Navigation Links
Unique Partnership Lights Up a Parkinson's Disease Research Tool
Date:11/12/2013

MJFF approached Iacovitti with the idea of using a similar strategy to create a genetically engineered rat model. Why rats? The rat brain is bigger, and therefore easier to study smaller brain structures. Additionally, rats have behavioral and physiological features that are similar to humans as compared to mice, and are ideally suited to study diseases with complex physiological and behavioral symptoms. For example, researchers can mimic Parkinson's in rats by eliminating dopamine neurons selectively with a certain toxin.

To create this rat model, MJFF, Jefferson and Taconic entered into an unprecedented agreement. Though it owns the intellectual property on the hTH-GFP recombinant DNA construct, Jefferson provided this construct to MJFF for creating the hTH-GFP rat. Using this construct, Taconic generated five founder lines of the model and shipped rats to Iacovitti for characterization to determine which of these lines produced GFP in the correct location in the brain. Taconic will breed and distribute the model at the same cost to academic and industry researchers, without an upfront license fee and at a reasonable price set by MJFF.

Visualization of fluorescent dopamine-producing neurons provides data on anatomical localization, making it possible to isolate PD-vulnerable dopamine neurons from neighboring PD-resistant dopamine neurons. In addition, scientists can now identify and separate live (GFP-expressing) dopamine-producing neurons for laboratory culture studies. This was impossible using previous methods and is invaluable for understanding the function of dopamine-producing cells and how they may be affected in Parkinson's disease.

"Taconic has a long history of providing scientists with easy access to research models. Given that tradition, we are proud to work with The Michael J. Fox Foundation and Thomas Jefferson University to help speed laboratory discoveries that could lead to better treatment for Parkinson's disease," said '/>"/>

