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VIA Pharmaceuticals Completes Enrollment in Phase 2 Acute Coronary Syndrome (ACS) Trial
Date:5/15/2008

n the study are treated once daily with one of three dose levels of VIA-2291 or placebo. "We are very pleased to close enrollment at 191 patients versus our target enrollment of 200 patients as a result of seeing fewer patients fall out of treatment than we initially expected when the trials were designed," said Dr. Rebecca Taub, senior vice president of research and development.

This is the second Phase 2 study of VIA-2291 to complete enrollment. In March 2008, VIA announced completion of enrollment in its Carotid Endarterectomy (CEA) trial, which is designed to provide direct evaluation of VIA-2291's effect on inflammation by analyzing plaque removed from the carotid arteries in patients treated with VIA-2291 or placebo. Enrollment in the third Phase 2 clinical trial, the FDG-PET Trial, is ongoing. Endpoints in this study include reduction in carotid plaque inflammation following dosing with VIA- 2291 as measured with state-of-the-art FDG-PET imaging technology, as well as assessment of standard biomarker measurements of inflammation.

VIA expects to report top line results from the ACS trial soon after top line CEA study results are presented in the third quarter.

About VIA-2291

VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to current standard of care therapies that treat risk factors, such as statins, antiplatelet and blood pressure medications, VIA-2291 is initially targeted to address the secondary prevention market for patients who have already suffered a major adverse cardiac event, but eventually could be beneficial to the broader 15.8 million patients in the U.S. who have coronary artery disease. VIA has exclusive worldwide rights to develop and commercialize VIA-2291. Based upon prior trials of VIA-2291 in more than 1,10
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SOURCE VIA Pharmaceuticals, Inc.
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