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VIVUS Reports Second Quarter and First Six Months 2011 Financial Results
Date:8/1/2011

s and available-for-sale securities of $121.6 million at June 30, 2011, as compared to $139.2 million at December 31, 2010. The decrease in cash, cash equivalents and available-for-sale securities of $17.6 million is primarily due to cash used in operations offset by proceeds of $1.9 million from the exercise of common stock options and ESPP purchases.

Qnexa UpdateWe have commenced the FORTRESS study, a retrospective observational study of fetal outcomes of offspring of women exposed to topiramate.  Top-line results of the FORTRESS study are expected in the fourth quarter of 2011.

In July 2011 we announced the top-line results of an additional retrospective study of medical claims data on oral clefts (OC) and major congenital malformations (MCMs) associated with topiramate exposure in utero. This study was conducted using medical claims and pharmacy prescription data from the Wolters Kluwer Pharma Solutions Source® Lx Patient Longitudinal Database.  This study identified 778 mother-infant dyads exposed to topiramate within 10 months prior to giving birth.  This study compared the incidence rate of OC and MCM in topiramate exposed dyads to two control groups, one comprised of 3,431 dyads exposed to other antiepileptic drugs (AEDs) during pregnancy and a second of 2,307 dyads with a diagnosis of epilepsy, but no exposure to topiramate during pregnancy. The results of the study found there were no statistically significant differences in OC or MCM frequency between the topiramate and control groups. The results of this study will be presented at the International Epilepsy Congress (IEC) in Rome, Italy on August 31, 2011 by Dr. Alison Pack, Associate Professor of Clinical Neurology, Department of Neurology, Columbia University Medical Center. This study was conducted to provide an early assessment of the teratogenic potential of topiramate.  The FORTRESS results, expected in the fourth quarter of 2011, along with the results fr
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