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Upsher-Smith Research Shows Unique Pharmacokinetic Profile of USL255 Extended Release Topiramate
Date:4/26/2012

MAPLE GROVE, Minn., April 26, 2012 /PRNewswire/ -- Upsher-Smith Laboratories, Inc. (http://www.upsher-smith.com) today announced that three posters characterizing the pharmacokinetic (PK) profile of USL255, its once-daily, extended-release (ER) topiramate formulation, were presented at the 64th Annual American Academy of Neurology (AAN) Meeting.  One of the posters showed equivalent exposure between USL255 and equal doses of immediate-release (IR) topiramate at steady state, a second poster went on to confirm that switching between formulations did not affect steady-state plasma concentrations, and a third poster showed that USL255 demonstrated linear dose-proportionality.  These poster presentations include data demonstrating that USL255 administered once-daily provided an improved PK profile when compared to twice-daily IR topiramate.  

These data and other findings were presented on Thursday, April 26, at the 64th Annual American Academy of Neurology (AAN) Meeting in New Orleans, LA (http://www.aan.com).

"Fluctuations in plasma levels with certain anti-epileptic drugs have the potential for increased side effects at peak concentrations or break-through seizures at trough concentrations.  The development of a once-daily, extended-release topiramate formulation may result in increased treatment compliance with a more consistent plasma concentration," said Mark Halvorsen, Pharm.D., Senior Director, Clinical Development at Upsher-Smith.  "We are excited to share this Phase I data with the clinicians at this year's AAN Annual Meeting."

Abstracts of the poster presentations can be found online at http://www.aan.com.  Titles and authors are:

  • "Steady-State Pharmacokinetic Profiles of Extended- and Immediate-Release Topiramate"  Poster # P06.111.  Author
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SOURCE Upsher-Smith Laboratories, Inc.
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