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VGX Animal Health DNA Vaccine for Dogs Could Reduce Tumor Growth and Increase Survival
Date:6/17/2011

it is almost exclusively over-expressed in tumor tissue compared to normal tissue in humans, i.e. 85% of the time its presence is in tumors. There is no other tumor-associated gene that is as widely expressed in cancers.

Therapeutic vaccines directed against the crucial telomerase protein TERT offer the potential to stimulate the rapid killing of tumor cells by enhancing the activity of telomerase-specific T cells. Such vaccines are being tested in human trials in leukemia and renal, prostate, lung, skin, pancreatic and breast cancer. For instance, Merck has licensed Inovio's electroporation delivery technology to deliver its DNA vaccine encoding hTERT in an ongoing Phase I clinical trial. Inovio is in preclinical development of its more optimized SynCon™ hTERT DNA vaccine candidate for treating human cancer targets. VGX Animal Health is developing its canine-specific TERT DNA vaccine product, VAH-5000D, for the treatment of dogs with cancers.

About VGX Animal HealthVGX Animal Health is developing DNA-based vaccines and therapies for companion and food animals utilizing proprietary plasmid-based DNA delivery and expression technology to optimize an animal's natural biological and immunological potential. The company is a majority-owned subsidiary of Inovio Pharmaceuticals, Inc. (NYSE Amex: INO).

About Inovio Pharmaceuticals, Inc. Inovio is developing a new generation of vaccines, called DNA vaccines, to treat and prevent cancers and infectious diseases. Its SynCon™ vaccines are designed to provide broad cross-strain protection against known as well as newly emergent strains of pathogens such as influenza. These vaccines, in combination with Inovio's proprietary electroporation delivery devices, have been shown to be safe and generate significant immune responses. Inovio clinical programs include three Phase II studies for vaccines treating cervical dysplasia/cancer, hepatitis C virus, and leukemia. Other clinical programs targ
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SOURCE Inovio Pharmaceuticals, Inc.
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