Navigation Links
VAP Cholesterol Test Helps Reveal Association Between Adiponectin Levels and Atherosclerosis
Date:7/21/2008

Detailed lipid profile helps clinicians identify risk in patients, including non-diabetics, despite normal LDL levels and statin therapy

BIRMINGHAM, Ala., July 21 /PRNewswire/ -- Using the VAP Cholesterol Test from Atherotech, researchers have identified a link between adiponectin and heart disease progression. The information could help physicians trying to pinpoint the most effective cholesterol and heart disease risk-lowering treatments in at-risk patients.

The association between low adiponectin levels, abnormal lipids, and increased coronary atherosclerosis was confirmed using the expanded cholesterol profiling capabilities of the VAP Test plus an adiponectin assay as part of an Intravascular Ultrasound (IVUS) substudy of the Diabetes Genome Project.

The single-center, prospective gene and biomarker banking registry was designed to collect extensive clinical and anatomic information on patients undergoing coronary angiography. For the substudy, fasting blood samples were collected from 185 patients undergoing coronary angiography and IVUS. Lipoprotein subclasses were measured by the VAP Test; adiponectin was measured using an immunoassay from R&D Systems.

Results of the study, published in the May issue of Diabetes Care, showed that low adiponectin levels are associated with small dense LDL cholesterol, increased plaque volume as measured by lipid-rich plaques, and a higher prevalence of IVUS-derived thickening of the inner-lining of blood vessels in non-diabetic patients. Seventy five percent of the patients were taking cholesterol lowering statins and had LDL cholesterol levels well below the required cut-off for study inclusion of 100mg/dL as well as normal HDL cholesterol levels and normal triglycerides.

"The VAP Test allowed us to define the relationship between adiponectin and circulating lipids," said Principal Investigator Steve Marso, M.D. "Had we not characterized the LDL subparticles we would not have found the association between adiponectin and small dense LDL, as there was not one between adiponectin and total LDL. This relationship between adiponectin and small dense LDL moieties may prove to be an important link in understanding the risk for patients to develop lipid laden atheroma."

The VAP Test provides researchers and medical professionals with direct measurement of LDL, HDL and all relevant subclasses, and includes non-HDL, a highly accurate determination of apoB, and emerging risk factors (such as Lp(a), remnants, and small dense LDL.)

"This indicates that even patients whose cholesterol results appear normal or who are on therapy may still harbor a significant atherogenic burden leading to the development of vulnerable plaques and narrowed arteries," said James Ehrlich, M.D., Atherotech's chief medical officer. "For the clinician, this demonstrates the value of identifying and lowering the substantial residual risk that remains despite aggressive statin monotherapy. A key feature of the comprehensive VAP Test is the identification of the major lipid components of residual risk leading to proper individualized therapy."

VAP technology has been used in more than 100 clinical trials and will continue to play an important role in clinical practice and -- as demonstrated by the present study -- as a valuable analytical research tool. The VAP Test is available nationwide. For more information on the VAP Test for research and clinical trial applications, call 877.901.8510 or e-mail research@atherotech.com.

About Atherotech, Inc.

Atherotech is a cardio-diagnostic company focusing on direct measurement of the comprehensive lipid panel using the company's patented VAP Technology. The VAP Test directly measures the cholesterol content of all lipids, components and subclasses. It is the first cholesterol profile to comply with updated National Cholesterol Education Program ATP III recommendations calling for more accurate, direct low-density lipoprotein (LDL) measurement, which is unaffected by triglycerides. The VAP Cholesterol Test -- the new standard of care for patients at risk for cardiovascular disease -- is available through national and regional diagnostic laboratories and is reimbursed by most payers as well as Medicare. For more information, visit http://www.thevaptest.com.


'/>"/>
SOURCE Atherotech, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Researchers at Cleveland Clinic Identify Site of Dysfunction in HDL, Carrier of Good Cholesterol
2. Synvista Collaboration Demonstrates in Preclinical Studies the Mechanism for Defective Cholesterol Transport in Patients with Diabetes
3. Isis Reports New Data for Mipomersen in Routine High Cholesterol Patients and Provides Cumulative Safety Summary
4. New Study Shows LEVITRA Successfully Treats Erectile Dysfunction (ED) in Men with Dyslipidemia, Including High Cholesterol
5. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
6. People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels
7. Blueberry-Supplemented Diet Shows Promise in Lowering Cholesterol in Animal Trials
8. Fish Oil and Red Yeast Rice Studied for Lowering Blood Cholesterol
9. Progesterone Therapy and Preterm Birth: More Evidence Helps Identify Women Who Can Benefit
10. Siemens Preclinical Imaging System Helps The Methodist Hospital in Houston Further Its Research Mission
11. Tablet PC Technology Helps Doctors and Patients Focus on Chemotherapy Side Effects, According to Thomson Healthcare Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016  Marking its ... accessible breast and ovarian cancer risk test, ... analyzing 30 genes that highly impact the most ... Available today, the Color Test analyzes hereditary cancer ... stomach, and uterine cancers. The Color Test is ...
(Date:4/28/2016)... 28, 2016  The blood testing market in ... to Kalorama Information and The Freedonia Group in a ... acid testing.  The healthcare research firm said that ... blood collection stations and in improving testing at the ... report, Blood Testing Market in China ...
(Date:4/28/2016)... 28, 2016 , Net Sales of $1.90 ... over the prior year period, and an increase of 1.2% ... Diluted EPS for the first quarter were $0.52 reported, a ... adjusted, an increase of 29.9% over the prior year period ... earnings guidance for 2016 Zimmer Biomet Holdings, Inc. ...
Breaking Medicine Technology:
(Date:5/3/2016)... , ... May 03, 2016 , ... Elizabeth Murray has ... parrots to join her with one on her shoulder and one on her arm. ... parking lot because of years of mitral valve prolapse. , The valves of the ...
(Date:5/3/2016)... ... May 03, 2016 , ... Excessive panting in the ... pet anxiety. "Pet owners often think anxiety only manifests itself as trembling or ... other ways, and there’s things that be done about it,” says Dr. Jim Lowe, ...
(Date:5/3/2016)... ... 03, 2016 , ... Diagnotes, a leader in digital healthcare ... hospital system in South Carolina, to provide its secure mobile communication platform. , ... communication, drives workflow efficiencies and improves provider and patient satisfaction,” said Dr. Todd ...
(Date:5/3/2016)... ... May 03, 2016 , ... Boston Children’s Hospital today announced ... medical situations or practice tricky or rare procedures in an environment that looks and ... Center is also available to inventors and “hackers” to develop and test new devices ...
(Date:5/3/2016)... ... May 03, 2016 , ... Each year, about 800,000 ... of death across the United States and account for one death every four minutes. ... or are permanently disabled. HCR ManorCare is launching a video series called “Your Brain,” ...
Breaking Medicine News(10 mins):