Navigation Links
Updated Results of Two Phase 2 Ibrutinib Studies in Patients with Mantle Cell Lymphoma or Diffuse Large B-cell Lymphoma
Date:6/16/2013

SUNNYVALE, Calif., June 16, 2013 /PRNewswire/ -- Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC) today announced the results of two separate Phase 2 studies suggesting that ibrutinib, an investigational oral Bruton's tyrosine kinase (BTK) inhibitor, showed efficacy when used as a monotherapy in patients with relapsed/refractory mantle cell lymphoma (MCL) or diffuse large B-cell lymphoma (DLBCL). Pharmacyclics sponsored both studies and is jointly developing ibrutinib with Janssen Research & Development, LLC. The data were presented today at the European Hematology Association (EHA) 18th Annual Congress in Stockholm, Sweden.

The findings presented at EHA for patients with MCL or DLBCL expand on the results reported by investigators last year at the American Society of Hematology Congress in December 2012. Ibrutinib was shown to achieve the following key results among patients with relapsed/refractory MCL:

  • An overall response rate (ORR) of 68%, including a complete response (CR) of 21% where all signs of cancer are gone, and a partial response (PR) of 47%.
  • The estimated median duration of response (DOR) in all responding patients was 17.5 months. The median progression-free survival (PFS) was 13.9 months, and the median overall survival (OS) has not yet been reached, but is estimated to be 58% at 18 months.
  • Treatment-emergent adverse events (AEs) reported in greater than 20% of patients included diarrhea (50%), fatigue (41%), nausea (31%), peripheral edema (28%), dyspnea (27%), constipation (25%), upper respiratory tract infection (23%), vomiting (23%) and decreased appetite (21%) and were consistent with previously reported data. Only 8 patients discontinued due to an AE.

