Navigation Links
Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder
Date:6/17/2013

WASHINGTON, June 17, 2013 /PRNewswire/ -- Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA) presented additional data today at ENDO 2013, the Endocrine Society's 95th Annual Meeting, demonstrating that tasimelteon can entrain (synchronize) both melatonin and cortisol rhythms. This effect further confirms tasimelteon's potential to reset the master body clock and address the circadian desynchrony which is inherent in Non-24-Hour Disorder (Non-24).  The SET (Safety and Efficacy of Tasimelteon) and RESET (Randomized-withdrawal study of the Efficacy and Safety of Tasimelteon to treat Non-24-Hour Disorder) Phase III studies were designed to assess the safety, efficacy and maintenance effect of tasimelteon for Non-24. Currently there is no approved FDA treatment for Non-24.

The simultaneous entrainment of both melatonin and cortisol reinforces tasimelteon as a circadian regulator, resetting the master body clock in the suprachiasmatic (SCN) nucleus.  Cortisol is a key regulatory hormone which exhibits a strong circadian rhythm, usually rising in the early morning and falling in the evening. The circadian regulation of cortisol is necessary for the human body to be prepared for a wide range of daily activities and physiologic functions, including blood pressure variation, utilization of fatty acids, circulating lymphocytes and immunity.

"In addition to entrainment of melatonin, entrainment of cortisol establishes tasimelteon as a circadian regulator, addressing an unmet need for people living with Non-24, a debilitating circadian rhythm disorder," said Mihael H. Polymeropoulos M.D., Vanda's President and Chief Executive Officer. 

In the SET study, tasimelteon achieved the primary endpoints of entrainment (synchronizing) of the melatonin (aMT6s) rhythm as compared to placebo and clinical
'/>"/>

