"Many hematologic malignancies are driven by activated signaling pathways that are potential targets for drug development," said Dr. Kolibaba. "The Bruton's tyrosine kinase is an enzyme downstream of the B cell receptor that is activated in many leukemias and lymphomas. PCI-32765 is an oral selective, irreversible inhibitor of the Bruton's tyrosine kinase. Physicians in the US Oncology Research Network are excited to have access to the BTK inhibitor PCI-32765 for our patients in clinical trials in their own communities."
Five other investigators affiliated with US Oncology Research were involved in a poster abstract that will be displayed at the conference on the evening of Saturday, Dec. 4.
Rapid Prospective Identification of Non-Germinal Center B Cell-Like (GCB) Diffuse Large B-Cell Lymphoma (DLBCL) Patients for Targeted Trials: Early Results From PYRAMID, A Phase 2 Randomized Study of R-CHOP +/- Bortezomib in Newly Diagnosed Non-GCB DLBCL
Kevin Doner, Ian W Flinn, Brian K Ulrich, Stephen J Noga, Naveed M Chowhan, Steven W Papish, Tallat Mahmood, James A Reeves, Goran Broketa, Nicholas J Di Bella, Gerald J Robbins, Radhakrishnan Ramchandren, Sein Aung, William Lawler, George Mulligan, John P Leonard(1)
"This is a poster describing an exciting study which is underway in US Oncology Research," said
|SOURCE US Oncology, Inc.|
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