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Upsher-Smith Presents Updated Extended-Release Topiramate Data (USL255) at AES Meeting
Date:12/5/2011

MAPLE GROVE, Minn., Dec. 5, 2011 /PRNewswire/ -- Upsher-Smith Laboratories, Inc. [http://www.upsher-smith.com] today announced the presentation of Phase 1 data showing that once-daily administration of USL255, a proprietary, extended-release (ER) formulation of the epilepsy medication topiramate, demonstrated linear dose-proportionality and, when compared to immediate-release (IR) topiramate administered twice-daily, an improved pharmacokinetic (PK) profile by demonstrating less topiramate fluctuation over 24 hours at steady state in healthy volunteers.

These data and other findings were presented Sunday, December 4th, at the American Epilepsy Society's (AES) 2011 Annual Meeting in Baltimore, MD [http://www.aesnet.org].

"Fluctuations in plasma levels of certain anti-epileptic drugs can cause concern for patients and their physicians, as fluctuating levels have the potential to contribute to increased side effects or break-through seizures.  A once-daily, extended-release topiramate formulation that could reduce fluctuations in plasma topiramate levels may help address these concerns," said Wesley Mark Todd, M.D., Senior Director, Medical Affairs at Upsher-Smith. "We are excited to share new Phase I data with the clinicians at this year's AES Annual Meeting."

Abstracts of these posters can be found online at www.aesnet.org. 

  • "Extended-Release Topiramate (USL255) Exhibits Linear Dose-Proportional Pharmacokinetic Characteristics"  (Poster # 2.228)  Authors:  Mark B. Halvorsen, Lawrence J. Lambrecht, Michael J. Boulware, W. Mark Todd
  • "Steady-State Pharmacokinetics of USL255, an Extended-Release Formulation of Topiramate"  (Poster # 2.227)  Authors:  Lawrence J. Lambrecht, Tricia L. Braun, W. Mark Todd, Mark B. Halvorsen
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SOURCE Upsher-Smith Laboratories, Inc.
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