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US Patent Granted for a New Family of Heat Shock Protein 90 (Hsp90) Inhibitors for the Treatment of Cancer and Neurodegenerative Indications
Date:5/19/2011

this group, five lead drug candidates have been subjected to extensive in vitro and animal studies on the basis of their pharmacokinetics, pharmacodynamics and superior efficacy, safety, and the ability to cross the blood brain barrier, and one drug candidate has been selected for clinical evaluation.  The lead drug candidate profile lends itself to addressing diseases such as glioblastoma (or "glioma", commonly known as malignant brain tumor) and other cancers, as well as neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer's Disease and Parkinson's Disease. In addition, the Company is pursuing an EMEA hybrid application, a clinical stage intralesional treatment for dermal neurofibromas, the most common lesion in Neurofibromatosis Type 1, and has discovered molecules that represent an early research stage program in inhibitors of p21-activated kinase for indications including Neurofibromatosis Type 2 and Autism Spectrum Disorders.

This news release may contain forward-looking statements that reflect NexGenix's current expectations regarding future events, including development and regulatory clearance of the NexGenix's products. Forward-looking statements involve risks and uncertainties.  Actual events could differ materially from those projected herein and depend on a number of factors, including (inter alia), the success of the NexGenix's research strategies, the applicability of the discoveries made therein, the successful and timely completion of uncertainties related to the regulatory process, and the acceptance of NexGenix's Hsp90 inhibitor and other products by consumer and medical professionals.

Other Notes

Patent: "Macrocyclic Compounds Useful as Inhibitors of Kinases and Hsp90"
Patent serial number: US 11/891,652. Filed: August 10, 2007.  Inventors: Nicolas Winssinger, et. al. Patent abstract: The invention relates to novel derivatives, analogs and intermediates of the naturally
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SOURCE NexGenix Pharmaceuticals Inc.
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