Navigation Links
UPDATE: Nile Therapeutics Announces Positive Phase 1a Results of CD-NP, a Selective NPR-B Agonist in Clinical Development for the Treatment of Heart Failure
Date:10/11/2007

BERKELEY, Calif., Oct. 11 /PRNewswire-FirstCall/ -- Nile Therapeutics, Inc. (OTC Bulletin Board: NILT), today announced results from a Phase 1a clinical study of CD-NP, Nile's selective NPR-B agonist being developed for the treatment of heart failure. The results of this study will be included in the Company's presentation today at the BIO Investor Forum in San Francisco, CA.

"The development of a peptide that has natriuretic and renal effects, with relatively little effect on blood pressure, is a potentially important achievement. The results of this trial in healthy volunteers have confirmed some of the hypotheses developed during the pre-clinical studies. We were particularly interested to see a clear, dose dependent increase in cGMP, which suggests the molecule activates the NPR receptors," commented Dr. Barry Massie, Professor of Medicine, University of California, San Francisco, Chief, Cardiology Section, San Francisco VA Hospital, and member of Nile's scientific advisory board.

Study Design

The Phase 1a study was conducted to investigate the safety, tolerability, pharmacokinetics and pharmacodynamic profile of various doses of CD-NP compared to placebo over a four-hour infusion in 22 healthy volunteers. The study evaluated several pharmacodynamic variables which may translate into safety and efficacy in the heart failure population. Nile measured the effect of CD-NP on systemic blood pressure, urinary flow rate, urinary sodium excretion, serum potassium, renal function and cGMP, a secondary messenger of the target receptor and indicator of in-vivo activity.

Study Results

CD-NP was well tolerated with no serious adverse events and all subjects completed the four-hour infusion of placebo, 10, 17.5 or 25 ng/kg/min of CD-NP.

With respect to clinical and biomarker assessments, CD-NP (placebo, 10, 17.5 and 25 ng/kg/min) increased urine flow rate versus baseline (125%, 53%, 30% and 230% average change, respectively), increa
'/>"/>

SOURCE Nile Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. GTC Biotherapeutics to Webcast Corporate Presentation at the C.E. Unterberg, Towbin Emerging Growth Life Opportunities Conference
5. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
6. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
7. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
8. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
9. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
10. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
11. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... YORK , 21. Mai 2015 ... DPRX ), ein Unternehmen für ... auf die Entwicklung und Vermarktung von ... konzentriert, kündigte heute eine wissenschaftliche Posterpräsentation ... Phase-III-Zulassungsstudie des Unternehmens vorstellt, OneStep-1 und ...
(Date:5/21/2015)... CHICAGO , May 21, 2015  Heidrick & ... executive search , leadership consulting and ... life sciences expertise among global practices announcing the addition ... Chicago office. Dietlin ... has worked globally and across R&D, Medical and Commercial ...
(Date:5/21/2015)... , May 21, 2015  Today, eight ... who prescribe biologics – Alliance for Patient ... College of Rheumatology, Biologics Prescribers Collaborative, Clinical ... Endocrine Society, and North American Society for ... a letter to U.S. Food and Drug ...
Breaking Medicine Technology:Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 2Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 3Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 4Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 5Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 6Dipexium kündigt eine Präsentation auf dem 7. International Symposium on the Diabetic Foot an 7Heidrick Increases Healthcare and Life Sciences Expertise 2Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 2Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 3Physician Groups Urge FDA to Ensure Patient Safety With Greater Transparency in Biosimilar Labeling 4
... Jan. 14, 2011 New clinical research data suggests ... tools used by physicians and provide accurate identification of ... neurodegeneration linked to Alzheimer,s Disease (AD).  Flutemetamol, a GE ... phase III development, is being studied to identify the ...
... Baylor Health Care System is today announcing its intent ... in North Texas through the implementation of the electronic ... is one of thousands of hospitals and eligible professionals ... of Health and Human Services (HHS) to demonstrate its ...
Cached Medicine Technology:GE Healthcare Presents Flutemetamol Data for Detection of Amyloid Plaque Linked to Alzheimer's Disease 2GE Healthcare Presents Flutemetamol Data for Detection of Amyloid Plaque Linked to Alzheimer's Disease 3Baylor Health Care System Registers its Commitment to Achieve Meaningful Use of the Electronic Health Record 2
(Date:5/22/2015)... Wimbledon Health Partners, the leading on-site ... and NCV testing , is proud to announce ... American National athlete, to the Wimbledon Athletics division. ... level of testing and information it provides to be ... trainers, this way they can focus on the task ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Steven Winter ... Marc Zuluaga, has been selected by Consulting-Specifying Engineer (CSE) ... award winners are featured in the May/June issue of ... building industry professionals age 40 and younger who have, ... community, as well as in other areas of their ...
(Date:5/22/2015)... Calif. (PRWEB) May 22, 2015 Bryce ... opened Anaheim Fit Body Boot Camp, recently accepted his ... so quickly after the launch of his location evidences ... the Anaheim community. , Fit Body Boot Camp is ... boot camp franchise with hundreds of locations across North ...
(Date:5/22/2015)... May 22, 2015 Javon Bea ... be recognized for providing the highest quality emergency care ... health care decision-making,” said Javon R. Bea, President and ... commitment of our employee/partners to care for and respond ... Hospitals do not apply for this award, but are ...
(Date:5/21/2015)... Los Angeles, California (PRWEB) May 21, 2015 ... Angeles area at the Hilton Hotel in San Gabriel on ... heard over and over again from men and women who ... can find the right partner." , "Many singles think that ... right person. The seeker would go from one relationship to ...
Breaking Medicine News(10 mins):Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3Health News:Steven Winter Associates’ Marc Zuluaga Earns Innovative Engineering Award 2Health News:Healthy Living Brought to Anaheim— New Fitness Boot Camp Acquires 100 Clients 2Health News:Mercy Hospital and Trauma Center Receives Women’s Choice Award for Emergency Care - Mercy Health System Javon Bea 2Health News:Bestselling Author Sheds Light on Why Modern Dating is Hurting People's Chances of Finding a Lasting Relationship 2
... doesn,t prove it,s safe, critics say , , TUESDAY, April ... appears to slow the progression of atherosclerosis in diabetic ... them from new cardiac problems, according to the results ... been associated with increased risk of heart attack and ...
... reduction in Meth use, PALTO ALTO, Calif., ... its new advertising campaign, including a series of,television ... the Oscar-nominated director and producer whose works,include "Babel," ... launched,today in Montana, are designed to communicate the ...
... his April 1, 2008 show,Dr. Phil finally brought MRSA ... aureus) has been relatively unseen on,national TV. Dr. Phil ... an entire show to the problem. The program showcased ... had a son die as a result,of the deadly ...
... Ga., April 1, 2008 Immucor, Inc.,(Nasdaq: ... instrument-reagent,systems to the blood transfusion industry, today reported ... 29, 2008., Revenue for the fiscal third ... in the same period last year. Of the ...
... sixfold increase in positive portrayal of substance abuse over ... -- Rap music is glamorizing drug use, according to ... Berkeley, who found a sixfold increase in drug ... "Positive portrayals of drug use have increased over time, ...
... Fashion, Kid Sister, Emmanuel Jal & More Help Mobilize College Students ... ... mtvU ( http://www.mtvu.com/ ),MTV,s Emmy-winning college network, in partnership with ... a month of exclusive album leaks and video premieres on mtvU.com,and ...
Cached Medicine News:Health News:Avandia May Slow Atherosclerosis After Bypass Surgery 2Health News:Avandia May Slow Atherosclerosis After Bypass Surgery 3Health News:Oscar-Nominated Filmmaker Alejandro Gonzalez Inarritu Directs New Meth Project Advertising Campaign 2Health News:Oscar-Nominated Filmmaker Alejandro Gonzalez Inarritu Directs New Meth Project Advertising Campaign 3Health News:Oscar-Nominated Filmmaker Alejandro Gonzalez Inarritu Directs New Meth Project Advertising Campaign 4Health News:Daytime TV Addresses the Onslaught of MRSA Cases in U.S. 2Health News:Immucor Announces Record Fiscal Third Quarter Results 2Health News:Immucor Announces Record Fiscal Third Quarter Results 3Health News:Immucor Announces Record Fiscal Third Quarter Results 4Health News:Immucor Announces Record Fiscal Third Quarter Results 5Health News:Immucor Announces Record Fiscal Third Quarter Results 6Health News:Immucor Announces Record Fiscal Third Quarter Results 7Health News:Immucor Announces Record Fiscal Third Quarter Results 8Health News:Rap Music Glorifying Drug Use 2Health News:mtvU Unleashes Month OF Exclusive Album 'Leaks' & Music Video Premieres in Continued Fight Against Darfur Genocide 2Health News:mtvU Unleashes Month OF Exclusive Album 'Leaks' & Music Video Premieres in Continued Fight Against Darfur Genocide 3Health News:mtvU Unleashes Month OF Exclusive Album 'Leaks' & Music Video Premieres in Continued Fight Against Darfur Genocide 4Health News:mtvU Unleashes Month OF Exclusive Album 'Leaks' & Music Video Premieres in Continued Fight Against Darfur Genocide 5
... a compact Latex based reagent kit to detect ... to determine the level of RF semi-quantitatively in ... The kit includes antigen coated fine latex particles ... in plastic squeezable dropping bottles, re-usable plastic slide, ...
RFScan Latex Test Kit-100...
The Array 360 CEAL streamlines processes with computer enhancements and optimizes productivity by offering an exclusive design for aliquot samples....
ELISA kit for detection of Rheumatoid Factor....
Medicine Products: