Navigation Links
Updated Results from Phase 2 Trial Demonstrate Prolonged Hematologic Relapse-Free Survival of Micromet's Blinatumomab in Patients with Acute Lymphoblastic Leukemia
Date:6/14/2010

ult patients with B precursor acute lymphoblastic leukemia.  Enrolled patients had sub-microscopic evidence of leukemic cells in the bone marrow following treatment with front-line chemotherapy, so called minimal residual disease (MRD). The primary endpoint of the study was MRD response. Key secondary endpoints included time to hematological relapse, time to molecular relapse and overall incidence and severity of adverse events.  Patients received 15 micrograms per meter squared per day of blinatumomab for 28 days followed by two weeks off therapy over a six week treatment cycle.  

Phase 2 Results

21 patients were treated in this study.  Of 20 evaluable patients, 80% (16 out of 20) achieved a complete MRD response. Among the 13 non-transplanted patients, there were eight patients with non-Ph+ or t(4;11) disease. For these eight patients the median time to hematological relapse has not been reached at a median follow-up of 480 days.  For a similar group of patients with MRD positive disease treated with chemotherapy by the German Multicenter Adult ALL Study Group (GMALL), a median time to hematological relapse of approximately 200 days from diagnosis has been reported(1).

Eight of the patients in the study received an allogeneic transplant after blinatumomab treatment, all of whom are alive and in remission, ranging up to 21 months.  Overall, blinatumomab was well-tolerated. The most common adverse events (any grade) were fever, decreases of immunoglobulins, and headache.  Two patients discontinued treatment due to adverse events; seizure and syncope, respectively, with both events being completely reversible.  

"Historical experience suggests that there is a high mortality rate among patients with ALL who receive a stem cell transplant," said Dr. Topp. "Notably, no deaths or relapses have been
'/>"/>

SOURCE Micromet, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Dendreon Presents Updated IMPACT Results Confirming PROVENGE Improves Overall Survival in Patients With Metastatic Castrate-Resistant Prostate Cancer
2. Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data, Including New Survival Data, on KRX-0401 (Perifosine) in the Treatment of Advanced Multiple Myeloma at the 51st Annual Meeting of the American Society of Hematology
3. Poniard Pharmaceuticals Announces Updated Positive Clinical Data from Phase 2 Trial of Picoplatin in Colorectal Cancer and New Phase 1 Cardiac Safety Trial Results
4. Newly Updated Pharmacy State Law Compendium Available
5. Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting
6. Roxane Laboratories, Inc. Updated Launch of Calcium Acetate Capsules, 667mg
7. Sunesis Pharmaceuticals Presents Updated Clinical Data From Ongoing Phase 2 Trial of Voreloxin (Formerly SNS-595) in Ovarian Cancer Patients at the 44th ASCO Annual Meeting
8. IDM Pharma Announces Updated Data From Mifamurtide (L-MTP-PE) Compassionate Access Program
9. VIA Pharmaceuticals Announces Updated DSMB Safety Results for VIA-2291 Ongoing Phase 2 Clinical Program
10. ORTHO EVRA(R) Prescribing Information Updated
11. Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... LOUIS , July 11, 2014 /PRNewswire/ ... device company, announced today the positive, cost-effective ... its innovative SPiNPerc™ procedure. The SPiNPerc endobronchial ... of a percutaneous approach to biopsy when ... Hospitals, patients and physicians experience positive financial ...
(Date:7/10/2014)... NEWS, Virginia , 11. Juli ... Hersteller von Kameras für die molekulare ... (MBI/BSGI), hat heute die CE-Zulassung für ... dem CE-Zeichen kann Dilon das Produkt ... Vertriebsbereich auf den Großteil der europäischen ...
(Date:7/10/2014)... , July 10, 2014  RESMED INC. (NYSE: ... fourth quarter and fiscal year ended June 30, 2014 results ... Exchange market close. A press release with ResMed,s results will ... company will host a webcast to discuss operating results and ... begin at 1:30 p.m. US Pacific Time and the live ...
Breaking Medicine Technology:Veran Medical Publishes Lung Cancer Patient Management Study 2Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Group, an international generic pharmaceuticals company, today announced ... Extended-Release Tablets, 2mg, 4mg, 6mg, 8mg and 12mg, ... believes this is the first generic Requip® XL ... has commenced.   Requip® XL, 2mg, 4mg, ...
... Mass. and TORONTO, May 18, 2012 Generex ... members have joined the Scientific Advisory Board (SAB) ... the company,s AE37 breast cancer vaccine.  The following ... N. Hortobagyi, MD, FACP (University of Texas MD ...
Cached Medicine Technology:Actavis Launches First Generic Equivalent of Requip® XL (Ropinirole Extended-Release Tablets) 2Generex Augments Antigen Express Scientific Advisory Board 2Generex Augments Antigen Express Scientific Advisory Board 3Generex Augments Antigen Express Scientific Advisory Board 4
(Date:7/12/2014)... 12, 2014 Floor-grade instrument ... 4.1 out of 5. This above-average score represents ... underpinning buyer negotiation power over the three years ... Son, “during the period, surging demand for healthcare ... with new product development, have placed upward pressure ...
(Date:7/12/2014)... The largest pure occupational medicine company ... announce that it will be opening its fifth Georgia ... join four Atlanta-based Nova Medical Centers’ locations. The ... Bridge Road, and will be open from 8:30 a.m. ... Nova’s treatment philosophy of rapid return-to-work and decreased treatment ...
(Date:7/11/2014)... Recently, MagicQuinceaneraDresses.com, the popular online supplier of special ... Quinceanera dresses . The company’s new items are ... without paying a large amount of money. They are ... , The company’s online shop has become a one ... outfits. In addition to exquisite Quinceanera dresses, it also ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 The American ... America’s 55 poison centers are commending Senator Bill Nelson ... Prevention Act of 2014 on July 10, 2014. Along ... Consumer Products Safety Commission (CPSC) to enact rules requiring ... consumers. , Senate co-sponsors of the bill ...
(Date:7/11/2014)... reports that tickets to the Argentina vs. Germany World ... Brazil and Netherlands are in high demand. The ... at Estadio Nacional de Brasilia Mane Garrincha Brasila, Federal District. ... 13th at Estadio Jornalista Mario Filho - Estadio do Maracana, ... are guaranteed to be authentic and are covered by Ticket ...
Breaking Medicine News(10 mins):Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:Nova Medical Centers To Open New Facility in Augusta, Georgia 2Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2
... Afghanistan and Nigeria is a polio-endemic country, according to ... the indigenous polio transmission, according to the report. // ... the virus has also been announced. ,The ... phase with the next-generation vaccines targeting the two surviving ...
... Kong from buying poultry from southern China. Chicken happens to be ... One seller at a market close to the border said Hong ... to make it easier to get them through the customs. ... of three from a village in the Shataukok border area were ...
... India for the sake of low priced cosmetic surgery. ... rhinoplasty, and breast improvements are very expensive. // Over ... every year. ,Recent figures released by ... breast enlargement topped the list of cosmetic operations performed ...
... affected as a result of snoring, according to research results ... Center // in Illinois. Most women are negatively affected by ... to divorces, according to the research. As many as 10 ... tense relationship develops between the couple when one of them ...
... on the verge of path breaking news that suggests ... // Reduced vitamin D levels in the mother ... onset of this disorder, according to the research report, ... long frozen Danish samples hold the clues that will help ...
... been raised against a Food Standards Agency advertisement, ... appropriate evidence. // An investigation was ordered following ... a salt-challenge had lowered their hypertension by consuming ... that examined the case stated that there was ...
Cached Medicine News:Health News:More People Come To India For Cosmetic Surgery 2Health News:Sunny Side Up - Vitamin-D deficiency linked to Schizophrenia 2Health News:Government Advertisement Faces Criticism For Wrong Salt Claim 2
... the most useful features is the PupilFit ... mathematical analysis of the pupil images, producing ... instantaneously. The fitted circle is shown as ... proof that the measurement ismeaningful, and not ...
Dual-sided, Interhemispheric Grid Electrode with 16 Contact Leads; Cortical Grid Electrode with 16 Contact Leads; Pediatric Grid Electrode with Flex Connector, 0.5 cm spacing...
Ad-Techs Epidural Peg Electrodes feature a silicone-insulated titanium contact. To accommodate varying skull thicknesses, the post lengths range in length from 4 to 16 mm. The connecting lead wires e...
...
Medicine Products: