Navigation Links
VAI Finding Could Lead to New Drugs for Anxiety, Depression
Date:10/15/2008

Researchers determine molecular structure of promising drug target using

new method

GRAND RAPIDS, Mich., Oct. 15 /PRNewswire/ -- Researchers in the Laboratory of Structural Sciences at Van Andel Institute (VAI) have determined how the hormone corticotrophin releasing factor (CRF) precisely binds to its receptor. This detailed structural information can help drug developers design new drugs for anxiety, depression, and related disorders.

"There are a few drugs in development to treat anxiety, depression, and other conditions by targeting the cellular receptor that CRF binds to, but there are no drugs currently on the market," said VAI Distinguished Scientific Investigator Eric Xu, Ph.D., who published his laboratory's findings in The Journal of Biological Chemistry. "There is a lot of interest in this receptor as a drug target, and we are the first to determine the structural details necessary to develop an ideal drug."

CRF is a hormone and neurotransmitter secreted by the hypothalamus area of the brain and is involved in stress response. CRF has been associated with anxiety, depression, and related disorders. The hormone's receptor is a protein on the surface of a cell or in its interior that binds to the hormone, which allows the hormone to activate changes in the cell.

Using a technique known as X-ray crystallography, VAI researchers determined the molecular structure of the part of the CRF receptor that sticks outside of the cell and binds to CRF and other proteins in the same family. This detailed structural information can help drug developers engineer a drug that more perfectly fits to the receptor, making the drug more potent. Researchers determined the structure of the receptor in three different scenarios -- one with nothing bound to the receptor, one with CRF bound to the receptor, and one that shows how the receptor binds to other proteins in the same family.

To determine the structure, researchers had to crystallize the hormone and receptor in these different scenarios, a process similar to letting salty water evaporate to form salt crystals but much more difficult. The lab used a unique method to do this that they recently developed to determine the structure of the parathyroid hormone (PTH) receptor, used to treat osteoporosis. PTH and CRF receptors are in the same family of proteins.

"There are many therapeutically important receptors in the same family as CRF and PTH," said Xu, "and there is a good chance we may be able to apply our crystallizing method to even more members of this family going forward."

Established by Jay and Betty Van Andel in 1996, Van Andel Institute is an independent research organization dedicated to preserving, enhancing and expanding the frontiers of medical science, and to achieving excellence in education by probing fundamental issues of education and the learning process.

http://www.vai.org


'/>"/>
SOURCE Van Andel Institute
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Sports Legacy Institute Announces Findings of Forensic Examinations on Wrestler Chris Benoits Brain
2. Mayo Clinic Physicians Report Findings from Research on Sleep Disorders
3. New Anti-TNF Golimumab Significantly Reduced Signs and Symptoms of Ankylosing Spondylitis According to Phase 3 Study Findings
4. Grantees of the Avon Foundation Breast Cancer Prevention Research Initiative Gather in Houston to Report Interim Findings
5. Pharmacopeia Announces Additional Positive Findings from Phase 1 Multiple Ascending Dose Study of PS433540 (DARA)
6. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
7. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
8. Industry Executives Finding Value in Shift of Scientific Publications
9. Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids
10. RSV Researcher Makes Gains in Finding Treatments
11. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... YORKTOWN, N.Y. and EDMONTON, ... IBM ) scientists and the University of ... have published new data in Nature,s partner journal, ... learning algorithms helped predict instances of schizophrenia with ... technology predicted the severity of specific symptoms in ...
(Date:7/19/2017)... , July 19, 2017  Mako Medical Laboratories partnered ... the Military Family Assistance Fund (MFA) to bring 140 ... to visit with their families one last time before ... coordinate the travel and logistics needed for these soldiers. ... soldiers and their families. We just wish we could ...
(Date:7/13/2017)... WILLIAMSTON, Mich. , July 13, 2017  Centurion Medical Products, ... offers its DisImpactor ® fecal impaction removal device for hospice ... ... Patient pain management ... DisImpactor for Hospice can help alleviate patient pain while preventing unneeded ...
Breaking Medicine Technology:
(Date:7/26/2017)... ... July 26, 2017 , ... Isodiol International ... cannabis innovator, specializing in the development of pharmaceutical and consumer products, announces the ... to June 30, 2017. Iso International LLC recorded unaudited fiscal Q1 profits of ...
(Date:7/25/2017)... ... July 25, 2017 , ... “Now Hiring!” is a popular phrase at ... company has achieved record-breaking sales for over 30 consecutive years and now plans to ... The upcoming year offers excitement and growth at HDIS, following the company’s acquisition by ...
(Date:7/25/2017)... ... 25, 2017 , ... Therachat , a smart journaling ... providing demos of its smart journaling platform at the 125th American Psychological Association ... from August 3-6, 2017. , The APA Annual Convention is one of the ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... ... Winner for its Product Innovation in the prestigious CEO World Awards®. The coveted ... performance, new products and services, CEO case studies, corporate social responsibility, and milestones ...
(Date:7/24/2017)... ... 24, 2017 , ... SignatureCare Emergency Center is looking to award ... semester to a deserving student. Get your applications in now as the deadline ... Mariana Castillo who is a nursing student at Prairie View A&M University with a ...
Breaking Medicine News(10 mins):