Navigation Links
VAI Finding Could Lead to New Drugs for Anxiety, Depression
Date:10/15/2008

Researchers determine molecular structure of promising drug target using

new method

GRAND RAPIDS, Mich., Oct. 15 /PRNewswire/ -- Researchers in the Laboratory of Structural Sciences at Van Andel Institute (VAI) have determined how the hormone corticotrophin releasing factor (CRF) precisely binds to its receptor. This detailed structural information can help drug developers design new drugs for anxiety, depression, and related disorders.

"There are a few drugs in development to treat anxiety, depression, and other conditions by targeting the cellular receptor that CRF binds to, but there are no drugs currently on the market," said VAI Distinguished Scientific Investigator Eric Xu, Ph.D., who published his laboratory's findings in The Journal of Biological Chemistry. "There is a lot of interest in this receptor as a drug target, and we are the first to determine the structural details necessary to develop an ideal drug."

CRF is a hormone and neurotransmitter secreted by the hypothalamus area of the brain and is involved in stress response. CRF has been associated with anxiety, depression, and related disorders. The hormone's receptor is a protein on the surface of a cell or in its interior that binds to the hormone, which allows the hormone to activate changes in the cell.

Using a technique known as X-ray crystallography, VAI researchers determined the molecular structure of the part of the CRF receptor that sticks outside of the cell and binds to CRF and other proteins in the same family. This detailed structural information can help drug developers engineer a drug that more perfectly fits to the receptor, making the drug more potent. Researchers determined the structure of the receptor in three different scenarios -- one with nothing bound to the receptor, one with CRF bound to the receptor, and one that shows how the receptor binds to other proteins in the same family.

