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Updated Survival Data from Study Comparing TTF™ (Tumor Treating Fields) Therapy to Best Standard Chemotherapy for Recurrent Glioblastoma Reported at the 16th Annual Scientific Meeting of the Society for NeuroOncology
Date:11/21/2011

ANAHEIM, Calif., Nov. 21, 2011 /PRNewswire/ -- Novocure™, a commercial stage private oncology company, announced today that Dr. Eric T. Wong, Co-Director, Brain Tumor Center, Beth Israel Deaconess Medical Center in Boston, presented follow-up results of a study focusing on overall survival in patients with recurrent glioblastoma multiforme (GBM). The long-term follow-up results from the Phase III EF-11 study compared overall survival at two and three years after initiating therapy in patients with recurrent GBM who were treated with Tumor Treating Fields™ (TTF) therapy versus best standard of care chemotherapy. The results were presented at the 16th Annual Scientific Meeting of the Society for NeuroOncology in Anaheim.

The presentation described the updated survival data two years after completing recruitment of a study comparing either continuous TTF monotherapy (20-24 hours per day, 7 days a week) or best standard of care chemotherapy based on physician choice. The primary endpoint of the Phase III study was overall survival and secondary endpoints were PFS6, radiological response rate and quality of life. The study was conducted at 28 U.S. and European-based centers.

With a median follow-up of 39 months, overall survival in the TTF group compared to the best standard of care chemotherapy group at two and three years of follow-up was 9% vs. 7% and 8% vs. 1%, respectively ( p=ns). The study also showed trends in favor of TTF compared to chemotherapy in PFS6 (21.4% vs. 15.2%, respectively, p=ns) and radiological response rates (14.0% vs. 9.6%, respectively, p=ns). Finally, patients in the TTF group had many less grade 2 or higher side effects and their quality of life was better than patients receiving chemotherapy.

"We are pleased to report that TTF therapy, a non-invasive, novel cancer treatment modality showed impressive therapeutic efficacy with promising long-term survival results in our patients, "said Dr. Wong. "W
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SOURCE Novocure
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