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US Patent Granted for a New Family of Heat Shock Protein 90 (Hsp90) Inhibitors for the Treatment of Cancer and Neurodegenerative Indications
Date:5/19/2011

NEW YORK, May 19, 2011 /PRNewswire/ -- NexGenix Pharmaceuticals Inc., a privately-held company developing treatments for cancer, neurodegenerative diseases, and orphan neurogenetic disorders, today announced that the United States Patent and Trademark Office (USPTO) has issued a Notice of Allowance for a key patent for a platform of Hsp90 inhibitors based on derivatives of the  naturally occurring pochonin family, Pochonia chlamydospora.  The platform of fully synthetic small molecules covered by this composition of matter patent was developed in the laboratory of Dr. Nicolas Winssinger at the University of Strasbourg (UNISTRA) and is exclusively licensed to NexGenix.

The patent, entitled "Macrocyclic Compounds Useful as Inhibitors of Kinases and Hsp90", provides an exclusivity period until August 2027.  The patent specifically covers the proprietary scaffold and its composition along with a large library of compounds, including NexGenix's lead Hsp90 inhibitors aimed at cancer and neurodegenerative indications.  The pochonin scaffold represents an advancement in Hsp90 inhibition beyond several molecules developed over the last decade based on radicicol and geldanamycin derivative (17-AAG) which have been shown to exhibit highly potent anti-tumor activity in numerous pre-clinical and clinical studies.

Professor Nicolas Winssinger of UNISTRA stated, "Through a research collaboration agreement with NexGenix in 2007, we have developed a library of hundreds of molecules based on the scaffold that is covered by the patent allowed by USPTO. These molecules have been developed through an iterative process based on extensive in vitro and in vivo studies conducted by NexGenix in the selection of a lead candidate. I am looking forward to continuing these collaborative development activities."

X-ray crystallography studies have demonstrated deeper binding of NexGenix's molecules to the Hsp90 ATP binding pocket compared to other small-
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SOURCE NexGenix Pharmaceuticals Inc.
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