Navigation Links
Van Andel Institute Researchers Find Potential Drug Target For Aggressive Form Of Lymphoma
Date:6/22/2012

GRAND RAPIDS, Mich., June 22, 2012 /PRNewswire/ -- A discovery by Van Andel Institute  researchers has identified a potential drug target for NK/T-cell lymphoma, a type of cancer responsible for claiming the life of a close friend and fellow researcher.

A study authored by Bin Tean Teh, M.D., Ph.D., and published this week in Cancer Discovery, a journal of the American Association for Cancer Research, notes that a substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 (JAK3) gene mutations, indicating that patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor.

Lymphoma is a cancer that begins in the immune system. NK/T-cell lymphoma is an aggressive form of the disease with a poor prognosis that is rare in the United States, though prevalent throughout much of Asia. According to Teh, the only case ever recorded in Grand Rapids, Michigan was that which struck close friend and fellow Van Andel Institute researcher, Han-Mo Koo, Ph.D., in 2004. 

Teh and Koo began working together at Van Andel Institute in 1999 as a part of a group of founding principal investigators. Koo's promising work identifying genetic targets for anti-cancer drug development for melanoma and pancreatic cancer was cut short when he passed away from NK/T-cell lymphoma in 2004, at the age of 40. Before Koo died, Teh promised him that he would dedicate his efforts toward finding the genetic basis of the disease.

"The passing of my colleague, whom I was very close to, was the reason that I started studying NK/T-cell lymphoma. It has been a complicated puzzle, but I feel that we have pieced together enough that we will have an impact on a large number of patients with the disease," said Teh, director of the National Cancer Center Singapore-Van Andel Research Institute Translational Research Laboratory at the NCCS, and professor at the Duke-NUS Graduate Medical School in Singapore.

"We are currently putting together a proposal to test JAK inhibitors as a treatment for NK/T-cell lymphoma with JAK3 mutations," said Teh. "I am hopeful that we might have found a molecular target for the treatment of a least some patients with this otherwise fatal disease."   


'/>"/>
SOURCE Van Andel Institute
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Gentris Corporation Partners with the Shanghai Institutes of Preventative Medicine
2. Softway Solutions Develops Award-Winning Health App for Texas Heart Institute
3. Argus Health Systems to Showcase Customizable Product for Medical Drug Claim Compliance at AHIP Institute 2012
4. Profil Institute Partners with Florida Hospital to Establish East Coast Center for Clinical Metabolic Research
5. Elekta and The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital Sign Strategic Alliance to Further Cancer Research
6. Scripps Research Institutes Richard A. Lerner Wins Prince of Asturias Award for Scientific and Technical Research
7. The Illinois Back Institute Helps Patient Beat Debilitating Back Pain
8. The ALS Therapy Development Institute Partners with Neurotune to Investigate Potential Treatments for Motor Neuron Disease
9. The Rogosin Institute and Hebrew Home Collaborate to Provide New Dialysis Service for Residents and Patients
10. Roskamp Institute Reports Beneficial Effects of Nutritional Supplementation with Anatabine in an Animal Model of Multiple Sclerosis
11. University Hospitals Case Medical Centers Harrington Discovery Institute Launches Grant Program to Accelerate Drug Discovery and Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2016)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... second quarter ended March 26, 2016.  GAAP diluted ... and non-GAAP diluted EPS of $0.47 increased 14.6%.  ... reported basis, and 6.3% on a constant currency ... quarter, highlighted by 14.6% growth in non-GAAP EPS," ...
(Date:4/27/2016)... 27, 2016 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... the global skincare devices market was valued at US$ ... at a CAGR of 10.1% from 2015 to 2023 ... Browse the full Skincare Devices Market (Treatment Device - LED ...
(Date:4/27/2016)... , April 27, 2016 ... of the  "Global Anesthesia Disposables Market 2016-2020" ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ,The global anesthesia disposables ... CAGR of 4.03% during the period 2016-2020.  ... major threat to patients, safety. Organizations like ...
Breaking Medicine Technology:
(Date:4/29/2016)... , ... April 29, 2016 , ... ... healthcare awareness and author of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy ... May 2, 2016 and podcasted thereafter . Dr. Bernie Siegel, author of ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... surgeon reveals that infants born with severe congenital diaphragmatic hernia have better survival ... born with congenital diaphragmatic hernia (CDH)—a condition where the diaphragm fails to form ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... engineer of patented products, announces the Gyrociser, an exercise invention which aids in ... $2 billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. ...
(Date:4/29/2016)... New York, NY (PRWEB) , ... April 29, 2016 , ... New York City based ... surgery . This surgery is a very effective way to treat obstructive sleep apnea. Dr. ... , Orthognathic surgery is a procedure that involves one or both jaw bones. This ...
(Date:4/29/2016)... ... April 29, 2016 , ... Innovations with ... in an upcoming episode, airing third quarter 2016 via Discovery Channel. Dates and ... butter, Grassland Dairy Products, located in Greenwood, Wisconsin applies product research and development ...
Breaking Medicine News(10 mins):