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Use of PressureWire(R) Yields a More Accurate Assessment of Translesion Pressure Gradients in Peripheral Vasculature, Two New Studies Report
Date:3/28/2008

UPPSALA, Sweden, and WILMINGTON, Mass., March 28 /PRNewswire/ -- Use of a low profile PressureWire yields a more accurate assessment of translesion pressure gradients when compared to catheter-derived pressure gradient (CPG) measurements, according to a paper published in the Journal of Interventional Cardiology (2008; Vol. 20, Issue 1: 63-65).

The authors report that although CPG measurements derived from both a catheter and PressureWire correlated with anatomic stenosis, PressureWire gradient was more accurate in estimating the clinical significance of peripheral arterial lesions, thus reducing the risk of inappropriate intervention. The paper was based on a study of 20 lesions in 16 patients undergoing angiography for peripheral vascular disease.

Entitled "Physiologic Evaluation of Translesion Pressure Gradients in Peripheral Arteries: Comparison of PressureWire and Catheter-Derived Measurements," this study, conducted at the Beth Israel Deaconess Medical Center in Boston, is the first to assess this hypothesis in patients with peripheral arterial occlusive disease.

"We've long suspected that using a 4 or 5 French catheter for measuring pressure gradients would create artifact, simply due to its size relative to the lumen of the vessel," stated Lawrence Garcia, MD, principal investigator. "This study provides confirmation. In 100 percent of the lesions, the PressureWire provided a better physiologic assessment of the pressure gradient, without the interference of the obstruction due to the catheter."

"Due to its small size, just 0.014, and high-fidelity transducer, PressureWire is able to provide results that are far more accurate than those obtained from catheter based systems," said Jim Archetto, Chief Operating Officer for Radi Medical Systems AB. "The Beth Israel study findings are consistent with data from other trials utilizing PressureWire. Once again the data documents PressureWire as the most accurate diagnostic tool fo
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SOURCE Radi Medical Systems AB
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