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US Oncology Affiliated Physicians Make a Strong Showing in ASCO Proceedings
Date:6/2/2008

HOUSTON, June 2 /PRNewswire/ -- Physicians affiliated with the US Oncology Research Network are presenting the results of their clinical research at the 44th Annual Meeting of the American Society of Clinical Oncology (ASCO) held May 30 - June 3, 2008 in Chicago.

Dr. Joyce O'Shaughnessy of Texas Oncology-Baylor Charles A Sammons Cancer Center, an affiliate of US Oncology, gave an oral presentation on findings from a randomized Phase III trial that studied lapatanib (L) alone and in combination with trastuzumab (T) in patients with HER2+ metastatic breast cancer who progressed on trastuzumab. The research is the largest study of two targeted agents in HER2+ metastatic breast cancer and the first to demonstrate the synergy of lapatanib and trastuzumab in a Phase III setting.

The research found that improved clinical outcome was achieved with the combination of L+T in patients progressing on T-based therapy and without substantial change in the side-effect profile. The role of combined anti-HER2 therapy, in combination with chemotherapy, in less heavily pretreated patients with early stage disease is ongoing in the Adjuvant L and/or T Treatment Optimization (ALTTO) study.

"More complete HER2 blockade with lapatinib and trastuzumab benefits patients whose metastatic breast cancer (MBC) is progressing in spite of trastuzumab therapy," said Dr. O'Shaughnessy. "This combination is an important new therapeutic strategy for HER2+ MBC patients, one that does not contain chemotherapy. This combination also has exciting potential as treatment for early stage breast cancer, a hypothesis that is being evaluated now in the global ALTTO trial." Dr. O'Shaughnessy serves as co-chair of the US Oncology Breast Cancer Research Committee and associate director for clinical research for US Oncology.

In addition to Dr. O'Shaughnessy's presentation, physicians affiliated with US Oncology participated in 23 oral and poster presentations and published studie
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SOURCE US Oncology, Inc.
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