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Upsher-Smith Presents Data Supporting Favorable Tolerability And Consistent Pharmacokinetic Profile Of Once-Daily USL255 (Extended-Release Topiramate)
Date:3/20/2013

MAPLE GROVE, Minn., March 20, 2013 /PRNewswire/ -- Upsher-Smith Laboratories, Inc., (Upsher-Smith) today announced the presentation of data supporting favorable tolerability and a predictable, consistent pharmacokinetic (PK) profile of USL255 at high doses following single-dose administration to healthy subjects.  USL255, an investigational once-daily, extended-release (ER) topiramate formulation is in development for the management of epilepsy in adults.  This data was presented at the 65th Annual American Academy of Neurology (AAN) Meeting in San Diego, CA (http://www.aan.com), March 16-23, 2013.

"Epilepsy drug therapy often must be carefully titrated in order to optimize benefit while minimizing adverse effects," said James Cloyd , PharmD, Professor and Lawrence C. Weaver Endowed Chair-Orphan Drug Development, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota.  "The introduction of extended-release formulations for a number of antiepileptic drugs offers the potential for management of seizures by decreasing the number of doses patients take on a daily basis and reducing the risk of adverse effects related to peak drug concentrations."

"At Upsher-Smith, we are committed to researching new treatment options for people living with challenging central nervous system conditions like epilepsy," added William Pullman, MB BS, BMedSc, PhD, FRACP, Chief Scientific Officer, Upsher-Smith.  "The data presented at AAN from the development program for USL255 adds to the existing body of evidence supporting the further development of USL255 for the once-daily management of epilepsy."

The abstract of the poster presentation can be found online at http://www.aan.com:

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SOURCE Upsher-Smith Laboratories, Inc.
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