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Vanda Pharmaceuticals Reports First Quarter 2012 Results
2. Vanda Pharmaceuticals Inc. Presents Scientific Posters at Society for Research on Biological Rhythms (SRBR) Annual Meeting
3. Vanda Pharmaceuticals to Present at the Jefferies 2012 Global Healthcare Conference
4. Vanda Pharmaceuticals Announces Date of Annual Meeting of Stockholders
5. Michael Cola Joins the Board of Directors of Vanda Pharmaceuticals
6. Vanda Pharmaceuticals to Present at the JMP Securities Healthcare Conference
7. Vanda Pharmaceuticals to Announce Second Quarter 2012 Financial Results on August 2, 2012
8. Vanda Pharmaceuticals to Participate in Two September Healthcare Investor Conferences
9. Vanda Pharmaceuticals Reports Third Quarter 2012 Results
10. Vanda Pharmaceuticals to Announce Fourth Quarter 2012 Financial Results on February 12, 2013
11. Vanda Announces Positive Results in the Second Phase III Study (RESET) of Tasimelteon for the Treatment of Non-24-Hour Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... , March 3, 2015 /CNW/ - Sante Medical ... Robotic Procedure for hair transplantation. The ... that safely and effectively extracts hair for transplantation. ... permanent, virtually undetectable results, with no linear scar. ... and the ease of hair restoration surgery." says ...
(Date:3/3/2015)... , March 3, 2015  AT&T 1 and ... announced that  AT&T  is the connectivity provider for Philips ... designed to help provide peace of mind to seniors ... freedom to live active lives with the confidence that ... it. The AT&T network 2 helps power GoSafe ...
(Date:3/3/2015)... Registration is officially open for MEDTEC China South ... the Shenzhen Convention & Exhibition Center. The Shenzhen ... join the MEDTEC China family of events. MEDTEC China South, ... better serve the South China market ... important region for China,s medical device ...
Breaking Medicine Technology:No linear scar. Permanent results. 2AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 2AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 3AT&T Providing Connectivity for Philips GoSafe Mobile Medical Alert System, Empowering United States Seniors to be Connected to Emergency Care On-the-Go 4Pre-registration Open for 2015 MEDTEC China South 2Pre-registration Open for 2015 MEDTEC China South 3
... in the third quarter affected nearly six times ... according to the quarterly ExpertRECALL™ Index , ... pharmaceutical and medical device recalls increased while recalls ... hit surprising five-quarter lows. (Photo: ...
... 2011 Ellman® International, Inc., a ... including the Pelleve® Wrinkle Reduction System, introduces the ... at the American Society for Dermatologic Surgery (ASDS) ... fully flexible CO2 laser system for fractional resurfacing and ...
Cached Medicine Technology:Food, Drug, Medical Device Recalls Continue to Climb According to ExpertRECALL Quarterly Index 2Food, Drug, Medical Device Recalls Continue to Climb According to ExpertRECALL Quarterly Index 3Ellman International Introduces the New Ellumine Laser at the American Society for Dermatologic Surgery (ASDS) 2011 Annual Meeting 2
(Date:3/3/2015)... Daylight Savings Time may lead to your kids ... for parents. , Parents and their children may feel a ... they set their clocks forward one hour for Daylight Savings ... one hour earlier -- you will have already lost one ... about “sleep hygiene” for their kids and teens this week, ...
(Date:3/3/2015)... Lincoln, RI (PRWEB) March 03, 2015 Sunday, ... Preparedness Week. No matter the time of year, every region ... severe weather. , That’s why Amica Insurance is ... and Prevention and Ready.gov to help keep you safe in ... , Keep dry: Change wet clothing frequently to prevent ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 -- vRad ( ... radiology practice, today announced that Arlene Sussman, MD, a ... host a live webinar to explore how telemedicine best ... breast imaging services for women virtually anywhere. Click ... Imaging Service Line” on March 4, 2015 at 1:00 ...
(Date:3/3/2015)... March 03, 2015 Splashtop Inc. ... announces Mirroring360 is now available for Epson® MoverioTM BT-200 ... the Moverio Apps Market , iPod, iPhone, and ... experience to the Epson Moverio smart glasses using Mirroring360, ... , The Epson smart glasses have an ...
(Date:3/3/2015)... March 03, 2015 According to ... http://www.idataresearch.com ), market saturation has made neurosurgery navigation ... the United States. Unit sales growth moderately increased ... as facilities replace older systems, and as new ... market is very much a replacement and upgrade ...
Breaking Medicine News(10 mins):Health News:Don’t Let Daylight Savings Disrupt Your Child’s Sleep 2Health News:Amica Insurance Has Tips for National Severe Weather Preparedness Week 2Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 2Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 3Health News:Latest vRad Webinar: Building World-Class Breast Imaging Services Virtually Anywhere with Telemedicine Best Practices 4Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 2Health News:Splashtop’s Mirroring360 Now Available for Epson® MoverioTM BT-200 Smart Glasses, Enabling Viewing of iOS Apps and Content on Glasses 3Health News:Neurosurgery Navigation System Market Reaches Saturation in the United States 2Health News:Neurosurgery Navigation System Market Reaches Saturation in the United States 3
... Sciences Corporation announced,today a new initiative that ... instruments used in medical practice and healthcare,2.0 ... draws upon the,cognitive and anthropologic sciences, is ... human intelligence,s reliance on,narrative for richly conveying ...
... Build Healthy Communities, VICTORVILLE, Calif., April 16 ... Victorville Earth Day Eco Tote giveaway.,On Tuesday, April ... will be handing out recyclable Eco Totes to ... Reduce, Reuse, Recycle program, Heritage Victor Valley,Medical Group ...
... have discovered sleep patterns in a type of anesthesia ... snooze. , The anesthetic used in the study, known ... tool to more thoroughly investigate ways of treating sleep ... one of the studys co-authors and an associate professor ...
... AFL ) announced today that it will ... on April 23, 2008., (Logo: http://www.newscom.com/cgi-bin/prnh/20041202/CLTH019LOGO ... release, Aflac Incorporated will,webcast a conference call scheduled ... the teleconference, Aflac Incorporated Chairman and CEO Dan ...
... middle could be making us hungrier, so we eat more, ... Dr. Yaiping Yang and his colleagues at the Lawson Health ... abdominal fat tissue can reproduce a hormone that stimulates fat ... in the way we think about and treat abdominal obesity. ...
... Management Program improves patient care while ... saving ... of its inaugural Best Practices in Consumer Empowerment and,Protection Awards ... NeuroScience, Inc. and Eli Lilly,and Company as Silver Award winners ...
Cached Medicine News:Health News:IC Sciences Investigates Application of Narrative Sciences for Medical Informatics Instruments 2Health News:IC Sciences Investigates Application of Narrative Sciences for Medical Informatics Instruments 3Health News:Aflac Incorporated To Release First Quarter Results on April 23, 2008 2Health News:Your belly fat could be making you hungrier 2Health News:Mental Health Prescription Program Named Winner in URAC's Best Practices in Consumer Empowerment and Protection Awards 2Health News:Mental Health Prescription Program Named Winner in URAC's Best Practices in Consumer Empowerment and Protection Awards 3Health News:Mental Health Prescription Program Named Winner in URAC's Best Practices in Consumer Empowerment and Protection Awards 4
Transcranial vascular DWL doppler....
... The Imexlab 3000DX bidirectional vascular ... optimum convenience for the physician concerned ... system is designed and made by ... the vascular diagnostic systems chosen by ...
Silhouette is easy to use with uncompromised biomechanics and is the most refined posterior fixation system....
... is a versatile, low profile, titanium ... Minimal instrumentation needed for implantation. Reduction ... Monosegmental and multisegmental applications. Worldwide market ... implantations. Tested in accordance with AS ...
Medicine Products: