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Varespladib Receives 2010 European Society Pediatric Research Award
Date:12/7/2010

HAYWARD, Calif., Dec. 7, 2010 /PRNewswire/ -- Anthera Pharmaceuticals, Inc. (Nasdaq: ANTH), a biopharmaceutical company developing drugs to treat serious diseases associated with inflammation, today announced that their product candidate varespladib (A-001) was awarded the 2010 European Society Pediatric Research Award at the Third Congress of the European Academy of Pediatric Societies 2010 in Copenhagen, Denmark where Dr. Daniele De Luca, MD, PhDst at the University Pope's Hospital and the Pediatric Intensive Care Unit at the Catholic University of Sacred Heart in Rome, presented their study "New Anti-inflammatory Therapy for Neonatal Acute Lung Injury: Varespladib (A-001) Inhibits Ex-Vivo Secretory Phospholipase A2."

"This is a ground breaking study that demonstrates the possibility of inhibiting the enzyme responsible for surfactant catabolism in critically ill infants and neonates," stated Dr. De Luca. "Given the results obtained with varespladib we may now start designing studies for its use as a new anti-inflammatory therapy in conditions that do not have clearly efficacious therapies. Sparing endogenous surfactant and reducing inflammation using varespladib may be really helpful given the high mortality and morbidity of such conditions."  

The aim of the study was to test varespladib efficacy in an ex-vivo model of direct endotracheal administration in various types of neonatal acute lung injury. The study found that varespladib efficaciously inhibits sPLA2 in an ex-vivo model of direct administration. This might have important anti-inflammatory effects and spare surfactant from its catabolism.

About European Academy of Pediatric Societies

The EAPS is a partnership between the European Academy of Pediatrics, the European Society for Pediatric and Neonatal Intensive Care and the European Society for Pediatric Research. The EAPS Congress combin
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SOURCE Anthera Pharmaceuticals, Inc.
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