Navigation Links
Vaccine Study in New England Journal of Medicine Wrong in Concluding Mercury Exposures are Harmless, States SafeMinds
Date:9/26/2007

"Study Findings and Limitations Require Further Investigations," Says

Dissenting Panel Member

ATLANTA, Sept. 26 /PRNewswire/ -- A Centers for Disease Control (CDC) study on the relationship between mercury (thimerosal) in vaccines and children's brain functioning draws a misleading conclusion, says one of the study's external consultants, Sallie Bernard, Executive Director of SafeMinds.

"Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years," appearing in the New England Journal of Medicine (NEJM, 9/27/07 issue), concludes that the study "does not support a causal association" between thimerosal and neuropsychological outcomes in children. The conclusion misleads the public, implying without qualification that a relationship has been disproved. In fact, "the study was unable to prove either the presence or absence of a causal relationship," noted Bernard, the panel's only consumer representative.

According to Bernard, unlike gold-standard randomized clinical trials, an observational study such as this cannot address causation. If, however, the findings confirm those of other studies, it can contribute to assessments of causality. This study confirmed associations detected in other studies, such as increased rates of motor and verbal tics and poorer language ability. Replication of previous studies was noted in the text but ignored in the Abstract and Concluding statement, which are the sections routinely read by the wider public.

The study's many limitations preclude sweeping conclusions on thimerosal's effects. The small sample size and few children in the highest and lowest exposure groups reduced the study's precision and ability to establish statistical significance. The study only obtained a 30% participation rate, well below the commonly accepted scientific standard of 70%. Early interventions which may have reduced or eliminated some deficits such as speech delays by age 7 to 10 years were not controlled. An analysis of combined prenatal and postnatal mercury exposures was lacking. Newborns weighing 5 lbs 8 ounces or less (9% of births) were excluded even though these infants may be more vulnerable to mercury's effects.

The conclusions should have referenced these and other limitations, as well as confirming thimerosal-associated impairments found in other studies, and as a result, called for further investigation. "Children in the U.S. and worldwide are still given vaccines containing mercury. Health officials should be erring on the side of caution," said Bernard. The data set will be made available to other researchers by the CDC, and Bernard hopes other scientists will apply alternative methodologies to study this important public health issue. She has asked the NEJM to publish her dissenting comments when the study appears online at http://www.nejm.org.

SafeMinds focuses on the role of mercury in neurodevelopmental disorders, including autism. This study did not address autism. A separate CDC-sponsored study investigating thimerosal and autism is underway.


'/>"/>
SOURCE SafeMinds
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC
3. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
4. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
5. Vaccine Can Prevent Cervical Cancer and Precancerous Lesions
6. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
7. Based on Up to 6 Years of Follow-Up, Biovest Announces Favorable Interim Blinded Data for Fast-Tracked Pivotal Phase 3 Clinical Trial of BiovaxID Anti-Cancer Vaccine for Non-Hodgkins Lymphoma
8. HepaLifes PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference
9. New Flu Vaccine from PepTcell Could Provide Immunity Against All Strains of Influenza Virus
10. Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur
11. New Flu Vaccine From PepTcell Could Provide Immunity Against All Strains of Influenza Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... -- This morning, Stock-Callers.com draws attention to ... at yesterday,s closing bell: Clovis Oncology Inc. (NASDAQ: ... GALE ), and ACADIA Pharmaceuticals Inc. (NASDAQ: ... to develop technologies and products that combat debilitating and ... use less and cleaner energy, and provide safer, cleaner ...
(Date:1/13/2017)... Concord Medical Services Holdings Limited ("Concord Medical" ... leading specialty hospital management solution provider and operator of ... in China , announced that it ... Trust Co., Ltd. ("ZRT"). The Company signed ... Taihe Healthcare Fund in October 2016. The total amount of ...
(Date:1/13/2017)... 2017  Biologics Prescribers Collaborative (BPC) applauds ... for issuing final guidance calling for distinguishable ... is an important win for patients and ... pharmacovigilance, patient safety and transparency. ... FDA, we remain concerned with "random" suffixes called for ...
Breaking Medicine Technology:
(Date:1/13/2017)... Davis, California (PRWEB) , ... January 13, 2017 ... ... certain carbohydrates that raise blood sugar levels. Counting carbohydrates is as easy as ... not the only nutrient that affects blood sugar levels. Despite being sugar-free, proteins ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... An inventor from Pahrump, Nev., used an ... "My urologist had me wear a Foley catheter and urine bag for a half year ... uncomfortable, so I decided that there should be a better way to do this." , ...
(Date:1/13/2017)... , ... January 13, 2017 , ... ... Sauna from the Finnleo factory in Cokato, MN, with the official send-off from ... and Maestro Osmo Vanska , Minnesota Orchestra’s Music Director, leading the official ...
(Date:1/13/2017)... ... January 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... of teaching people a way to peace, health and eternal joy. Yisrayl says he has ... peace. He adds that false accusations and persecution are nothing new in his world ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... Sharon Kleyne, ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on Voice ... seems like we began only yesterday,” said Sharon Kleyne to her listening audience, “yet ...
Breaking Medicine News(10 mins):