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US Patent Granted for a New Family of Heat Shock Protein 90 (Hsp90) Inhibitors for the Treatment of Cancer and Neurodegenerative Indications
Date:5/19/2011

occurring pochonin family, Pochonia chlamydospora, and to their syntheses. The invention is further related to use of these compounds as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (Hsp90).

Prior Hsp90 Inhibitors developments: The Hsp90 inhibitors, that have been subject of pre-clinical and clinical studies by a number of pharmaceutical companies over the past decade, have been primarily based on either radicicol, isolated from naturally occurring Diheterospora chlamydosporia, or geldanamycin (which is also a naturally occurring benzoquinone ansamycin antibiotics that can be isolated from Streptomyces hygroscopicus) and its derivative 17 allylamino-17-demethoxygeldanamycin

(17-AAG).

Potential Therapeutic Use of the Company's Hsp90 Inhibitors:  Cancer indications represent the initial target indication for the Company's Hsp90 Inhibitors in the United States. NexGenix has planned a Phase I, Open-Label, multi-center, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of NexGenix's lead Hsp90 Inhibitor in patients with various solid tumor cancers including enrichment cohorts with recurrent high-grade gliomas and Her2+ breast cancer.  Additional cancer indications are under pre-clinical evaluation as further possibility for clinical trials.

Potential Therapeutic Use in Glioma:  Glioma is the most common primary, malignant brain tumor, with 15,000 new cases presenting each year in the United States alone.  Prognosis is invariably poor, with few treatment options.  Current standard of care includes surgical resection, followed by radiation and/or chemotherapy.  Even with such treatment, median survival for patients with glioma multiforme is 10-15 months, with a one-year survival rate of only 29%, and a five-year survival rate of only 6%.  The very aggressive nature of gliomas is attributed to their highly angiogenic and highly invasive nature. 
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SOURCE NexGenix Pharmaceuticals Inc.
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