Professor Simon Rule,
'/>"/>

SOURCE Pharmacyclics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Hill-Rom Reports Fiscal Second Quarter Adjusted Earnings Per Share In Line With Expectations; Provides Third Quarter And Updated Full-Year Financial Outlook
2. Updated HHS Mandate Continues Attack on Religious Freedom
3. Hoggan Scientific Unveils Updated ergoFET Force Gauge for Improved Force Evaluation
4. Updated: LHA Life Sciences & Medical Technologies Virtual Conference
5. Syndax Pharmaceuticals to Present Updated Overall Survival Data With Entinostat in Metastatic Breast Cancer at ASCO
6. Ongoing Clinical Trials Reveal Groundbreaking Results - Research Report on Alexion, BioMarin, Onyx, Questcor, and ImmunoGen
7. NeuroDerm Announces Presentation of ND0612 Phase 1 and Phase 2 Results at the 2013 International Congress of Parkinsons Disease and Movement Disorders
8. New PrEP Trial Results Among Injecting Drug Users Underscore That PrEP Works When Taken Consistently
9. Amgen Announces Top-Line Results Of Phase 3 Trebananib (AMG 386) TRINOVA-1 Trial In Recurrent Ovarian Cancer
10. Lakeland Industries to Report Fiscal First Quarter Financial Results and Conduct Conference Call
11. Adamas Pharmaceuticals To Report Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia In Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Dec. 15, 2014  Stephen Squires, CEO and founder ... Materials Corp (OTCQB:QTMM), will be speaking at the ... (RCQM) on December 16th, 2014. The RCQM launch continues ... in attracting top faculty and students and by inviting ... research. "We have a long association ...
(Date:12/13/2014)... , Dec. 11, 2014 Research and Markets ... addition of the "Drug Injection Devices to ... http://photos.prnewswire.com/prnh/20130307/600769 As ... an expanding list of health conditions, drug developers ... simplify the administration process and increase the efficiency ...
(Date:12/13/2014)... 2014 Research and ... of the  "Global Capnography Market 2015-2019" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,Capnography is the measurement ... gasses during the integral part of anesthesia ... about CO2 production, alveolar ventilation, and elimination ...
Breaking Medicine Technology:Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4Global Capnography Market 2015-2019: Key Vendors are Covidien, Masimo, Philips Healthcare, Smiths Medical and Welch Allyn 2Global Capnography Market 2015-2019: Key Vendors are Covidien, Masimo, Philips Healthcare, Smiths Medical and Welch Allyn 3
... 2011 The U.S. Food and Drug Administration today ... implement during 2011 to improve the most common path ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Key actions include: ... innovative, lower-risk medical devices, Clarifying when clinical data ...
... Throughout the playoffs and championship game of Professional Football, ... play at winning TemporalScanner™ Temporal Artery Thermometers. Football fans ... announced on national radio broadcasts of pro football,s divisional ... win an Exergen TemporalScanner. The "Exergen ...
Cached Medicine Technology:FDA to Improve Most Common Review Path for Medical Devices 2Exergen 'Game Time Temperature' Contest Helps Football Fans Tackle Cold and Flu Season 2Exergen 'Game Time Temperature' Contest Helps Football Fans Tackle Cold and Flu Season 3
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... As clashes between,rebels and government troops have ... International Medical Corps (IMC) continues,delivering emergency assistance to ... safety of its staff., Tens of thousands ... of,Goma. International Medical Corps staff began relocating operations ...
... hazard, British researchers say , , THURSDAY, Oct. 30 (HealthDay ... touted for years, but heavy metal contamination found in ... health benefit into a hazard, British researchers report. , ... as Parkinson,s disease and may also increase oxidative stress, ...
... Ballot Argument, SACRAMENTO, Calif., Oct. 30 The ... by more than 300 leading California,pediatricians announcing their joint ... signed the Prop 8 ballot statement, Jane Anderson,MD, in ... issue., The pediatrician statement took issue with Dr. ...
... Election Day, researchers from Harvard School of Public Health and ... New England Journal of Medicine, find that seven ... the U.S. health care system. , The article, written by ... Analysis at the Harvard School of Public Health, Drew E. ...
... of Registered Voters in,September, As Well As Other Recent ... PARK, Calif., Oct. 30 With only a few,days ... Health and the Kaiser Family Foundation, writing for the ... that seven in ten,registered voters say major changes are ...
... Sensing,Systems, Inc. (Nasdaq: ISNS ), announced today its ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050512/CGISSLOGO ), Net income for ... per fully diluted share) compared to $1.3 million ($0.34 ... Net income for the first nine,months of 2008 was ...
Cached Medicine News:Health News:International Medical Corps Continues Delivering Emergency Relief Amid Violence in Democratic Republic of Congo 2Health News:Heavy Metals Can Taint Wine 2Health News:Heavy Metals Can Taint Wine 3Health News:NO on Prop 8 Campaign Releases Statement by 300 California Pediatricians 2Health News:Pre-election surveys show deep concern about state of health care 2Health News:Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration 2Health News:Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration 3Health News:Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration 4Health News:Image Sensing Systems Announces Third Quarter Financial Results 2Health News:Image Sensing Systems Announces Third Quarter Financial Results 3Health News:Image Sensing Systems Announces Third Quarter Financial Results 4Health News:Image Sensing Systems Announces Third Quarter Financial Results 5Health News:Image Sensing Systems Announces Third Quarter Financial Results 6Health News:Image Sensing Systems Announces Third Quarter Financial Results 7Health News:Image Sensing Systems Announces Third Quarter Financial Results 8Health News:Image Sensing Systems Announces Third Quarter Financial Results 9
Sheath Introducers with guidewires....
... Stent design, utilizing an advanced ... of stainless steel stents. This ... struts, for unparalleled flexibility plus ... Coronary Stent Systemwith thin struts ...
... Guiding Catheter provides support to enhance ... under adverse conditions. It gives you ... to your destination in cardiac interventions. ... variety of clinical situations and the ...
... Xtra, and Maximum ACT introducers represent ... specialty hemostasis introducers in the world. ... hemostasis introducers for use in interventional ... angioplasty, stenting, atherectomy, temporary pacing, endomyocardial ...
Medicine Products: