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US Oncology Research Investigators Participated in Studies That Will be Presented at the 2010 American Society of Hematology Annual Meeting and Exposition
Date:12/3/2010

emia" which will be presented orally. He, along with Kathryn Kolibaba, M.D., medical oncologist with Northwest Cancer Specialists - Vancouver Cancer Center and researcher Thomas Boyd, studied the drug PCI-32765 to establish the safety and optimal dose of the orally administered drug in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.

"Many hematologic malignancies are driven by activated signaling pathways that are potential targets for drug development," said Dr. Kolibaba. "The Bruton's tyrosine kinase is an enzyme downstream of the B cell receptor that is activated in many leukemias and lymphomas. PCI-32765 is an oral selective, irreversible inhibitor of the Bruton's tyrosine kinase. Physicians in the US Oncology Research Network are excited to have access to the BTK inhibitor PCI-32765 for our patients in clinical trials in their own communities."

Five other investigators affiliated with US Oncology Research were involved in a poster abstract that will be displayed at the conference on the evening of Saturday, Dec. 4.

Rapid Prospective Identification of Non-Germinal Center B Cell-Like (GCB) Diffuse Large B-Cell Lymphoma (DLBCL) Patients for Targeted Trials: Early Results From PYRAMID, A Phase 2 Randomized Study of R-CHOP +/- Bortezomib in Newly Diagnosed Non-GCB DLBCL


Kevin Doner, Ian W Flinn, Brian K Ulrich, Stephen J Noga, Naveed M Chowhan, Steven W Papish, Tallat Mahmood, James A Reeves, Goran Broketa, Nicholas J Di Bella, Gerald J Robbins, Radhakrishnan Ramchandren, Sein Aung, William Lawler, George Mulligan, John P Leonard(1)



"This is a poster describing an exciting study which is underway in US Oncology Research," said
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SOURCE US Oncology, Inc.
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