Navigation Links
Vanda Pharmaceuticals to Evaluate Tasimelteon in Major Depression
Date:3/31/2011

sored by the National Institute of Mental Health, it was shown that two thirds of patients continued to exhibit symptoms even after a course with currently available treatments (2).  In addition to this partial response to treatment, patients often experience a number of significant side effects including sexual dysfunction, insomnia and weight gain.

If successful, tasimelteon could add significant value to the treatment armamentarium for depression.  Its novel mechanism of action as a circadian regulator could address both the mood as well as the sleep disruption in patients with MDD, and at the same time offer a mild side effect profile.

The Vanda Phase IIb/III trial will investigate the efficacy and safety of tasimelteon versus placebo in the treatment of MDD. The study is expected to include an 8-week treatment period and an optional open-label extension. Vanda plans to assess the antidepressant and circadian effects of tasimelteon, as well as further characterize the safety profile of the compound.  

Tasimelteon and the Body Clock

Tasimelteon is a circadian regulator that binds to two high-affinity melatonin receptors, Mel1a (MT1R) and Mel1b (MT2R).  These receptors are found in high density in the suprachiasmatic nucleus of the brain (SCN), which is responsible for synchronizing an individual's sleep/wake cycle.  Tasimelteon is currently being evaluated for the treatment of N24HSWD, which is a chronic circadian rhythm sleep disorder (CRSD) that occurs when an individual is unable to synchronize their internal clock to the 24-hour light/dark cycle.  Tasimelteon may also have applications in other CRSDs, including Delayed Sleep Phase Disorder, Jet Lag and Shift Worker Sleep Disorder.  

