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Unilife Announces Chairman's Letter to Shareholders
Date:4/27/2011

iness so that we can drive sales of the Unifill syringe and accelerate the commercialization of other exciting products in our pipeline. As an additional benefit, this realignment of our operations will improve our cash flow by $12MM during the 2011 calendar year.

This strategic realignment is also designed to harness the maximum potential of a significant new and emerging opportunity for Unilife. Our streamlined business structure, dynamic team, automated production systems and stringent quality standards position us to progressively emerge as the preferred 'go-to' innovation partner for pharmaceutical companies seeking elegant device solutions that meet the specific needs of their therapeutic drugs and vaccines.

Traditionally, pharmaceutical and biotechnology companies have pinned their hopes on generating at least one blockbuster drug franchise out of dozens of development programs. This is like trying to hit one home run for every 30 or 40 strikes at the ball.  It is our understanding that many large pharmaceutical companies are now looking to spread their risk by directing R&D investment towards the development of a greater number of highly personalized therapeutic drugs that can be marketed into smaller patient-specific populations. This new wave of novel drugs and vaccines, such as biologics with a high molecular complexity, will typically need to be matched with equally specialized delivery devices that are custom-designed to meet the specific requirements of the drug, and its effective administration to the patient. Rather than trying to develop such customized devices in-house, pharmaceutical companies are looking to outsource these projects to industry specialists.

What these pharmaceutical and biotechnology companies desire most is an agile, efficient and highly responsive partner that can serve as a one-stop shop for device innovation. Unilife is uniquely positioned to accommodate these unmet pharmaceutical needs. We have
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1. Unilife Realigns Operations to Drive Sales and Support Commercial Production of Unifill Syringes
2. Unilife Commences Initial Production of Unifill Prefilled Syringe
3. Unilife COO Makes Open Market Purchase of Approximately $250,000 in Companys Publicly Traded Shares
4. Unilife CEO Makes Open Market Purchase of A$500,000 in Companys Publicly Traded Shares
5. Unilife on Schedule to Fill Initial Orders for Unifill Syringe
6. Unilife to Present at the 31st Annual Cowen Health Care Conference on Wednesday, March 9, 2011 in Boston
7. Unilife Corporation Announces Financial Results For Fiscal Year 2011 Second Quarter
8. Unilife Corporation to Announce Financial Results for Fiscal 2011 Second Quarter on Monday, February 14, 2011
9. Unilife Appoints Dr. Ramin Mojdeh as Chief Operating Officer
10. Unilife Receives SPP Applications Exceeding A$12.8 Million
11. Unilife Corporation Moves into New State-of-the-Art Manufacturing Facility and Global Headquarters
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