SOURCE The Michael J. Fox Foundation for Parkinson's Research; Taconic; Thomas Jefferson University
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Upsher-Smith Research Shows Unique Pharmacokinetic Profile of USL255 Extended Release Topiramate
2. Quest Diagnostics Establishes Unique Healthcare Identifier to Improve Access to Vital Patient Health Information; 80 Million Patient IDs Created to Date
3. Cardinal Health, Detroit Medical Center, Henry Ford Health System Announce Unique Collaboration To Promote Urban Renewal
4. Unique Conference Tackles Opioid Abuse Epidemic
5. Fidelitas Launches Unique Methadone Documentation and Dispensing System in Canada
6. FDA Proposes Unique Device Identification Regulations for Medical Devices
7. Novation Applauds FDAs Unique Device Identification Rule
8. Verify Brand Supports the Proposed FDA Unique Device Identification (UDI) System for Medical Devices
9. Results For Phase 2b Trial Of Unique Investigational Cell-Based Therapy In Venous Leg Ulcers Published In The Lancet
10. Sentara Healthcare, MDLIVE Forge Unique Equity Partnership in Virtual Medicine
11. MedQIA unique CAD algorithm for Quantitation of lung involvement in diffuse lung disease used as treatment efficacy end point in study to be reported at the ERS Annual Conference in Vienna, Austria: September 1-5, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... and FARMINGTON, Conn. , ... (NYSE MKT: PTN), a biopharmaceutical company developing targeted, ... with significant unmet medical need and commercial potential, ... private placement of 2,050,000 shares of its common ... shares of its common stock.  Funds under the ...
(Date:12/24/2014)... 23, 2014 Echo Therapeutics, Inc. (NASDAQ: ... focused on skin permeation, continuous glucose monitoring and ... Hollander has been appointed Chief Executive Officer ... than 20 years of experience in the medical ... recently served as Vice President, Business Development, Otsuka ...
(Date:12/24/2014)... , December 24, 2014 ... Report on Global Disposable Syringe Industry of ... its online business intelligence library. ... Disposable Syringe Industry is a professional and ... market.  For overview analysis, the report introduces ...
Breaking Medicine Technology:Palatin Completes $20 Million Equity and $10 Million Debt Financings 2Palatin Completes $20 Million Equity and $10 Million Debt Financings 3Palatin Completes $20 Million Equity and $10 Million Debt Financings 4Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5
... CHAPEL HILL, N.C., Dec. 17, 2010 The oncology ... by many organizations in the bio-pharmaceutical sector. It,s in ... are scrutinizing their strategies and tactics to support market ... successful launch, it,s critical that companies inform thought leaders, ...
... the growing cholera epidemic in Haiti, the American Red ... the Pan American Health Organization (PAHO) to purchase, ship, ... (Logo: http://photos.prnewswire.com/prnh/20090108/RedCrossLOGO ) ... in Haiti has now exceeded 100,000. Funds will provide ...
Cached Medicine Technology:Research from Best Practices, LLC Delivers Effective Market Education Tactics and Strategies for New Oncology Products 2Red Cross Supports Pan American Health Organization with $1.5 Million in Medicine and Supplies for Cholera Response 2
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
(Date:12/25/2014)... When head lice hits a home or school, ... get rid of it while keeping it from taking over ... have the solution right in their neighborhood: Lice Troopers ... provides full spectrum head lice screening and treatment services to ... Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- The risk of ... holidays, so you need to be extra cautious, an ... we see a significant increase in patients coming in ... the Suffolk County Volunteer Firefighters Burn Center of Stony ... should be full of joy, but if not careful, ...
(Date:12/25/2014)... Dennis Thompson HealthDay ... Researchers could be closing in on a "fountain of youth" ... the health of older adults, a new study suggests. ... given a drug that targets a genetic signaling pathway linked ... Novartis report. The experimental medication, a version ...
(Date:12/25/2014)... “ SmileStix ” was featured on NewsWatch ... and coolest mobile applications on the iOS, Android, and Windows ... NewsWatch, conducted the app review and shared with viewers how ... , The old saying goes, “A picture says a thousand ... can describe a single image, because each picture holds a ...
Breaking Medicine News(10 mins):Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2
... Milestone in Program to Help Local Producers Grow ... Texas, May 26 Whole Foods Market (Nasdaq: ... organic foods supermarket, announced today that its Local ... United States with $2.5 million in low-interest loans.Whole ...
... 12 times more likely to suffer serious injury, study finds ... million Americans over age 40 have some form of inner-ear ... times more likely to suffer a serious fall, a new ... are unaware of their risk, mostly because they,ve had no ...
... 26, 2009 Babies of East Asian and South Asian ... be misclassified as underweight at birth when compared to their ... Hospital physician Dr. Joel Ray. Dr. Ray and a team ... for these ethnic groups, suggest the need to consider differences ...
... A short, preoperative team briefing prior to cardiac surgery ... improves communication and reduces errors and costs, according to ... researchers believe this is the first such study to ... briefings on specific disruptions to surgery. Disruptions were categorized ...
... May 26 Americans United for Life ... President Barack Obama nominating Sonia Sotomayor to replace Justice ... the President,s talk of finding ,common ground, this appointment ... judicial philosophy undermines common ground. She is a ...
... First Women,s Center of Homestead ORLANDO, Fla., May 26 ... newest restaurant at 2531 NE 8th Street in Homestead, ... Steakhouse to open in Florida and the seventh in ... pre-opening training period, the restaurant recently hosted a Friends ...
Cached Medicine News:Health News:Whole Foods Market(R) Lends $2.5 Million to Local Growers, Producers and Food Artisans 2Health News:Whole Foods Market(R) Lends $2.5 Million to Local Growers, Producers and Food Artisans 3Health News:Inner Ear Dysfunction Puts Older Adults at Risk of Falls 2Health News:Newborns of South Asian and East Asian descent misclassified as underweight at birth: Study 2Health News:Mayo Study Finds That Team Preop Briefing Improves Communication, Reduces Errors 2Health News:Mayo Study Finds That Team Preop Briefing Improves Communication, Reduces Errors 3Health News:Mayo Study Finds That Team Preop Briefing Improves Communication, Reduces Errors 4Health News:LongHorn Steakhouse Brings the Spirit of the West to Homestead 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: