Navigation Links
VAI Findings Could Aid Diagnosis and Treatment of Several Types of Kidney Cancer
Date:9/12/2008

Van Andel Institute researchers are first to associate unique DNA changes

with several types of renal cell carcinoma

GRAND RAPIDS, Mich., Sept. 12 /PRNewswire/ -- Van Andel Institute (VAI) researchers have identified unique DNA changes in each of several types of renal cell carcinoma (RCC), the most common form of kidney cancer in adults. These findings could aid in the diagnosis of these cancers since the many types of RCC are currently identified only by their appearance. Further research could identify drug targets for each type of RCC.

"There are so many subtypes of RCC, and currently they are identified by sight, which can be subjective," said VAI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., whose laboratory published the recent findings in Cancer Letters. "Now we have an objective, definitive way to identify several types of RCC, which could have diagnostic and prognostic value."

The researchers found DNA changes specific to type 1 and 2 papillary RCC, sarcomatoid RCC, and clear cell RCC with and without a mutation of the VHL gene. They also found changes specific to both low-grade and high-grade clear cell carcinoma tumors. The DNA changes have to do with the number of copies of different chromosomes found in tumor cells, which researchers found was different from normal cells and among different types of RCC.

Teh said that the DNA changes they found could also lead to potential drug targets. "Each type of RCC is believed to be caused by something different," said Teh, "so ideally, different targets and therapeutic strategies should be selected for each subtype for effective treatment."

According to the American Cancer Society, RCC is the most common type of kidney cancer. In the United States, approximately 54,000 new cases of RCC are diagnosed and 13,000 deaths attributed to the disease each year.

Established by Jay and Betty Van Andel in 1996, Van Andel Institute is an independent research organization dedicated to preserving, enhancing and expanding the frontiers of medical science, and to achieving excellence in education by probing fundamental issues of education and the learning process.


'/>"/>
SOURCE Van Andel Institute
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention
2. Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models
3. FDA Updates Label for AVANDIA(R) to Include Clinical Findings Demonstrating Sustained Glycemic Control for Up to Five Years
4. Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair
5. Study Findings Show Infection Control Intervention Helps Keep Kids in School
6. Landmark ATHENA Study Findings With Multaq(R) (dronedarone) Shows 24% Reduction In Cardiovascular Hospitalization or Death in Patients With Atrial Fibrillation
7. ISTA Pharmaceuticals Announces New Phase III Clinical Findings to Support Bepreve NDA Filing
8. ACORN Presents Findings of Collaborative Metastatic Colorectal Cancer Research
9. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
10. Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids
11. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
Breaking Medicine Technology:
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
Breaking Medicine News(10 mins):