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Update: OncoSec Announces Positive Results From Head & Neck and Breast Cancer Trials
Date:9/26/2011

or complete mastectomy and merits further evaluation," stated Dr. Paul Goldfarb, OncoSec's Medical Director.

Preliminary:  Phase IV Head & Neck Cancer

This Phase IV registration trial carried out in Europe enrolled 92 patients (53 males and 39 females) with 66 patients followed for up to two years. Mean age at enrollment was 61.0 years (range 20 – 86 years). Seventy-six percent of tumors treated were primary cancers, and 23% were recurrent cancers, with a mean tumor volume for all cancers of 19 cm3. Treatment was found to be safe and well-tolerated with majority of adverse events being pain (77%), infection (50%), edema (48%), and dysphagia (30%). Patient survival following treatment at 8 months was 95% (87/92) and 86% (79/92) at 24 months. In addition, 83% (19/23) of patients with primary tumors treated with bleomycin and electroporation alone at 8 months were disease free. The mean time to onset of recurrence was 379 and 276 days for primary and recurrent disease, respectively. Preliminary analysis of this data demonstrates that the primary endpoint, local control of the tumor at 8 months, was achieved.

A subset of the study results from this Phase IV Recurrent and Primary Cutaneous Head & Neck Cancer Study was published by investigators from Orebro University Hospital in Orebro, Sweden in the medical journal Dermatological Surgery, August 2010, in a paper entitled, "Electroporation Therapy of Skin Cancer in the Head and Neck Area." A second subset of results from this study was more recently published by the same group of investigators in the journal Acta Oto-Laryngologica, June 2011, in a paper entitled, "Electroporation therapy for T1 and T2 oral tongue cancer."

Dr. Lennart Lofgren, principal investigator at Obrebro University Hospital and author of the above mentioned articles, said, "OMS ElectroChemotherapy™ has demonstrated promising safety and efficacy results
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SOURCE OncoSec Medical Incorporated
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