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Une mini-hormone pour contrer le fer
Date:6/14/2013

STOCKHOLM, June 14, 2013 /PRNewswire/ --

Le docteur Elizabeta Nemeth présentera lors du 18e congrès de l'Association européenne d'hématologie (EHA - European Hematology Association) à Stockholm les conclusions d'une étude menée auprès de malades souffrant de maladies liées à une surcharge en fer qui vont contribuer à l'élaboration d'un nouveau traitement potentiel.

Les surcharges ferriques provoquent généralement des lésions dans les organes pouvant aller jusqu'à la mort. Les traitements actuellement disponibles sont lourds ou associés à des effets indésirables. Les causes de surcharge en fer dans des maladies comme l'hémochromatose génétique et la thalassémie sont des carences en hepcidine, une hormone qui régule l'absorption du fer alimentaire et la mobilisation du fer stocké. Les carences en hepcidine entraînent une absorption excessive du fer alimentaire qui est stocké dans des organes vitaux. Trouver un substitut à l'hepcidine ouvre la voie à un nouveau traitement potentiel des maladies liées à la surcharge ferrique. L'hepcidine naturelle est difficile à synthétiser et ne présente pas de propriétés pharmacologiques favorables. En définissant une structure minimale de l'hepcidine qui conserve une activité hormonale, nous avons mis au point de mini-hepcidines, des analogues peptidiques de l'hormone, que nous avons optimisés pour en améliorer la biodisponibilité et réduire les coûts de production. En nous servant de souris de laboratoire présentant un déficit en hepcidine comme modèle d'une forme grave d'hémochromatose génétique, nous avons démontré que de mini-hepcidines pouvaient empêcher totale
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SOURCE European Hematology Association
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