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Updated Results from Phase 2 Trial Demonstrate Prolonged Hematologic Relapse-Free Survival of Micromet's Blinatumomab in Patients with Acute Lymphoblastic Leukemia
Date:6/14/2010

observed in the eight patients who received blinatumomab and then underwent a transplant. This highlights the potential for blinatumomab to provide an opportunity to arrange a transplant, and potentially to improve the outcome of the transplant by safely reducing the burden of leukemia before transplant."

"These data continue to validate our confidence in blinatumomab's potential as a promising new treatment option for patients with ALL and heighten our excitement in the pivotal trial we are on track to begin in the third quarter," said Christian Itin, Ph.D, Micromet's President and Chief Executive Officer.  

Pivotal Trial in ALL

Based on the results reported to date in ALL, Micromet plans to initiate a pivotal, non-randomized, multi-center trial intended to confirm the efficacy and safety of blinatumomab in adult patients with B precursor ALL with minimal residual disease after treatment with front-line chemotherapy. Patients will receive 15 micrograms per meter squared per day of blinatumomab for 28 days followed by two weeks off therapy over a six week treatment cycle.  The primary endpoint of the study is MRD response as assessed by PCR analysis.  The key secondary endpoint is time to hematological relapse (for non-transplanted patients).  The Company currently plans to enroll up to 130 evaluable patients at approximately 70 leading cancer centers in Europe and the U.S.

Conference Call and Webcast

Micromet management will host a conference call on Tuesday, June 15 at 8:30 AM EDT to review the data presented at EHA. To participate in the conference call, please dial 866-770-7120 (domestic) or 617-213-8065 (international) and reference the access cod
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SOURCE Micromet, Inc.
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