To determine the struc
'/>"/>

SOURCE Van Andel Institute
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Sports Legacy Institute Announces Findings of Forensic Examinations on Wrestler Chris Benoits Brain
2. Mayo Clinic Physicians Report Findings from Research on Sleep Disorders
3. New Anti-TNF Golimumab Significantly Reduced Signs and Symptoms of Ankylosing Spondylitis According to Phase 3 Study Findings
4. Grantees of the Avon Foundation Breast Cancer Prevention Research Initiative Gather in Houston to Report Interim Findings
5. Pharmacopeia Announces Additional Positive Findings from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)
6. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
7. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
8. Industry Executives Finding Value in Shift of Scientific Publications
9. Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids
10. RSV Researcher Makes Gains in Finding Treatments
11. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 2014 Dyadic International, Inc. ("Dyadic") (OTCQX: DYAI), ... are used to develop, manufacture and sell enzymes and ... industrial enzyme industries, announced today that it will report ... 30, 2014 after market close on Thursday, August 14, ... at 5:00 p.m. Eastern Time to discuss those results. ...
(Date:7/31/2014)... July 31, 2014  Sorrento Therapeutics, Inc. (NASDAQ: ... Amar Singh , Chief Business Officer and Executive Vice President. ... on July 30. "Sorrento is deeply saddened and ... Our immediate thoughts go to Amar,s family and friends," said ... Officer. Mr. Singh joined Sorrento in January ...
(Date:7/31/2014)... Xencor Inc. (NASDAQ: XNCR ... antibodies for the treatment of autoimmune diseases, asthma ... results for the second quarter ended June 30, 2014 ... "In the second quarter, we presented ... International Conference (ATS) demonstrating three novel mechanisms of ...
Breaking Medicine Technology:Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3Sorrento Announces the Unexpected Death of its Chief Business Officer 2Xencor Reports Second Quarter 2014 Financial Results 2Xencor Reports Second Quarter 2014 Financial Results 3Xencor Reports Second Quarter 2014 Financial Results 4Xencor Reports Second Quarter 2014 Financial Results 5Xencor Reports Second Quarter 2014 Financial Results 6Xencor Reports Second Quarter 2014 Financial Results 7Xencor Reports Second Quarter 2014 Financial Results 8
... 2011 The ophthalmic therapeutics company Xcovery Vision announced ... and Dr. Ken Mandell, President and COO, will be ... Ophthalmology (ARVO) Annual Meeting in Fort Lauderdale Florida, May ... Serial Entrepreneur recounts his repeated success as founder ...
... KINGSTOWN, R.I., April 25, 2011 On Wednesday, April ... Island Congressman James R. Langevin, Governor Lincoln Chafee, Lieutenant ... laboratory tour and luncheon at its headquarters at 211 ... April 28 Attorney General Peter F. Kilmartin will tour ...
Cached Medicine Technology:Xcovery Vision Founders to Speak at ARVO 2011 2Dominion Diagnostics Celebrates National Medical Laboratory Professionals Week with Rhode Island Elected Officials 2
(Date:8/2/2014)... Apervi, the provider of secure ... engineering for big data, announced today that Conflux ... first Enterprise data engineering Platforms to be certified ... founded by the creators of Spark, recently announced ... encourage new development on the distributed, in-memory cluster-computing ...
(Date:8/2/2014)... When the Black Hat conventioneers descend on ... one thing can be always counted on, plenty of FUD ... uncertainty and doubt. The run-up has already made its ... by Reuters on July 31st about how hackers could ... to successfully infect a system with malware, completely undetected, by ...
(Date:8/1/2014)... August 01, 2014 The Judicial Panel ... that testosterone replacement therapy caused strokes, heart attacks, and ... designated Judge Matthew F. Kennelly as the transferee judge ... to the Chicago-based federal court. , As one of ... of appointing committees of attorneys who will move the ...
(Date:8/1/2014)... By Barbara Bronson Gray ... People who are obese and work in manufacturing jobs may have ... suggests. In a study of 32 people -- half were ... obese had endurance times that were about 60 percent longer. ... in task performance. Being older -- 50 to ...
(Date:8/1/2014)... 01, 2014 As it continues to ... women who allegedly experienced the spread of uterine cancers ... surgeries, Bernstein Liebhard LLP notes the growing reaction to ... power morcellators marketed by its Ethicon, Inc. unit from ... York Times, some critics of the company said they ...
Breaking Medicine News(10 mins):Health News:Databricks Certifies Apervi Conflux Director TM on Spark, Supercharging the Data to Insight Journey 2Health News:Databricks Certifies Apervi Conflux Director TM on Spark, Supercharging the Data to Insight Journey 3Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 2Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 3Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 4Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 5Health News:Judge Kennelly Appoints Attorney Michelle Kranz to the Plaintiffs’ Executive Committee in the Testosterone Replacement Therapy MDL 2Health News:Obesity Might Slow You Down at Work 2Health News:Obesity Might Slow You Down at Work 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Reactions to Johnson & Johnson Power Morcellator Recall 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Reactions to Johnson & Johnson Power Morcellator Recall 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Reactions to Johnson & Johnson Power Morcellator Recall 4
... depends on not just the particular strain of a pathogen, ... its host, according to new research results. Scientists from ... Agriculture,s Agricultural Research Service (USDA ARS) published the results today ... demonstrates that the pattern of gene regulation--how a cell determines ...
... recommendations to ensure that Medicare beneficiaries have access to ... College of Physicians (ACP). The new policy paper, ... released at Internal Medicine 2012, ACP,s annual scientific meeting. ... advantages and disadvantages of proposals to reform Medicare in ...
... News) -- American children are being exposed to background ... finds. For the study, researchers surveyed over ... 8 months to 8 years old. After taking other ... race, age and family income, the researchers also found ...
... By Serena Gordon HealthDay Reporter , FRIDAY, April ... juvenile open-angle glaucoma, A.J. Esguerra said he,s tried not to let ... not the end of the world," said Esguerra, now 23 and ... activities, and I look at it as just one other thing ...
... mysterious, difficult-to-diagnose, and potentially deadly disease that was ... if treatment is started within the first month ... by researchers from the Perelman School of Medicine ... 565 cases of this recently discovered paraneoplastic condition, ...
... of more effective cancer drugs could be a step ... Medical School, of how an inbuilt ,security check, operates ... chromosomes. , Most cells in our bodies contain ... identities. The process of chromosome segregation is monitored by ...
Cached Medicine News:Health News:History is key factor in plant disease virulence 2Health News:History is key factor in plant disease virulence 3Health News:Internal medicine physician specialists release policy paper on reforming Medicaid 2Health News:Internal medicine physician specialists release policy paper on reforming Medicaid 3Health News:Internal medicine physician specialists release policy paper on reforming Medicaid 4Health News:U.S. Children Exposed to Hours of Background TV Daily 2Health News:For Some, Glaucoma Strikes at a Young Age 2Health News:Early treatment improves outcomes in rare, often undiagnosed form of encephalitis 2Health News:Warwick scientists uncover how 'checkpoint' proteins bind chromosomes 2
... high resolution diagnostic test for cholesterol components which ... test procedure is simple and can be done ... is clearly flagged. A color coded profile is ... in red and the good HDL in green. ...
... intended as a means of ... assay methods. This ready-to-use, three-level ... significant levels of ammonia and ... for the following instruments: AU ...
... This control is designed for monitoring ... convenient for routine and stat testing and ... Assay values are included for most frequently ... most major chemistry analyzers including: Aeroset, AU ...
... This control is designed to validate visual ... the dipstick into the control the same ... feature is the addition of creatinine and microalbumin. ... results for hCG for early pregnancy detection test ...
Medicine Products: