Date:12/2/2010

rom ZETA showed that treatment with vandetanib significantly extended progression-free survival, the primary endpoint of the study, in patients with advanced MTC. In ZETA, vandetanib demonstrated a 54% reduction in the rate of progression compared to placebo (HR=0.46, p=0.0001). The incidence of protocol-defined QTc prolongation in the vandetanib arm was 8% compared to 0% for placebo. The most common adverse events (incidence >25%) associated with vandetanib in the ZETA study included diarrhea, rash, nausea, hypertension and headache. In the randomized phase of the ZETA study, 12% of vandetanib patients discontinued due to an adverse event compared to 3% of placebo patients. The safety profile of vandetanib in this study was similar to what has been previously observed in other studies of vandetanib in medullary thyroid and non-small cell lung cancer.

About AstraZeneca

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialization of prescription medicines. As a leader in gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease medicines, AstraZeneca generated global revenues of $32.8 billion in 2009. In the United States, AstraZeneca is a $14.8 billion healthcare business.

For more information about AstraZeneca in the US or our AZ&Me™ Prescription Savings programs, please visit www.astrazeneca-us.com or call 1-800-AZandMe (292-6363).

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