014 Ticket Down ... Tickets at The Forum in Inglewood, California on November 15th. ... and diehard fans can expect to hear songs from this amazing ... of Summer concert in Inglewood, California at The Forum will be ... starting at 10:00 a.m. today local time TicketDown.com. This popular ...
(Date:7/27/2014)... The constant expansion of companies across the globe has ... Additional factors that have increased this demand include the ... communication, learning and development, security and safety, and knowledge ... enterprise video market value has crossed $11.21 billion in ... 2018 with a compound annual growth rate (CAGR) of ...
Breaking Medicine News(10 mins):Health News:Playground Creates Outdoor Fun for Community at Old Buckingham Station at Midlothian Village (VA) with APCPLAY© 2Health News:The Tainted Burger- McDonalds's Franchise Owner's Tale by Author Michael B. Potts Says McDonald's Disproportionately Markets to Minorities--Tedx Video Supports Claim 2Health News:Natural Eye Cream Buyer's Guide Published Online at Consumer News Website 2Health News:5 Seconds of Summer Tickets at The Forum in Inglewood (Los Angeles), CA Now Available For Sale at Ticket Down 2Health News:North America Enterprise Video Market is Expected to Reach $13.00 billion in 2018 - New Report by MicroMarket Monitor 2Health News:North America Enterprise Video Market is Expected to Reach $13.00 billion in 2018 - New Report by MicroMarket Monitor 3Health News:North America Enterprise Video Market is Expected to Reach $13.00 billion in 2018 - New Report by MicroMarket Monitor 4
... to Defend His TitleNORTHRIDGE, Calif., March 3 There ... names, two decks of shuffled playing cards, or a ... minutes. Chester Santos, the 2008 USA National Memory Champion, ... when he defends his title at the USA National ...
... to Raise One Million Dollars for Charity, Makes a Request ... At 56, Linda Quirk has undergone an amazing journey ... year. She began her trek across the globe by ... gone on to run the Great Wall of China, Easter ...
... reported that aspirin inhibited the growth of H. ... the activity of virulence factors of H. pylori ... H. pylori to antimicrlbials including metronidazole, clarithromycin and ... team led by Prof. Wang from Peking University First ...
... of unknown etiology that is characterized by the presence ... the past few years, the understanding of this disease ... genetically predisposed individual, certain agents such as drugs and ... , Dr. Waleed K Al-Hamoudi from Saudi Arabia ...
... March 3 Humana (NYSE: HUM ) has,recently released ... The Stay Smart, Stay Healthy videos have ... were launched on November 5, 2008, and remained,in the Top 5 ... topics in a fun and simple format. , ...
... the DNC bolsters firm,s national government affairs practiceWASHINGTON, ... nationally recognized political figure, presidential candidate and six ... an independent consultant exclusive to the government affairs ... Governor Dean will provide guidance to clients, particularly ...
Cached Medicine News:Health News:The Making of a Memory Champion 2Health News:The Making of a Memory Champion 3Health News:56-Year-Old Grandmother Heads to Antarctica to Run Her Seventh Worldwide Marathon in Under a Year 2Health News:56-Year-Old Grandmother Heads to Antarctica to Run Her Seventh Worldwide Marathon in Under a Year 3Health News:Why does aspirin increase the susceptibility of Helicobacter pylori to antimicrobials? 2Health News:Varicella zoster infection causes severe autoimmune hepatitis 2Health News:Humana Releases Stay Smart, Stay Healthy Videos in Spanish 2Health News:Howard Dean to Join McKenna Long and Aldridge LLP 2Health News:Howard Dean to Join McKenna Long and Aldridge LLP 3
... HR from Carl Zeiss was developed for ... only does it generate needle-sharp, color-fast images ... optimally adjusted to work with the microscope ... more it also allows you to work ...
... Digital camera systems for optimum image ... new digital camera system records live ... require fast exposure times at the ... in the visible spectrum assure reliable ...
... digital FireWire camera system for high resolution ... provides images of the highest color fidelity, ... users can expect perfect images due to ... cooling and innovative readout modes. The Leica ...
Coolpix 4500 microscope package includes Coolpix 4500 digital camera, MDC-A relay lens and EH52 AC adapter....
Medicine Products: