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VAP Cholesterol Test Helps Reveal Association Between Adiponectin Levels and Atherosclerosis
Date:7/21/2008

Detailed lipid profile helps clinicians identify risk in patients, including non-diabetics, despite normal LDL levels and statin therapy

BIRMINGHAM, Ala., July 21 /PRNewswire/ -- Using the VAP Cholesterol Test from Atherotech, researchers have identified a link between adiponectin and heart disease progression. The information could help physicians trying to pinpoint the most effective cholesterol and heart disease risk-lowering treatments in at-risk patients.

The association between low adiponectin levels, abnormal lipids, and increased coronary atherosclerosis was confirmed using the expanded cholesterol profiling capabilities of the VAP Test plus an adiponectin assay as part of an Intravascular Ultrasound (IVUS) substudy of the Diabetes Genome Project.

The single-center, prospective gene and biomarker banking registry was designed to collect extensive clinical and anatomic information on patients undergoing coronary angiography. For the substudy, fasting blood samples were collected from 185 patients undergoing coronary angiography and IVUS. Lipoprotein subclasses were measured by the VAP Test; adiponectin was measured using an immunoassay from R&D Systems.

Results of the study, published in the May issue of Diabetes Care, showed that low adiponectin levels are associated with small dense LDL cholesterol, increased plaque volume as measured by lipid-rich plaques, and a higher prevalence of IVUS-derived thickening of the inner-lining of blood vessels in non-diabetic patients. Seventy five percent of the patients were taking cholesterol lowering statins and had LDL cholesterol levels well below the required cut-off for study inclusion of 100mg/dL as well as normal HDL cholesterol levels and normal triglycerides.

"The VAP Test allowed us to define the relationship between adiponectin and circulating lipids," said Principal Investigator Steve Marso, M.D. "Had we not characterized the LDL subparticles we would not have fou
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SOURCE Atherotech, Inc.
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