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US Patent Granted for a New Family of Heat Shock Protein 90 (Hsp90) Inhibitors for the Treatment of Cancer and Neurodegenerative Indications
Date:5/19/2011

60;Thus, anti-angiogenic therapies are only partly effective – as they do not inhibit invasion.  Another limitation in treating gliomas is the presence of the blood-brain barrier.  Thus, for a therapeutic to be an effective treatment for glioma, it must target both angiogenesis and invasion, and must penetrate the blood-brain barrier.

Potential Therapeutic Use in HER2+ Breast Cancer with Brain Metastases:  Amplification of Her2 receptor tyrosine kinase ("Her2") appears to occur in 20%-30% of all breast cancers.  Antibody-directed therapy with trastuzumab, which targets the extracellular domain of Her2, has been efficacious to some degree.  However, resistance to trastuzumab is common and added complications of resistance include metastatic disease where approximately 60% develop resistance after a year.  An alternate therapy which also targets Her2 is needed.  Treatment with Hsp90 inhibitors appears to induce the degradation of the Her2 receptor, thereby providing an alternate means for treating Her2+ tumors.  In fact, in clinical studies, Hsp90 inhibitors have demonstrated activity – clinical partial or complete response to therapy – against Her2+ tumors.


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SOURCE NexGenix Pharmaceuticals Inc.
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