References

1. Hum Psychopharmacol. 2008 October; 23(7): 571–585

2. National Institutes of Mental Health:

SOURCE Vanda Pharmaceuticals Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Vanda Pharmaceuticals Submits Iloperidone New Drug Application
2. Vanda Pharmaceuticals Reports Third Quarter 2007 Results
3. Vanda Pharmaceuticals Receives FDA Acceptance of Iloperidone New Drug Application
4. Vanda Presents Phase III Iloperidone Efficacy Data
5. Phase III Data Show Vanda Pharmaceuticals Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia
6. Vanda Pharmaceuticals Provides Update on Iloperidone
7. Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet
8. FDA Approves Vanda Pharmaceuticals Fanapt(TM) for the Treatment of Schizophrenia
9. Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt(TM) in the U.S. and Canada for the Treatment of Schizophrenia
10. Vanda Pharmaceuticals Announces Expiration of Hart-Scott -Rodino Waiting Period for Exclusive License of Fanapt(TM)
11. Vanda Pharmaceuticals Announces U.S. Patent Allowance for a Long-Acting Injectable Formulation of Fanapt(TM) (iloperidone) in the U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... Sept. 3,  2015 About artificial ... devices, which are implanted or integrated into ... These include artificial heart, kidney, pancreas, and ... (polyurethane, polysulfone, and porous polypropylene), biologics, ceramics, ... organs. These organs are incorporated with different ...
(Date:9/3/2015)... 3, 2015 This Defibrillators are critical life ... of lives across globe. This report provides in-depth analysis ... Saudi Arabia . Stakeholders for this report include ... and regulatory bodies. The Saudi Arabia ... by products and by end users. In terms of ...
(Date:9/3/2015)... 3, 2015 Nevro Corp. (NYSE: NVRO ... innovative evidence-based solutions for the treatment of chronic pain, ... the Morgan Stanley Global Healthcare Conference on Thursday, September ... Nevro management is scheduled to present at 11:45 a.m. ... audio webcast, accessible in the "Investors" section of the ...
Breaking Medicine Technology:Global Artificial Organ Market 2015-2019 2Saudi Arabia Defibrillators Market: & Advanced Life Support Defibrillators; End Users; Industry Analysis, Size, Volume, Growth, Trends and Forecast 2014 - 2020 2
... LAGUNA HILLS, Calif., Sept. 30 Minnow Medical, Inc., ... thermoplasty for the treatment of in-stent restenosis and other ... executive Raymond W. Cohen has been named chief executive ... Cohen, 51, has more than 25 ...
... Ohio, Sept. 30 Although last year,s flu season ... illness and associated vaccine shortages, pharmacy experts at Cardinal ... for the 2010-2011 flu season. The upcoming ... federal government,s Advisory Committee on Immunization Practices (ACIP) has ...
Cached Medicine Technology:Minnow Medical Names Raymond W. Cohen as Chief Executive Officer 2Cardinal Health Helps Health Care Providers Prepare for 2010-2011 Flu Season 2Cardinal Health Helps Health Care Providers Prepare for 2010-2011 Flu Season 3Cardinal Health Helps Health Care Providers Prepare for 2010-2011 Flu Season 4
(Date:9/4/2015)... Grants Pass, OR (PRWEB) , ... September 04, ... ... Center that markets a line of personal humidifying medical devices, announced its only ... global climate, explains Bio-Logic Aqua® Research Founder Sharon Kleyne, body water evaporation is ...
(Date:9/4/2015)... ... 04, 2015 , ... The conference program for the upcoming ... 9-10, 2015 at the Diplomat Resort & Spa has been announced and is ... at the top of their field and will be presenting sessions such as ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... ... and development of its first neighborhood created specifically for adults with intellectual, developmental ... the Phoenix Metro area and feature 30 cottage or “pocket” homes. In this ...
(Date:9/4/2015)... ... 2015 , ... Steven Winter Associates, Inc., (SWA) is pleased ... for the Residential Award of Merit by the Connecticut Green Building Council (CTGBC) ... highly competitive field of submissions, the net-zero energy residence will be honored at ...
(Date:9/4/2015)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has written an open ... upcoming trip to the United States. , Yisrayl lays out what he says is the ... society is. Yisrayl also provides the meaning of his own name and describes what bible ...
Breaking Medicine News(10 mins):Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 2Health News:Bio-Logic Aqua® Research Announces Water Life Science and Body Water Evaporation as Research Focus and Mission 3Health News:Integrative Healthcare Symposium Focus On: The Microbiome Conference Program Announced 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 2Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 3Health News:Cottage Home Communities for Disabled Adults to Create First Viable Permanent Housing Option 4Health News:South Glastonbury Home Selected for Award by Connecticut Green Building Council 2Health News:Yisrayl Hawkins Writes Open Letter to Pope Francis In Light of Approaching U.S. Visit 2
... (EEG) test may hold the key to predicting ... drugs, particularly those related to psychiatric conditions. ... Clinical Neurophysiology , and now posted online, engineering ... machine learning to EEG patterns and successfully predicted ...
... ophthalmic pathologist at St. Michael,s Hospital, has won the prestigious ... of Medicine. Dr. Ycel received the $50,000 award for ... may lead to new treatments for glaucoma and eye tumours. ... has no lymphatics, the channels responsible for pumping fluid and ...
... you less upset about making errors, according to a ... journal of the Association for Psychological Science. The researchers ... while participants made mistakes on a test. Those who ... prominent response to mistakes than those who hadn,t. ...
... Arbor, Mich. A brief, motivational talk in the emergency ... peer violence or problems due to drinking, according to a ... Journal of the American Medical Association . ... work of University of Michigan Health System researchers who immersed ...
... a common blood disorder characterized by low hemoglobin levels, ... cancer. But researchers at Tel Aviv University have discovered ... hemoglobin levels can actually indicate a potential for colon ... Inbal Goldshtein, who works with Dr. Gabriel Chodick and ...
... Reporter , TUESDAY, Aug. 3 (HealthDay News) -- Foreign-born ... medical degrees abroad performed as well or better than ... analyzed records on nearly 250,000 patients hospitalized for a ... 2003-2006. The study included more than 6,100 doctors, including ...
Cached Medicine News:Health News:EEG predicts response to medication for schizophrenia 2Health News:EEG predicts response to medication for schizophrenia 3Health News:Brain study shows that thinking about God reduces distress -- but only for believers 2Health News:University of Michigan study: Pep talk to teens in the ER helped reduce violence, alcohol misuse 2Health News:University of Michigan study: Pep talk to teens in the ER helped reduce violence, alcohol misuse 3Health News:Is your hemoglobin 'trending'? 2Health News:Foreign-Trained Doctors As Good As U.S.-Trained Counterparts 2Health News:Foreign-Trained Doctors As Good As U.S.-Trained Counterparts 3
...
Wet-Field Hemostatic Eraser bipolar tip, packsize is 10/box....
Sterile cordless eraser tips, packsize is 10/box....
Titanium. Straight shafts with curved lower tip. Upper tip fits into positioning hole while lower jaw stabilizes the lens. Flat smooth handle with dull finish. Most popular size or model....
Medicine Products: