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Updated Phase 2 Data With Flutemetamol Published in Annals of Neurology
Date:9/8/2010

hibits equivalent brain uptake to that of its parent molecule, 11C-Pittsburgh compound B, while also providing high test-retest replicability and potentially greater accessibility for clinical and research use," said Rik Vandenberghe, MD, PhD, Neurology Department, University Hospitals Leuven, Belgium.

"The importance of this study is underscored by the fact that it represents the first direct comparison of 11C-Pittsburgh compound B (which is also known as PiB) to a true analog of this compound," commented William E. Klunk, MD, PhD, professor of Psychiatry and Neurology at the University of Pittsburgh. The current study shows that, in addition to providing equivalent efficacy, flutemetamol actually offers greater test-retest reliability than has been reported with PiB. Flutemetamol thus appears to be a viable and practical alternative to PiB."

The study was also the subject of Dr. Bill Jagust's editorial in the same issue of the Annals of Neurology, which provides further analysis of the study.

The ongoing flutemetamol phase 3 trial program is a series of multicenter studies that include patients who consent to brain biopsy or to post-mortem assays to determine the level of association between imaging detection of amyloid and histopathology findings. A separate study is underway in patients with MCI who may progress to AD. The trials have already commenced with recruitment and imaging of patients at multiple sites in the USA and Europe.

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