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Update of Long-Term Data on Brain Cancer Patients Receiving DCVax(R)-Brain Continues to Show Striking Improvements in Delay of Disease and Survival
Date:2/17/2009

urvival of 6.9 months with existing standard of care treatment.

DCVax(R)-Brain is a groundbreaking personalized vaccine that takes a patient's own master immune cells and the biomarkers from that patient's own tumor tissue, and activates the master immune cells so they can mobilize the full immune system to recognize and kill the tumor cells. The 10-day manufacturing process produces several years of personalized vaccine for a patient, making DCVax(R)-Brain an "off-the-shelf" product for that patient throughout the treatment period. DCVax(R)-Brain is administered as a simple injection under the skin, similar to a flu shot, and is not toxic as most chemotherapies are.

DCVax(R)-Brain is now in a large Phase II clinical trial which is currently enrolling patients at 11 medical centers across the U.S. (listed at http://www.nwbio.com).

"The long-term survival of patients treated with DCVax(R)-Brain continues to be quite striking and encouraging," commented Dr. Alton L. Boynton, President and Chief Executive Officer of NWBT, "and it is especially exciting that this long-term survival is without toxicity, enabling our patients to go on with their lives in a normal fashion."

GBM, the most aggressive form of brain cancer, is estimated to have caused more than 12,000 deaths in the United States in 2007; and brain cancer is estimated to have caused over 39,000 deaths in Europe in 2002 (in each case, the last year for which estimates are available). Beyond surgery to remove the brain tumor and radiation therapy, there are only two treatments for GBM patients currently approved by the U.S. Food and Drug Administration ("FDA"): one chemotherapy drug, and one drug-infused wafer for surgical implant. Those treatments have been shown in clinical trials to typically add only 10-12 weeks of survival in GBM patients.

Since 2005, the standard
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SOURCE Northwest Biotherapeutics, Inc.
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